A5008567345- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- COVID-19 Clinical Research Studies
- Otolaryngology and Infectious Diseases
- Tryptophan and brain disorders
- Long-Term Effects of COVID-19
- IL-33, ST2, and ILC Pathways
- Respiratory and Cough-Related Research
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Impact on Reproduction
- Gastrointestinal motility and disorders
- Dysphagia Assessment and Management
- Oral microbiology and periodontitis research
- Gastroesophageal reflux and treatments
- COVID-19 and healthcare impacts
- Pharmacological Receptor Mechanisms and Effects
- Cytokine Signaling Pathways and Interactions
- Viral gastroenteritis research and epidemiology
- Dental Research and COVID-19
- Oral Health Pathology and Treatment
- Tracheal and airway disorders
- Inflammatory Bowel Disease
Ministry of Health of the Russian Federation
2025
Moscow State University of Medicine and Dentistry
2021-2024
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has significantly impacted global healthcare, underscoring importance of exploring virus's effects on infected individuals beyond treatments and vaccines. Notably, recent findings suggest that can infect gut, thereby altering gut microbiota. This study aimed to analyze microbiota composition differences between patients experiencing mild severe symptoms. We conducted 16S rRNA metagenomic sequencing fecal samples from 49 43 cases upon...
The majority of metagenomic studies are based on the study bacterial biota. At same time, COVID-19 pandemic has prompted interest in both individual fungal pathogens and communities (i.e., mycobiome) as a whole. Here, this work, we investigated human gut mycobiome during COVID-19. Stool samples were collected from patients at two time points: admission to hospital (the first point) discharge second point). results revealed that Geotrichum sp. is more represented group with Therefore,...
Antimicrobial resistance poses a serious threat to global public health. The COVID-19 pandemic underscored the need monitor dissemination of antimicrobial genes and understand mechanisms driving this process. In study, we analyzed changes oropharyngeal fecal resistomes patients with undergoing therapy in hospital setting. A targeted sequencing panel 4,937 was used comprehensively characterize resistomes. Our results demonstrated that resistome is homogeneous, showing low variability over...
Relevance. The COVID-19 pandemic caused by the SARS-CoV-2 virus has demonstrated critical importance of understanding mechanisms transmission and finding effective methods prevention. Particular attention been paid to role oral hygiene, as cavity serves a major route transmission. Studies show that composition microbiota can influence course outcome disease. Therefore, there is need study effects antiseptics on microbiome, which may offer new opportunities for prevention treatment this...
Aim. Assessment of the prevalence and prognostic value gastroenterological manifestations in patients with COVID-19. Materials methods. A single-center retrospective cohort study was carried out. Only cases laboratory confirmed detection SARS-CoV-2 virus RNA using polymerase chain reaction oro-/nasopharyngeal smear samples were subject to analysis. Patients documented (according anamnestic data and/or according examination during hospitalization) organic pathology gastrointestinal tract...
<h3>Background</h3> The pathogenesis of Crohn's disease (CD) is considered from a multifactorial perspective with an undeniable contribution the genetic component. various ATG16L1 gene variants are strongly associated susceptibility to in different populations. It also known that cytokine profile as complex signature inflammatory process both locally and organism. aim study was assess local systemic L1 ileal CD patients clinical remission. <h3>Methods</h3> Serum samples, rectal tissue...
Aim. To evaluate the efficacy of Saccharomyces boulardii (S. boulardii) CNCM I-745 probiotic drug in preventing and treating diarrhea hospitalized patients with COVID-19. Materials methods. A prospective comparative study was conducted two parallel groups. The included males females aged 18 to 60 following diagnosis confirmed by polymerase chain reaction: U07.2 Coronavirus infection COVID-19, caused SARS-CoV-2 virus (grade 13 pneumonia according CT scan). All received antibiotic therapy....
На настоящий момент этиопатогенез функциональной диспепсии (ФД) рассматривается как сложный многогранный и мозаичный процесс, при-чинно-следственные связи которого продолжают активно изучаться. Предполагается, что генез моторных сенситивных нарушений желудка, свой-ственных для ФД, может заключаться в комплексных механизмах, базирующихся на изменениях качественного количественного состава микро-флоры желудка тонкой кишки под воздействием моторики нижележащих отделов желудочно-кишечного тракта...
<title>Abstract</title> Background The global healthcare landscape has changed dramatically as a result of the COVID-19 pandemic caused by SARS-CoV-2. In addition to focusing on treatments and vaccines, it is crucial investigate effects virus infected individuals. Recent studies have discovered that SARS-CoV-2 can infect gut, affecting gut microbiota revealing new aspect virus. This study examined differences in composition between patients with severe mild conditions. Methods this study, we...
Introduction. The use of remdesivir in patients with the new coronavirus infection COVID-19 is known to improve prognosis disease. But there not enough data on efficacy and safety from Russia. Aim. To evaluate COVID-19. Materials methods. A comparative prospective study was conducted two parallel groups. enrolled 300 diagnosed (grade 1–3 severe pneumonia according CT scan), who were divided into groups (n = 150 each) prescription remdesivir. Treatment assessed by recording cases disease...
Aim. To identify features of the taxonomic composition oropharyngeal microbiota COVID-19 patients with different disease severity. Materials and methods. The study group included 156 hospitalized confirmed diagnosis in clinical medical center Yevdokimov Moscow State University Medicine Dentistry between April June 2021. There were 77 mild pneumonia according to CT (CT1) 79 moderate severe (CT2 CT3). Oropharyngeal swabs taken when patient was admitted hospital. Total DNA isolated from...