A5108167418- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Cosmology and Gravitation Theories
- Computational Physics and Python Applications
- Neutrino Physics Research
- Black Holes and Theoretical Physics
- Astrophysics and Cosmic Phenomena
- Genomics and Chromatin Dynamics
- Radiation Detection and Scintillator Technologies
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Distributed and Parallel Computing Systems
- Structural Analysis of Composite Materials
- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Protein Degradation and Inhibitors
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
European School of Molecular Medicine
2025
Center for Genomic Science
2025
Italian Institute of Technology
2025
European Institute of Oncology
2019-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
The University of Adelaide
2013-2018
Ludwig-Maximilians-Universität München
2014-2018
Deutsches Elektronen-Synchrotron DESY
2018
University of Chicago
2015-2016
Fermi National Accelerator Laboratory
2015-2016
Activation of MYC and catenin beta-1 (CTNNB1, encoding β-catenin) can co-occur in liver cancer, but how these oncogenes cooperate tumorigenesis remains unclear.We generated a mouse model allowing conditional activation WNT/β-catenin signaling (through either β-catenin or loss APC - adenomatous polyposis coli) upon expression CRE recombinase the monitored their effects on hepatocyte proliferation, apoptosis, gene profiles, tumorigenesis. strongly accelerated MYC-driven carcinogenesis liver....
Abstract Replicative stress (RS) is emerging as a promising therapeutic target in oncology, yet full exploitation of its potential requires detailed understanding the mechanisms and genes involved. Here, we investigated RNA helicase Senataxin (SETX), an enzyme that resolves RNA-DNA hybrids R-loops, to address role preventing RS by oncogenic Myc. Upon Myc activation, silencing SETX led selective engagement DNA damage response (DDR) robust cytotoxicity. Pharmacological dissection upstream...
Multiple molecular features, such as activation of specific oncogenes (e.g., MYC, BCL2) or a variety gene expression signatures, have been associated with disease course in diffuse large B-cell lymphoma (DLBCL), although their relationships and implications for targeted therapy remain to be fully unraveled. We report that MYC activity is closely correlated with-and most likely driver of-gene signatures related oxidative phosphorylation (OxPhos) DLBCL, pointing OxPhos enzymes, particular...
Abstract Eukaryotic transcription factors recognize specific DNA sequence motifs, but are also endowed with generic, non-specific DNA-binding activity: how these binding modes integrated to determine select transcriptional outputs remains unresolved. We designed mutants of the MYC factor bearing substitutions in residues that contact either backbone or bases within consensus motif (E-box), and profiled their gene-regulatory activities murine cells. Our data reveal is required for engage onto...
Max is an obligate dimerization partner for the Myc transcription factors and several repressors, such as Mnt, Mxd1-4, Mga, collectively thought to antagonize function in oncogenesis. particular, part of variant Polycomb group repressive complex PRC1.6. Here, we show that ablation distinct PRC1.6 subunit Pcgf6-but not Mga-accelerates Myc-induced lymphomagenesis Eµ-myc transgenic mice. Unexpectedly, however, Pcgf6 loss shows no significant impact on transcriptional profiles, neither...
Numerous pathologies are often manifest in Magnetic Resonance Imaging (MRI) as hyperintense or bright regions compared to normal tissue. It is of particular interest develop an algorithm detect, identify and define those Regions Interest (ROI) when analyzing MRI studies, particularly for lesions Multiple Sclerosis (MS). The objective this study analyze parameters which optimize segmentation the areas interest. To establish should be considered regions, we developed a database (DB), with...
Abstract Background & Aims Activation of MYC and CTNNB1 (encoding β-catenin) can co-occur in liver cancer, but how these oncogenes cooperate tumorigenesis remains unclear. Approach Results We generated a mouse model allowing conditional activation WNT/β-catenin signaling (through either β-catenin or Apc loss) upon expression CRE recombinase the liver, monitored their effects on hepatocyte proliferation, apoptosis, gene profiles tumorigenesis. Conditional strongly accelerated MYC-driven...
Purpose: The purpose of this work was to evaluate the dosimetric characteristics three collimation systems, 5mm circular cone (Brainlab) and square fields with HDMLC (Varian) microMLC Moduleaf, Siemens) for trigeminal neuralgia treatment. Methods: A TPS Iplan v4.5 BrainLAB used do treatment plans each collimations system in a solid water phantom isocenter at 5cm depth. Single field plan including 11 arcs fix 100° gantry range made systems. EBT3 films were positioned coronal plane measured...
Purpose: The purpose of this paper is to characterize EBT3 using two types scanner, analyzing the factors influence each dosimetry system. Methods: film used in study was GAFCHROMIC EBT3, films were exposed at a dose range between 0Gy 9Gy solid water phantom, SSD=100cm, 5cm depth and perpendicularly 6MV photon beam generated by Novalis TX linear accelerator equipped with an HDMLC. A Farmer type ion chamber TN30013 (PTW) determine delivered film. digitized scanner EPSON expression 10000XL...
Purpose: To calculate the spatial response function of various radiation detectors, to evaluate dependence on field size and analyze small fields profiles corrections by deconvolution techniques. Methods: Crossline were measured a Novalis Tx 6MV beam with HDMLC. The configuration setup was SSD=100cm depth=5cm. Five studied (200×200mm2,100×100mm2, 20×20mm2, 10×10mm2and 5×5mm2) made passive detectors (EBT3 radiochromic films TLD700 thermoluminescent detectors), ionization chambers (PTW30013,...
Abstract Upon activation, lymphocytes exit quiescence and undergo substantial increases in cell size, accompanied by activation of energy-producing anabolic pathways, widespread chromatin decompaction elevated transcriptional activity. These changes depend upon prior induction the Myc transcription factor, but how controls them remains unclear. We addressed this issue primary mouse B-cells, based on conditional deletion c-myc gene, followed LPS stimulation. was rapidly induced, became...
Abstract Multiple molecular features, such as activation of specific oncogenes (e. g. MYC , BCL2 ) or a variety gene expression signatures, have been associated with disease course in diffuse large B-cell lymphoma (DLBCL). Understanding the relationships between these features and their possible exploitation toward classification therapy remains major priority field. Here, we report that activity DLBCL is closely correlated – most likely driver signatures related to Oxidative Phosphorylation...
Abstract Max is an obligate dimerization partner for the Myc transcription factors and several repressors, such as Mnt, Mxd1-4 Mga, collectively thought to antagonize function in oncogenesis. particular, part of variant Polycomb group repressive complex PRC1.6. Here, we show that ablation distinct PRC1.6 subunit Pcgf6 – but not Mga accelerates Myc-induced lymphomagenesis Eµ- myc transgenic mice. Unexpectedly, however, loss shows no significant impact on transcriptional profiles, neither...