A5082409929- Conducting polymers and applications
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Bone Tissue Engineering Materials
- Immune Cell Function and Interaction
- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Cancer Cells and Metastasis
- Microfluidic and Bio-sensing Technologies
- Polymer Surface Interaction Studies
- Ultrasound and Hyperthermia Applications
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Orthopaedic implants and arthroplasty
- Ultrasound and Cavitation Phenomena
- Photoacoustic and Ultrasonic Imaging
- Polymer Science and PVC
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- biodegradable polymer synthesis and properties
- Cytomegalovirus and herpesvirus research
- Quantum Dots Synthesis And Properties
- Ultrasound Imaging and Elastography
- Planarian Biology and Electrostimulation
- Phagocytosis and Immune Regulation
Shandong Jianzhu University
2025
Hainan Medical University
2024
Zunyi Medical University
2023-2024
Diagnologix (United States)
2017-2023
University of California, San Diego
2013-2017
State Key Laboratory of Chemical Engineering
2015
East China University of Science and Technology
2015
Moores Cancer Center
2013
McGill University
2011
Hôpital Saint-François d'Assise
2004-2009
Abstract The fabrication and surface modification of a porous cell scaffold are very important in tissue engineering. Of most concern high‐density seeding, nutrient oxygen supply, affinity. In the present study, poly( L ‐lactic acid) ‐lactic‐ co ‐glycolic (70/30) scaffolds with different pore structures were fabricated. An improved method based on Archimedes' Principle for measuring porosity scaffolds, using density bottle, was developed. Anhydrous ammonia plasma treatment used to modify...
Normal and electrically stimulated PC12 cell cultures the implantation of nerve guidance channels were performed to evaluate newly developed conductive biodegradable polymer composites. Polypyrrole (PPy) doped by butane sulfonic acid showed a significantly higher number viable cells compared with PPy polystyrenesulfonate after 6-day culture. The left proliferate for 6 days, PPy-coated membranes, showing less initial adherence, recorded same proliferation rate as did noncoated membranes....
Abstract In this paper, poly( L ‐lactic acid) (PLLA) and ‐lactic‐co‐glycolic (PLGA) were synthesized, the biocompatibility of PLGA(50/50) (molar ratio) was evaluated by observing tissue response during implanting into rats. After implanted rats for 12 weeks, lymphocytes plasma cells became small or disappeared at muscle implant site which indicates is very good. A series porous cell scaffolds PLGA PLLA prepared using a solution‐casting/salt‐leaching technique. An improved method in density...
Abstract Electrically conductive biodegradable polymer membranes were prepared by mixing polypyrrole particles with poly( L ‐lactic acid) solution followed casting and solvent evaporation. Multi‐well electrical cell culture plates fabricated to host electrically stimulated monitor parameters. Human cutaneous fibroblasts cultured on or without stimulation (ES). Cell count, MTT, Hoechst staining, SEM performed characterize the cells. The supported adhesion proliferation of in both presence...
Abstract Polypyrrole (PPy) is a promising conductive polymer for tissue engineering and bioelectrical applications. However, its electrical conductivity deteriorates easily in aqueous conditions. Cell adhesion to PPy also relatively poor. The goal of this study was simultaneously improve the stability cell by using heparin (HE) as dopant, HE both polyanion an important glycosaminoglycan membranes extracellular matrix. particles doped with were synthesized through emulsion polymerization...
Abstract This study evaluated the in vivo biocompatibility and biodegradation behavior of a novel polypyrrole (PPy)/poly( D , L ‐lactide) (PDLLA) composite PPy‐coated poly( ‐lactide‐ co ‐glycolide) membranes. Test membranes were implanted subcutaneously rats for 3–120 days. The was assessed by quantifying alkaline acid phosphatase secretion, immunohistochemical staining ED‐2‐positive macrophages, histology at tissue/material interface. degradation investigated using scanning electron...
