A5075686017- Malaria Research and Control
- Lipid Membrane Structure and Behavior
- Mosquito-borne diseases and control
- Marine Sponges and Natural Products
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- Computational Drug Discovery Methods
- HIV Research and Treatment
- Venomous Animal Envenomation and Studies
- Force Microscopy Techniques and Applications
- Invertebrate Immune Response Mechanisms
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Synthetic Organic Chemistry Methods
- Advanced Glycation End Products research
- Advanced Drug Delivery Systems
- Complement system in diseases
- Research on Leishmaniasis Studies
- Antimicrobial Peptides and Activities
- Supramolecular Self-Assembly in Materials
- Marine Biology and Environmental Chemistry
- RNA and protein synthesis mechanisms
- Proteoglycans and glycosaminoglycans research
Institute for Bioengineering of Catalonia
2016-2025
Barcelona Institute for Global Health
2016-2025
Universitat de Barcelona
2016-2025
Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona
2016-2025
Barcelona Institute for Science and Technology
2019-2022
Shanghai Institute for Science of Science
2019-2020
Institute of Science and Technology
2019-2020
FC Barcelona
2019-2020
Barcelona Centre for International Affairs
2013-2015
Marine Biological Laboratory
1996-2009
One of the hallmarks Alzheimer's disease is self-aggregation amyloid beta peptide (Abeta) in extracellular fibrils. Among different forms Abeta, 42-residue fragment (Abeta1-42) readily self-associates and nucleation centers from where fibrils can quickly grow. The strong tendency Abeta1-42 to aggregate one reasons for scarcity data on its fibril formation process. We have used atomic force microscopy (AFM) visualize liquid environment fibrillogenesis synthetic hydrophilic hydrophobic...
Alzheimer's disease neuropathology is characterized by neuronal death, amyloid beta-peptide deposits and neurofibrillary tangles composed of paired helical filaments tau protein. Although crucial for our understanding the pathogenesis disease, molecular mechanisms linking remain unknown. Here, we show that beta-peptide-induced nitro-oxidative damage promotes nitrotyrosination glycolytic enzyme triosephosphate isomerase in human neuroblastoma cells. Consequently, nitro-triosephosphate was...
Abstract The antimalarial activity of heparin, against which there are no resistances known, has not been therapeutically exploited due to its potent anticoagulating activity. Here, we have explored the antiplasmodial capacity heparin-like sulfated polysaccharides from sea cucumbers Ludwigothurea grisea and Isostichopus badionotus , red alga Botryocladia occidentalis marine sponge Desmapsamma anchorata . In vitro experiments demonstrated for most compounds significant inhibition Plasmodium...
Abstract Plants produce diverse isoprenoids, which are synthesized in plastids, mitochondria, endoplasmic reticulum (ER), and the nonorganellar cytoplasm. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) catalyzes synthesis of mevalonate, a rate-limiting step cytoplasmic pathway. Several branches pathway lead to structurally functionally varied, yet essential, isoprenoids. HMGR isoforms have been identified all plants examined. Studies based on gene expression fractionation enzyme...