A5038782753- Cerebrospinal fluid and hydrocephalus
- Alzheimer's disease research and treatments
- Fetal and Pediatric Neurological Disorders
- Multiple Sclerosis Research Studies
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Neurological and metabolic disorders
- Elder Abuse and Neglect
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic and Kidney Cyst Diseases
- Amyotrophic Lateral Sclerosis Research
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Healthcare Decision-Making and Restraints
University of Helsinki
2024-2025
Oulu University Hospital
2024-2025
University of Oulu
2024-2025
University of Eastern Finland
2024
Helsinki University Hospital
2024
Kuopio University Hospital
2024
Institute for Molecular Medicine Finland
2024
Large-scale genome-wide studies of chronic hydrocephalus have been lacking. We conducted a association study (GWAS) in normal pressure (NPH).
Current epidemiologic data of early-onset dementia (EOD), characterized by the onset disease before age 65, are notably scarce.
ABSTRACT Background The treatment of relapsing‐remitting multiple sclerosis (RRMS) is changing. There are limited data about initial RRMS in Finland. Objective Our objectives were to study the trends disease‐modifying treatments (DMTs) for patients with from 2013 2022, delays, factors associated DMT choice, switch patterns, and effect COVID‐19 pandemic. Methods This retrospective register used secondary Finnish MS register. DMTs classified into medium‐efficacy (meDMTs; beta interferons,...
Heterozygous CWH43 loss-of-function (LOF) variants have been identified as iNPH risk factors, with 10–15% of patients carrying these in cohorts from the US. Mouse model harboring LOF display a hydrocephalic phenotype ventricular cilia alterations. Our aim was to study effect on disease and clinical Finnish Norwegian cohorts. We analyzed frameshift deletions (4:49032652 CA/C, Leu533Ter 4:49061875 Lys696AsnfsTer23) Kuopio NPH registry (n = 630) FinnGen (iNPH n 1 131, controls 495 400), EADB...
ABSTRACT Introduction Literature on criminal behavior preceding a neurodegenerative disease diagnosis is insufficient. Some studies suggest increased crime rates among patients with frontotemporal dementia (FTD). Methods Patients diseases were gathered from Kuopio and Oulu University Hospitals compared nonselective general population data Statistics Finland ( N = 24,144). Clinical linked to the Finnish national register of police‐reported crimes. Results In total, 2424 participants included....
Abstract C9orf72 hexanucleotide repeat expansion (HRE) is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. The role microglia in these HRE-associated diseases understudied. To elucidate effects HRE on microglia, we have characterized human induced pluripotent stem cell-derived (iMG) from behavioral variant dementia (bvFTD) patients carrying the HRE. iMG were compared to healthy controls sporadic bvFTD patients. phenotypes analyzed using bulk RNA sequencing,...