A5025800756- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Biliary and Gastrointestinal Fistulas
- Abdominal vascular conditions and treatments
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Genetic factors in colorectal cancer
- Pregnancy and Medication Impact
- Tracheal and airway disorders
- Colorectal Cancer Surgical Treatments
- Foreign Body Medical Cases
- Reproductive System and Pregnancy
- Vascular Malformations and Hemangiomas
- Cytomegalovirus and herpesvirus research
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Organ Transplantation Techniques and Outcomes
Hospitais da Universidade de Coimbra
2015-2025
University of Coimbra
2017-2024
University Gastroenterology
2017-2022
Faculty (United Kingdom)
2022
University of Beira Interior
2017
The long-term safety of exposure to anti-tumor necrosis factor (anti-TNFα) drugs during pregnancy has received little attention. We aimed compare the relative risk severe infections in children mothers with inflammatory bowel disease (IBD) who were exposed anti-TNFα utero that not drugs.Retrospective multicenter cohort study. Exposed cohort: from IBD receiving medication (with or without thiopurines) at any time 3 months before conception. Non-exposed treated agents thiopurines cumulative...
Acute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables some of them are only complete within 48 h admission. Red cell distribution width (RDW) a simple routine parameter that seems to be related inflammatory status. Our aims were evaluate the diagnostic value RDW in mortality AP comparing other prognostic scoring systems.Retrospective case-control study total 312 patients admitted between 2014 2016. Patients severe...
Spontaneous bacterial peritonitis is the most common infectious complication in cirrhosis. fungal rare and remains unknown. In this work, spontaneous as well risk factors prognosis are characterized.A retrospective case-control study of 253 consecutive admissions by cirrhotic patients was carried out between 2006 2015. Comparison with (cases) positive microbiologic ascitic fluid culture (controls) performed. Variables such sociodemographic clinical features, cirrhosis etiology, liver...
Introduction: Malignant melanoma of the esophagus is an uncommon cause dysphagia and accounts for only 0.1-0.2% esophageal neoplasms. Diagnosis based on esophagogastroduodenoscopy (EGD) with biopsies immunohistochemical analysis, latter being crucial in amelanocytic variant. Gastrointestinal melanomas are more invasive comprise poorer prognosis than cutaneous melanomas. Case presentation: The authors present case a 70-year-old woman admitted to emergency department progressive 2 months...
Objective: To determine the diagnostic accuracy of Tokyo guidelines (TG) 2018/2013 (TG18/TG13) and predictors poor prognosis in acute cholangitis.Methods: Retrospective 1-year study consecutive hospital admissions for cholangitis. Prognosis was defined terms 30 d in-hospital mortality.Results: Of 183 patients with cholangitis, based on Charcot’s triad, TG07 TG18/TG13 67.8, 86.9 92.3% (p < .001), respectively. Regarding severity TG18/TG13, 30.6% cases were severe. A found 10.9% patients....
The prevalence of adverse food reactions (AFR) has been increasing in the western world. Clinical manifestations are diversified and it may not be possible to clinically discriminate between IgE non-IgE mediated AFR. In Portugal, AFR allergies children is known. Thus, objectives this study were determine central Portugal.Point 3-11 year-old schoolchildren from Central Portugal. Food-related questionnaires, skin prick tests (SPT) with foods determination food-specific levels performed.Of 4045...
Introduction and aim. The association between lysosomal acid lipase (LAL) activity liver steatosis or fibrosis is poorly studied. aim of our study was to determine the predictive power LAL for cryptogenic significant fibrosis/cirrhosis. Material methods. Cross-sectional observational 101 adult patients with unexplained elevated enzymes/hepatomegaly without dyslipidemia submitted determination LIPA gene (E8SJM-C.894G^A) mutation. Seventy-one underwent biopsy FibroScan®. Patients an...
An 88-year-old man presented with haematemesis haemodynamic stability requiring transfusion of 5 units blood. Physical examination was unremarkable. Upper endoscopy identified a fistulous opening in the proximal second part duodenum (D2) an oozing bleed and blood clots. A computed tomography (CT)-angiogram revealed 18mm cystic artery pseudoaneurysm next to communication between gallbladder D2, allowing passage large stone (Bouveret syndrome). The patient successfully underwent emergent...
