A5031728320- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Advanced Biosensing Techniques and Applications
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- Hedgehog Signaling Pathway Studies
- Genetics, Bioinformatics, and Biomedical Research
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
- TGF-β signaling in diseases
Università di Camerino
2011-2016
Fondazione IRCCS Istituto Nazionale dei Tumori
2013
University of Turin
2013
University of Chieti-Pescara
2013
Several transgenic mice models solidly support the hypothesis that HER2 (ERBB2) overexpression or mutation promotes tumorigenesis. Recently, a splice variant lacking exon-16 (Δ16HER2) has been detected in human breast carcinomas. This alternative protein, normal byproduct of HER2, an increased transforming potency compared to wild-type (wt) receptors. To examine ability Δ16HER2 transform mammary epithelium vivo and monitor Δ16HER2-driven tumorigenesis live mice, we generated characterized...
Intrinsic plasticity of breast carcinoma cells allows them to undergo a transient and reversible conversion into mesenchymal disseminate distant organs, where they can re-differentiate an epithelial-like status form cohesive secondary mass. The p130Cas scaffold protein is overexpressed in human ER+ HER2+ cancer it contributes progression, invasion resistance therapy. However, its role regulating aggressive remains be determined. aim this study was investigate the molecular functional...
The crucial role of HER2 in epithelial transformation and its selective overexpression on cancer tissues makes it an ideal target for immunotherapies such as passive immunotherapy with Trastuzumab. There are, however, a number concerns regarding the use monoclonal antibodies which include resistance, repeated treatments, considerable costs, side effects that make active against desirable alternative approaches. efficacy anti-HER2 DNA vaccination has been widely demonstrated transgenic...