A5067068981- Macrophage Migration Inhibitory Factor
- Acute Myeloid Leukemia Research
- Cancer therapeutics and mechanisms
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Microtubule and mitosis dynamics
- Synthesis of heterocyclic compounds
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Chemical Synthesis and Analysis
- Luminescence and Fluorescent Materials
- Neuroblastoma Research and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Polyamine Metabolism and Applications
- Cancer-related Molecular Pathways
- Nuclear Receptors and Signaling
Semmelweis University
2018-2024
Vichem Chemie (Hungary)
2024
Abstract Treatment-naïve small cell lung cancer (SCLC) is typically susceptible to standard-of-care chemotherapy consisting of cisplatin and etoposide recently combined with PD-L1 inhibitors. Yet, in most cases, SCLC patients develop resistance first-line therapy alternative therapies are urgently required overcome this resistance. In study, we tested the efficacy dinaciclib, an FDA-orphan drug inhibitor cyclin-dependent kinase (CDK) 9, among other CDKs, SCLC. Furthermore, report on a newly...
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity. MIF exerts unique tautomerase enzymatic activity that has relevance concerning its multiple functions and small molecule inhibitors have been proven to block effects. Here we demonstrate some of the E-2-arylmethylene-1-tetralones their heteroanalogues efficiently bind MIF’s active site inhibit tautomeric (enolase, ketolase activity) functions. A set synthesised derivatives, namely...
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with enzymatic activities. Anti-inflammatory effects of MIF enzyme inhibitors indicate link between its cytokine- and catalytic Herein the synthesis, docking, bioactivity substituted benzylidene-1-indanone -1-tetralone derivatives as MIF-tautomerase reported. Many these benzylidene-1-tetralones -indan-1-ones were potent (IC50 < 10 μmol/L), most 1-indanone 16 20. Some compounds acted selective enolase or ketonase...
Oligoamines in cellular metabolism carry extremely diverse biological functions (i.e., regulating Ca