Red blood cells (RBCs) attract significant interest as carriers of biomolecules, drugs, and nanoparticles. In this regard, versatile technologies to attach molecules ligands the RBC surface are great importance. Reported here is a fast efficient painting strategy RBCs, factors that control stability circulation properties modified RBCs in vivo. Distearoyl phosphatidylethanolamine anchor-conjugated immunoglobulin (IgG) efficiently incorporates membrane following 15-30 min incubation. The...
Circulating tumor cells (CTCs) are exfoliated at various stages of cancer, and could provide invaluable information for the diagnosis prognosis cancers. There is an urgent need development cost-efficient scalable technologies rare CTC enrichment from blood. Here we report a novel method isolation excess blood using gas-filled buoyant immuno-microbubbles (MBs). MBs were prepared by emulsification perfluorocarbon gas in phospholipids decorated with anti-epithelial cell adhesion molecule...
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8 + T cells play a vital role. Nonetheless, the characterization specificity and TCR composition targeting non-spike protein before after infection remains incomplete. Here, we analyzed recognizing six epitopes from nucleocapsid (N) found that slightly increased frequencies N-recognizing but significantly enhanced activation-induced proliferation compared to uninfected donors. N-specific their...
Abstract Electrically conducting polypyrrole (PPy) and its composite materials are useful in interfacing electrical components cells or living tissue. In recent years, significant efforts have been made to bioactivate PPy by incorporating biomolecules. The main objective of this work was chemically particules fibronectin (FN) bovine serum albumin (BSA). Modified particles were synthesized through a water‐in‐oil emulsion polymerization. XPS FTIR confirmed the presence biomolecules on...
To study the fire resistance of castellated composite beams with semi-rigid restraints, temperature rise tests constant loads were performed on two full-scale circular holes and restraints to compare influence whether stiffeners set or not under beams. The results indicate that during fire, primary failure mode is buckling web lower flange in negative moment zone at beam end. Composite exhibited less than those without stiffeners; for steel stiffeners, show overall lateral instability....
Abstract Recently a method that uses water droplets at the air–solution interface as an ordered template was reported for preparation of micrometer‐size honeycomb structures. Here we show can also be used formation honeycomb‐like porous films from random copolymers with certain hydrophilicity, besides those polymers defined structures such block copolymers, starlike homopolymers, amd amphiphilic polymers. This demonstrates stabilization is key factor regular structure. Also indicate size and...
The SPB@CdS nanoparticles exhibit controllable and reversible photoluminescence with pH as a trigger strong photochemical stability in basic solution.
The construction of engineered bone mostly focuses on simulating the extracellular matrix (ECM) for proper biological activity. However, complexity architecture and variability mechanical properties natural bones are related to individual differences in age, nutritional state, loading disease status. Defect substitutions should be normed with host bone, balancing architectural adaption, as well Using a freeform fabrication (FFF) method, we prepared polycaprolactone (PCL) scaffolds different...
Abstract Stimulation of human primary T cells with immobilized anti-CD3 and anti-CD28 Abs in vitro provide a system to study cell activation proliferation an avenue for expanding immunotherapy. Magnetic beads conjugated (Dynabeads Human T-Activator [D-TCA]) have been golden standard stimulating vitro. In this study, we report that application using on lipid microbubbles (microbubble-based activator [MB-TCA]) stimulate naive resulted expansion superior D-TCA. 56-d cultures three repeated...
Abstract Background Cytomegalovirus (CMV) infection leads to effector memory CD8 + T cell expansion and is associated with immune dysfunction in older adults. However, the molecular alterations of CMV-specific cells CMV infected healthy young middle-aged adults has not been fully characterized. Results We compared specific for a epitope (pp65 495-503 , NLV) an influenza A virus (IAV) (M1 58-66 GIL) from same serum positive anti-CMV IgG. Compared IAV-specific cells, contained more...