A5066222789- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Mitochondrial Function and Pathology
- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Balance, Gait, and Falls Prevention
- Pluripotent Stem Cells Research
- Family and Disability Support Research
- Musculoskeletal pain and rehabilitation
- Intensive Care Unit Cognitive Disorders
- Multiple Sclerosis Research Studies
- Long-Term Effects of COVID-19
- Autism Spectrum Disorder Research
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Causal Inference Techniques
- Dementia and Cognitive Impairment Research
- Biomedical Ethics and Regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Neurology and Historical Studies
- Cardiovascular and exercise physiology
- Shoulder Injury and Treatment
Cardiff University
2016-2025
Google (United States)
2024
Newcastle University
2023
Centre National de la Recherche Scientifique
2022
CEA Paris-Saclay
2022
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2022
Université Paris-Saclay
2022
Columbia University
2017-2020
The Ohio State University
2020
Wayne State University
2017-2020
The European Huntington's Disease Network (EHDN) commissioned an international task force to provide global evidence-based recommendations for everyday clinical practice treatment of disease (HD). objectives such guidelines are standardize pharmacological, surgical and non-pharmacological regimen improve care quality life patients. A formalized consensus method, adapted from the French Health Authority was used. First, national committees (French English Experts) reviewed all studies...
A direct quantitative measurement of locomotor activity in an individual's own environment over extended period may help evaluating the impact impairments neurological disorders.To investigate reliability and validity monitoring patients healthy subjects.Initial studies were completed on 10 subjects mobility restricted patients. Validity was investigated using 7 days ambulatory with Step Watch( step monitor, laboratory based measures gait Rivermead Mobility Index (RMI) multiple sclerosis,...
Objective: The aim of this study was to explore feasibility, safety and outcome an exercise intervention in people with Huntington’s disease. Design: A randomized controlled pilot trial. Setting: home-based programme. Subjects: total 25 subjects early mid-stage Intervention: Subjects were randomly allocated either ( n = 13) or a control group 12). the asked perform exercises at home three times week for eight weeks using DVD, specifically developed purpose. received their usual care....
<h3>Objective:</h3> The aim of this study was to estimate the frequency falls in people with Huntington9s disease (HD) and make a preliminary assessment tools appropriate for assessing risk falling. <h3>Design:</h3> Observational study. <h3>Setting:</h3> Hospital clinic. <h3>Subjects:</h3> 24 HD. <h3>Main measures:</h3> Balance assessed using Berg Scale (BBS) Timed "Up & Go" (TUG) test. Walking speed over 10 m recorded. Long-term monitoring walking activity undertaken. Unified Huntington...
The beneficial role of exercise as a treatment approach in Huntington's disease (HD) has support from both preclinical work and small-scale studies; however, there have been no controlled studies gym-based people with HD. This phase 2 randomized trial (ISRCTN 59910670) assessed feasibility, safety, acceptability, benefit structured program.Thirty-one participants (16 men; mean [SD] age = 50.4 [11.4] years) were randomly allocated to intervention (n 16) or control group (usual care; n 15)....
A cross-sectional study between subgroups of nonspecific chronic low back pain (NSCLBP) and asymptomatic controls.To investigate NSCLBP subgroup differences in spinal position sense trunk muscle activity when repositioning thoracic lumbar spine into neutral (midrange) during sitting standing.Patients with report aggravation symptoms standing. Impaired motor control NSCLBP, associated standing postures nearer the end range motion, may be a contributing factor. Rehabilitation improving is...
This study aimed to evaluate the feasibility and benefit of a structured exercise intervention in people with Huntington's Disease (HD).This was conducted at 6 sites, participants were randomized into either or control (usual care) groups, assessed baseline, 13 26 weeks. The 12 week, three times per week progressive program, including aerobic (stationary cycling) upper lower body strengthening tapered 1:1 support for 20 36 sessions.314 adults eligibility: 248 did not meet inclusion criteria,...
Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback (NF) uses feedback of the patient's own brain activity to self-regulate networks which in turn could lead a change behavior and clinical symptoms. The objective was determine effect NF motor training (MOT) alone on non-motor functions Parkinson's Disease (PD) 10-week small Phase I randomized controlled trial.
Purpose. Physiotherapists frequently prescribe home exercise programmes for individuals with Parkinson's disease (PD) and Huntington's (HD); however, little is known about clients' perceptions of such any barriers that may affect participation compliance.
Sub-clinical muscle involvement, including myopathic changes and mitochondrial dysfunction of skeletal muscle, has been reported in people with Huntington's disease (HD). Muscle strength was evaluated using a hand-held dynamometer. Reliability validity HD were determined.Isometric 6 lower limb groups measured 20 matched healthy controls. People the Unified Disease Rating Scales (UHDRS). Within session reliability intra-class correlation coefficients (ICC) calculated. Discriminant convergent...
Huntington's disease (HD) is a neurodegenerative caused by mutation within the huntingtin gene that induces degeneration striatal nuclei, progressing to widespread brain atrophy and death. The neurodegeneration produces symptoms reflect corticostriatal disconnection syndrome involving motor, cognitive psychiatric disturbance. Environmental enrichment has been demonstrated be beneficial patients with neurological disorders, exercise being central this effect. Rodent studies have confirmed...
Clinical intervention trials in people with Huntington disease (HD) have been limited by a lack of reliable and appropriate outcome measures.The purpose this study was to determine the reliability minimal detectable change (MDC) various measures that are potentially suitable for evaluating physical functioning individuals HD.This multicenter, prospective, observational study.Participants pre-manifest manifest HD (early, middle, late stages) were recruited from 8 international sites complete...
There are few guidelines for clinical trials of interventions prevention post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including patients was convened to generate points consider the design and conduct interventional studies following acute knee injury.An evidence review on injury prevent PTOA presented group, alongside overviews area, potential targets, biomarkers imaging. Working groups considered pre-identified...
22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric remain unexplored. Aims To establish prevalence indicative DCD in children 22q11.2DS examine associations IQ, neurocognition psychopathology.Neurocognitive assessments interviews 70 (mean age 11.2, s.d. = 2.2) 32 control siblings 11.5, 2.1) were carried out their homes. Nine subsequently...
Background Carers report unmet need for occupational therapy services addressing sensory difficulties in autism, yet insufficient evidence exists to recommend a therapeutic approach. Objectives Our aim was determine the clinical effectiveness and cost-effectiveness of integration children with autism across behavioural, functional quality-of-life outcomes. Design We carried out parallel-group randomised controlled trial, incorporating an internal pilot process evaluation. Randomisation...
Abstract Introduction Many Covid‐19 survivors are living with unresolved, relapsing and remitting symptoms no ‘one size’ of treatment is likely to be effective for everyone. Supported self‐management the varied Long Covid (LC) recommended by National Institute Health Care Excellence in United Kingdom. We aimed develop a new personalised support intervention people LC using structured co‐design framework guide replication evaluation. Methods used improvement methodology, Experience‐Based...
Objectives: Investigation of the reliability and validity activity monitoring using a range methods, namely manual counting, self report two commercially available monitors.Study design: Reliability, accuracy study.Methods: Multiple convenience samples healthy subjects were recruited to study. Reliability step count was determined an intraclass correlation coefficient (ICC) (n = 10). Relationships between data from Step Watch™ monitor (SAM) (a) counts 18); (b) second (different) (ActivPAL);...