A5101511843- Ion Transport and Channel Regulation
- PI3K/AKT/mTOR signaling in cancer
- Genetics and Neurodevelopmental Disorders
- Microtubule and mitosis dynamics
- Plant nutrient uptake and metabolism
- Birth, Development, and Health
- Air Quality and Health Impacts
- Genetic Neurodegenerative Diseases
- Cellular transport and secretion
- Copper-based nanomaterials and applications
- Climate Change and Health Impacts
- Congenital heart defects research
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Electronic and Structural Properties of Oxides
- ZnO doping and properties
- Mechanisms of cancer metastasis
- Cardiovascular Effects of Exercise
Third Affiliated Hospital of Southern Medical University
2025
Baylor College of Medicine
2018-2021
Baylor Genetics
2018-2021
Shandong University of Traditional Chinese Medicine
2021
Wuhan University
2021
Laboratoire Bordelais de Recherche en Informatique
2019
Hong Kong University of Science and Technology
2014-2017
University of Hong Kong
2014-2017
As the primary microtubule nucleator in animal cells, γ-tubulin ring complex (γTuRC) plays a crucial role organization, but little is known about how activity of γTuRC regulated. Recently, isolated was found to contain NME7, poorly characterized member NME family. Here we report that NME7 component regulates microtubule-nucleating γTuRC. contains two putative kinase domains, A and B, shows autophosphorylating activity. Whereas domain involved autophosphorylation, B inactive. interacts with...
Abstract Studies investigating the relationship between exposure to air pollutants during pregnancy and foetal growth restriction (FGR) in women who conceive by vitro fertilisation (IVF) are lacking. The objective was investigate effect of pollutant on FGR pregnant IVF. We included conceived IVF delivered healthy singleton babies Guangzhou from October 2018 September 2023. also collected data concentrations same period. analysed impact pollution FGR. After adjusting for confounders, our...
γ-Tubulin ring complexes (γTuRCs) initiate microtubule growth and mediate attachment at microtubule-organizing centers, such as centrosomes the Golgi complex. However, mechanisms that control γTuRC-mediated nucleation have remained mostly unknown. Here, we show DNA polymerase δ catalytic subunit (PolD1) binds directly to γTuRCs potently inhibits nucleation. Whereas PolD1 depletion through RNA interference does not influence centrosome-based growth, augments Conversely, overexpression...