A5051481595- Single-cell and spatial transcriptomics
- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Nerve injury and regeneration
- Congenital heart defects research
- Phytochemistry and Bioactive Compounds
- Estrogen and related hormone effects
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Neurotransmitter Receptor Influence on Behavior
- Down syndrome and intellectual disability research
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Magnolia and Illicium research
- Nuclear Receptors and Signaling
- Pluripotent Stem Cells Research
University of Luxembourg
2020-2021
American University of Beirut Medical Center
2021
University of Freiburg
2016
Université de Strasbourg
2015-2016
Inserm
2015-2016
Centre National de la Recherche Scientifique
2015
Institut de génétique et de biologie moléculaire et cellulaire
2015
The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable aneuploidy. In contrast to trisomy, complete monosomy (M21) Hsa21 lethal, and only partial or mosaic seen. Both conditions lead variable physiological abnormalities with constant intellectual disability, locomotor deficits, altered muscle tone. To search for dosage-sensitive genes involved in DS M21 phenotypes, we created two new mouse models: Ts3Yah carrying a tandem duplication Ms3Yah...
The natural neurosteroid allopregnanolone exerts beneficial effects in animal models of neurodegenerative diseases, nervous system injury and peripheral neuropathies. It not only has anti-apoptotic activity, but also promotes proliferation progenitor cells. With respect to using it as a therapeutic tool, such pleiotropic actions might create unwanted side effects. Therefore, we have synthesized analogs analyzed their neuroprotective proliferative identify compounds with higher efficiency...
Dopaminergic neurons in the midbrain are of particular interest due to their role diseases such as Parkinson's disease and schizophrenia. Genetic variation between individuals can affect integrity function dopaminergic but DNA variants molecular cascades modulating other cells types ventral remain poorly defined. Three genetically diverse inbred mouse strains - C57BL/6J, A/J, DBA/2J differ significantly genomes (∼7 million variants), motor cognitive behavior, susceptibility neurotoxins. To...
Abstract Dopaminergic neurons (DA neurons) are controlled by multiple factors, many involved in neurological disease. Parkinson's disease motor symptoms caused the demise of nigral DA neurons, leading to loss striatal dopamine (DA). Here, we measured concentration dorsal striatum 32 members Collaborative Cross (CC) family and their eight founder strains. Striatal varied greatly founders, differences were highly heritable inbred CC progeny. We identified a locus, containing 164 genes, linked...
Abstract Mouse models have been instrumental in understanding genetic determinants of aging and its crucial role neurodegenerative diseases. However, few studies analyzed the evolution mouse brain over time at baseline. Furthermore, are commonly conducted on C57BL/6 strain, limiting analysis to a specific background. In Parkinson’s disease, gradual demise nigral dopaminergic neurons mainly contributes motor symptoms. Interestingly, decline neuron function integrity is also characteristic...
Abstract Background Dopaminergic neurons in the midbrain are of particular interest due to their role diseases such as Parkinson’s disease and schizophrenia. Genetic variation between individuals can affect integrity function dopaminergic but DNA variants molecular cascades modulating other cells types ventral remain poorly defined. Three genetically diverse inbred mouse strains — C57BL/6J, A/J, DBA/2J differ significantly genomes (~7 million variants), motor cognitive behavior,...
Abstract The features of dopaminergic neurons (DAns) nigrostriatal circuitry are orchestrated by a multitude yet unknown factors, many them genetic. Genetic variation between individuals at baseline can lead to differential susceptibility and severity diseases. As decline DAns, characteristic Parkinson’s disease, heralds significant decrease in dopamine level, measuring reflect the integrity DAns. To identify novel genetic regulators we used Collaborative Cross (CC) mouse strains as model...