A5013853801- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- Hippo pathway signaling and YAP/TAZ
- Prenatal Screening and Diagnostics
- Renal and related cancers
- RNA Research and Splicing
Vrije Universiteit Brussel
2020-2023
Bio-Medical Science (South Korea)
2020
Abstract STUDY QUESTION Which processes and transcription factors specify the first second lineage segregation events during human preimplantation development? SUMMARY ANSWER Differentiation into trophectoderm (TE) cells can be initiated independently of polarity; moreover, TEAD1 YAP1 co-localize in (precursor) TE primitive endoderm (PrE) cells, suggesting a role both events. WHAT IS KNOWN ALREADY We know that polarity, YAP1/GATA3 signalling phospholipase C play key initiation compacted...
ABSTRACT We know that polarity and YAP1 play a key role in trophectoderm initiation compacted human embryos, however we little about the TEAD family of transcription factors become activated by especially if they during epiblast primitive endoderm formation. Here show compaction occurs heterogeneously between 8- 16-cell stages. While 8-cell stage blastomeres are not yet polarized, polarized outer cells non-polarized inner arise embryos. specifiers TEAD1, GATA3 mostly co-localise nuclei...