Sophie E. Mountcastle

ORCID: 0000-0002-4759-0437
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About
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Research Areas
  • Dental Implant Techniques and Outcomes
  • Osteoarthritis Treatment and Mechanisms
  • Oral microbiology and periodontitis research
  • Bacterial biofilms and quorum sensing
  • Lower Extremity Biomechanics and Pathologies
  • Bacterial Identification and Susceptibility Testing
  • Bone Tissue Engineering Materials
  • Tendon Structure and Treatment
  • Antimicrobial agents and applications
  • Salivary Gland Disorders and Functions
  • 3D Printing in Biomedical Research
  • Cell Image Analysis Techniques
  • Additive Manufacturing and 3D Printing Technologies
  • Antimicrobial Peptides and Activities
  • Probiotics and Fermented Foods
  • Knee injuries and reconstruction techniques

University of Birmingham
2019-2023

Engineering and Physical Sciences Research Council
2019-2021

University of Brescia
2021

The Edgbaston Hospital
2020

Abstract Quantifying biofilm formation on surfaces is challenging because traditional microbiological methods, such as total colony-forming units (CFUs), often rely manual counting. These are laborious, resource intensive techniques, more susceptible to human error. Confocal laser scanning microscopy (CLSM) a high-resolution technique that allows 3D visualisation of architecture. In combination with live/dead stain, it can be used quantify viability both transparent and opaque surfaces....

10.1038/s41522-021-00214-7 article EN cc-by npj Biofilms and Microbiomes 2021-05-14

Abstract Background Despite it being known that subchondral bone affects the viscoelasticity of cartilage, there has been little research into mechanical properties osteochondral tissue as a whole system. This study aims to unearth new knowledge concerning dynamic behaviour human and how energy is transferred through cartilage-bone interface. Methods Dynamic analysis was used determine frequency-dependent (1–90 Hz) viscoelastic unit (cartilage-bone system) well isolated cartilage specimens...

10.1186/s12891-019-2959-4 article EN cc-by BMC Musculoskeletal Disorders 2019-11-30

The purpose of this study was to create a preliminary set experimentally validated Finite Element Analysis (FEA) models, in order predict the dynamic mechanical behaviour human articular cartilage (AC). Current models consider static loading with limited independent experimental validation, while for assess AC, direct comparison and validation physical testing. Three different FEA AC were constructed, which considered both linear elastic hyperelastic models; Neo-Hookean Ogden. Models using...

10.1177/09544119231180901 article EN cc-by Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine 2023-06-22

Powder bed fusion techniques enable the production of customized and complex devices that meet requirements end user target application. The medical industry relies on these additive manufacturing technologies for advantages methods offer to accurately fit patients’ needs. Besides recent improvements, process 3D printed bespoke implants still requires optimization achieve optimal properties can mimic both chemical mechanical characteristics anatomical region interest. In particular, surface...

10.25518/esaform21.2089 article EN cc-by ESAFORM 2021 2021-04-12
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