A5020000954- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroendocrine regulation and behavior
- Gut microbiota and health
- Birth, Development, and Health
- Attention Deficit Hyperactivity Disorder
- Suicide and Self-Harm Studies
- Child and Adolescent Psychosocial and Emotional Development
- Cannabis and Cannabinoid Research
- Adolescent and Pediatric Healthcare
- Resilience and Mental Health
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Advanced SAR Imaging Techniques
- Pelvic floor disorders treatments
- Adolescent Sexual and Reproductive Health
- Infant Nutrition and Health
- Pregnancy and Medication Impact
- Anesthesia and Neurotoxicity Research
- COVID-19 and Mental Health
- Cognitive Functions and Memory
- Prenatal Substance Exposure Effects
- Food Security and Health in Diverse Populations
- Posttraumatic Stress Disorder Research
Brigham and Women's Hospital
2025
Harvard University
2025
The Ohio State University Wexner Medical Center
2018-2024
Institute for Behavioral Medicine
2018-2024
The Ohio State University
2018-2024
Abstract Prenatal stress (PNS) is associated with neuropsychiatric disorders in offspring, including anxiety, depression, and autism spectrum disorders. There mounting evidence that these behavioral phenotypes have origins utero . Maternal microbes, inflammation, serotonergic dysfunction been implicated as potential mediators of the consequences PNS; whether how systems interact unclear. Here, we examine effects PNS using late-gestation maternal restraint wild-type (WT), germ-free (GF), CCL2...
Psychosocial stress and mood-related disorders, such as depression, are prevalent vulnerability to these conditions is heightened during pregnancy. induces consequences via several mechanisms including the gut microbiota-brain axis associated signaling pathways. Previous preclinical work indicates that prenatal alters maternal microbial composition impairs offspring development. Importantly, although fecal vaginal microenvironments undergo alterations across pregnancy, we lack consensus...
Abstract Background Posttraumatic stress disorder (PTSD) is one of the most sex-polarized psychiatric disorders, with women exhibiting twice prevalence men. The biological mechanisms underlying this sex disparity are not fully understood. Growing evidence suggests that alterations stress-buffering endocannabinoid (eCB) system and heightened inflammation central to PTSD pathophysiology may contribute sex-biases in risk severity. Here, we examined sex-differences levels circulating eCBs...
Abstract Maternal stress during pregnancy is widespread and associated with poor offspring outcomes, including long-term mental health issues. Prenatal stress-induced fetal neuroinflammation thought to underlie aberrant neurodevelopment derive from a disruption in intrauterine immune homeostasis, though the exact origins are incompletely defined. We aimed identify divergent microbial metagenome profiles of stressed gestating mice that may trigger detrimental inflammatory signaling at...
Attention Deficit-Hyperactivity Disorder (ADHD) and Posttraumatic Stress (PTSD) are often comorbid share a common core of symptoms. However, sex gender-related factors significantly influence their prevalence, clinical presentation, diagnosis. Here, we conducted systematic literature review meta-analysis to examine differences in ADHD/PTSD comorbidity during childhood adulthood. A scoping PsycINFO PubMed yielded 13 eligible studies with complete outcome data. We fixed-effects meta-analyses...
Abstract Prenatal stress (PNS) has widespread effects on offspring, including aberrant immune development and behavioural deficits. The microbiome is a mediator of the dissemination to offspring through immunomodulation metabolite production. Metabolites derived from mother their gut microbiota pass foetus can affect nervous development. Stress affects abundance such metabolites, tryptophan (Trp) pathway, which are involved in system function. We hypothesized that PNS associated with...
Stressor exposure increases colonic inflammation. Because inflammation leads to anxiety-like behavior, we tested whether stressor in mice recovering from dextran-sulfate-sodium (DSS)-induced colitis enhances behavior. Mice received 2% DSS for five consecutive days prior being exposed a social-disruption (SDR) (or left undisturbed). After exposure, their behavior was and assessed via histopathology inflammatory-cytokine measurement the serum colon. Cytokine chemokine mRNA levels colon,...
INTRODUCTION: Pregnancy is a period of significant stress and weight gain; however, the effect vaginal gut microbiome on pregnancy, depression, stress, neonate not completely understood. METHODS: An IRB-approved prospective cohort study was performed for pregnant individuals their neonates. The Perceived Stress Scale (PSS) Center Epidemiologic Studies Depression (CES-D) surveys were administered in antepartum postpartum patient, fecal samples collected, umbilical cord blood specimens also...
The first two years of the COVID-19 pandemic and subsequent health mandates resulted in significant disruptions to daily life, creating a period heightened psychosocial stress myriad aspects. Understanding impact this on pregnant individuals' bacteriomes is crucial as pregnancy vulnerability its sequelae, anxiety mood disorders, which have been demonstrated alter gut microbiome composition. In prospective cohort study (N = 12–26) conducted from February 2019 August 2021, we examined...
Hyperemesis Gravidarum (HG) is a debilitating condition characterized by severe nausea and vomiting during pregnancy, yet its severity often misunderstood or underestimated both the public healthcare providers. This lack of understanding can lead to misdiagnosis, inadequate treatment, undue suffering for individuals experiencing HG. study explores online discourse surrounding HG identify key themes related patient experiences perceptions. Using Twint0 application, we collected 5,856 relevant...