<b><i>Background:</i></b> <i>Chlamydia trachomatis</i>-lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) and an uncommon cause of proctitis. The diagnosis requires high index clinical suspicion, since the clinical, imaging, endoscopic, histological findings can mimic multiple benign or malignant conditions like inflammatory bowel disease rectal neoplasms. <b><i>Case Presentation:</i></b> We present case...
copy was performed showing a large, yellowish, and pedunculated subepithelial lesion with 30 mm of head diameter 45 stalk length, located at the sigmoid colon (Fig. 1a-c).Considering benignity in symptomatic patient, it decided to perform polyp resection using minimally invasive technique -"loopand-let-go."A 30-mm endoloop ® (Olympus, Tokyo, Japan) maneuvered capture lipoma's then carefully placed base.A visible reduction vascularization verified following sheathcontrolled closure 1d-g).A...
Cytomegalovirus (CMV) gastrointestinal disease usually arises in patients with immunodeficiency or immunosuppression, being rare immunocompetent hosts. Although increasing incidence, few cases of CMV have been described among young healthy patients. Currently, there is uncertainty approaching these patients, including the need for antiviral therapy that remains to be established. This case report describes a ulcerative oesophagitis patient good evolution no therapy, youngest reported...
Endoscopy remains the exam of choice in evaluation activity Crohn's disease (CD) after surgery (ACD-AS). However, intestinal ultrasound (IUS) may represent a noninvasive alternative. The objective this study is to determine diagnostic accuracy modality compared endoscopy.This cross-sectional study, comprising period 14 months, carried out patients with established CD and ileocecal resection due disease. IUS (HI-VISION Avius®, Tokyo, Japan) was performed linear probe B-mode/Doppler prior...
The use of fecal microbiota transplantation in recurrent Clostridium difficile infection and coexistent inflammatory bowel disease remains unclear. A 61-year-old man with ulcerative pancolitis was diagnosed a third recurrence infection, previously treated metronidazole, vancomycin fidaxomicin. Fecal an unrelated healthy donor performed by the lower route. After twelve month follow-up, patient asymptomatic without relapses or flare-ups. is relatively simple to perform, well-tolerated, safe...
Cholangiocarcinoma is an uncommon tumor, often diagnosed in the context of obstructive jaundice. Brain metastasis rarely occurs with cerebellum being a rare site spread this type tumor. Few cases cholangiocarcinoma have been reported literature and tumor associated very poor outcome. We present form clinical presentation neurologic symptoms due to cerebellar metastases.
Groove pancreatitis is an uncommon cause of chronic that affects the groove anatomical area between head pancreas, duodenum, and common bile duct.
Colonic lipomas are common mesenchymal tumours. They usually asymptomatic and incidentally diagnosed during endoscopic or radiological examinations. Taking into account their typical features benign nature, tissue sampling, resection follow-up generally not required.A 61-year-old woman with poor surgical fitness presented colonic subocclusion lower gastrointestinal bleeding. A colonoscopy performed 1 month earlier showed a large polypoid lesion necrotic ulcerated areas occupying the lumen of...
A 51-year-old man with no relevant medical history presents to the emergency department complaining of a recent worsening few months upper abdominal pain back radiation and postprandial fullness, without B symptoms. Laboratory analysis showed hyperamylasaemia, elevated lactate dehydrogenase inflammatory parameters. Abdominal ultrasonography revealed heterogeneous solid mass in spleen/splenic hilum pancreatic parenchyma continuity biliary tract dilation or gallstones. mild acalculous acute...
.We present the case of a 46-year-old female with dysphagia to solids and retrosternal pain that worsened after eating. Due mediastinal lymphadenopathies, she underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) 3 weeks before, mentioning complaints started afterwards. On physical examination had fever (38.3ºC). Gastroscopy revealed three 10-20mm fistulous orifices purulent discharge at 26-32cm from incisors another four partially covered by fibrin in distal...