A5037660240- Estrogen and related hormone effects
- Air Quality and Health Impacts
- Nanoparticles: synthesis and applications
- Cancer-related Molecular Pathways
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Vehicle emissions and performance
- Synthesis and biological activity
- Nanoparticle-Based Drug Delivery
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Energy and Environment Impacts
- Inhalation and Respiratory Drug Delivery
- Graphene and Nanomaterials Applications
- Zebrafish Biomedical Research Applications
- Animal testing and alternatives
- Air Quality Monitoring and Forecasting
- Retinoids in leukemia and cellular processes
- Effects and risks of endocrine disrupting chemicals
- Maritime Transport Emissions and Efficiency
- Cell death mechanisms and regulation
- ATP Synthase and ATPases Research
- Caveolin-1 and cellular processes
Karlsruhe Institute of Technology
2016-2025
University of Turku
2013
UNSW Sydney
2013
University of Helsinki
2013
Åbo Akademi University
2013
Tampere University Hospital
2013
Institute for Molecular Medicine Finland
2013
Tampere University
2013
Turku Centre for Biotechnology
2013
FZI Research Center for Information Technology
1999-2009
Siva Kumar Kolluri, Carsten Weiss, Andrew Koff, and Martin Göttlicher Forschungszentrum Karlsruhe, Institute of Genetics, 76021 Germany; Laboratory Cell Cycle Regulation, Memorial Sloan-Kettering Cancer Center, New York, York 10021 USA
In a retrospective review of the results 3,612 arthroscopic procedures that were performed for treatment an acute or chronic meniscal lesion, with without associated ligamentous we identified eighty tears (in seventy-five patients) had been assumed to be stable. Seventy vertical longitudinal and ten radial tears. The seventy included fifty-two lateral eighteen medial lesions. All in meniscus. Of patients, followed two years. At time follow-up, only six these patients needed additional...
The application of transcranial slow oscillation stimulation (tSOS; 0.75 Hz) was previously shown to enhance widespread endogenous EEG oscillatory activity when applied during a sleep period characterized by emerging activity. Processes memory consolidation typically occurring this state were also enhanced. Here, we show that the same tSOS in waking brain induced an increase oscillations (0.4–1.2 Hz), although topographically restricted fashion. Applied wakefulness tSOS, additionally,...
There is an urgent need to establish a fundamental understanding of the mechanisms nanomaterial (NM) interaction with living systems and environment, in order for regulation NMs keep pace their increasing industrial application. Identification critical properties (physicochemical descriptors) that confer ability induce harm biological crucial, enabling both prediction impacts from related (via quantitative nanostructure–activity relationships (QNARs) read-across approaches) development...
Even before the first vertebrates appeared on our planet, aryl hydrocarbon receptor ( AHR ) gene was present to carry out one or more critical life functions. The vertebrate then evolved take functions of detecting and responding certain classes environmental toxicants. These pollutants include polycyclic aromatic hydrocarbons (e.g., benzo[ a ]pyrene), polyhalogenated hydrocarbons, dibenzofurans, most potent small-molecular-weight toxicant known, 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD...
Background Ship engine emissions are important with regard to lung and cardiovascular diseases especially in coastal regions worldwide. Known cellular responses combustion particles include oxidative stress inflammatory signalling. Objectives To provide a molecular link between the chemical physical characteristics of ship emission they elicit identify potentially harmful fractions shipping aerosols. Methods Through an air-liquid interface exposure system, we exposed human cells under...
Despite the common knowledge that reticuloendothelial system is largely responsible for blood clearance of systemically administered nanoparticles, sequestration mechanism remains a "black box". Using transgenic zebrafish embryos with cell type-specific fluorescent reporters and fluorescently labeled model nanoparticles (70 nm SiO2), we here demonstrate simultaneous three-color in vivo imaging intravenously injected macrophages, scavenger endothelial cells (SECs). The trafficking processes...
In cell culture studies, foetal calf serum (FCS) comprising numerous different proteins is added, which might coat the surface of engineered nanomaterials (ENMs) and thus could profoundly alter their biological activities. this study, a panel industrially most relevant metal oxide nanoparticles (NPs) was screened for toxic effects in A549 lung epithelial cells RAW264.7 macrophages presence absence FCS. medium without FCS amorphous SiO2-NPs were cytotoxic NPs induced significant...
Background: Investigations on adverse biological effects of nanoparticles (NPs) in the lung by vitro studies are usually performed under submerged conditions where NPs suspended cell culture media. However, behaviour such as agglomeration and sedimentation complex suspensions is difficult to control hence deposited cellular dose often remains unknown. Moreover, responses might differ from those observed at physiological settings air–liquid interface. Results: In order avoid problems because...
A central challenge for the safe design of nanomaterials (NMs) is inherent variability NM properties, both as produced and they interact with evolve in, their surroundings. This has led to uncertainty in literature regarding whether biological toxicological effects reported NMs are related specific properties themselves, or rather presence impurities physical such agglomeration particles. Thus, there a strong need systematic evaluation synthesis processing parameters that lead potential...
Abstract We report the straightforward, time‐efficient synthesis of radical core–shell nanoparticles (NPs) by polymerization‐induced self‐assembly. A nitroxide‐containing hydrophilic macromolecular precursor was prepared ring‐opening metathesis copolymerization norbornenyl derivatives TEMPO and oligoethylene glycol chain‐extended in situ with norbornene ethanolic solution, leading to simultaneous amphiphilic block copolymer formation Without any intermediate purification from monomers...
Abstract Background Wood combustion emissions have been studied previously either by in vitro or vivo models using collected particles, yet most studies neglected gaseous compounds. Furthermore, a more accurate and holistic view of the toxicity aerosols can be gained with parallel direct exposure methods. Moreover, modern techniques such as air-liquid interface (ALI) exposures enable better assessment applied than, for example, previous state-of-the-art submerged cell techniques. Methods We...