A5051366519- Autism Spectrum Disorder Research
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Regulation of Appetite and Obesity
- Animal Genetics and Reproduction
- Neurological disorders and treatments
- Neural dynamics and brain function
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Genetic Syndromes and Imprinting
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic function and diabetes
- Hypothalamic control of reproductive hormones
- Nerve injury and regeneration
- Birth, Development, and Health
Neurochlore (France)
2018-2022
Inserm
2010-2017
Aix-Marseille Université
2015-2017
Institut de Neurobiologie de la Méditerranée
2015-2017
Erasmus MC
2015
Université de Montpellier
2010
Institut de Génomique Fonctionnelle
2010
Centre National de la Recherche Scientifique
2010
Abstract Memories are encoded within sparsely distributed neuronal ensembles. However, the defining cellular properties of neurons a memory trace remain incompletely understood. Using fluorescence-based Arc reporter, we were able to visually identify distinct subset lateral amygdala (LA) activated during auditory fear conditioning. We found that Arc- expressing have enhanced intrinsic excitability and preferentially recruited into newly traces. Furthermore, synaptic potentiation thalamic...
Abstract We report that half striatal cholinergic interneurons are dual transmitter and GABAergic (CGINs) expressing ChAT, GAD65, Lhx7, Lhx6 mRNAs, labeled with GAD VGAT, generating monosynaptic cholinergic/GABAergic currents an inhibitory pause response. Dopamine deprivation increases CGINs ongoing activity abolishes inhibition including the cortico-striatal because of high [Cl − ] i levels. also dramatically dendritic arbors interconnections probability, suggesting formation a dense...
There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine hypothalamus. However, recognition that growth hormone (GH) cells arranged functionally organized networks raises possibility responses network different males and females. We studied this directly monitoring calcium an identical GH-releasing (GHRH) stimulus populations individual GH slices taken from male female murine GH-eGFP...
Ghrelin targets the arcuate nucleus, from where growth hormone releasing (GHRH) neurones trigger GH secretion. This hypothalamic nucleus also contains neuropeptide Y (NPY) neurons which play a master role in effect of ghrelin on feeding. Interestingly, connections between NPY and GHRH have been reported, leading to hypothesis that axis feeding circuits might be co-regulated by ghrelin.Here, we show stimulates firing rate identified neurons, transgenic GHRH-GFP mice. stimulation is prevented...
Abrupt neuronal growth and cerebral volume increase during labor birth in a rat model of autism spectrum disorder.
The spontaneous activity pattern of adult dopaminergic (DA) neurons the substantia nigra pars compacta (SNc) results from interactions between intrinsic membrane conductances and afferent inputs. In SNc DA neurons, low-frequency tonic background is generated by pacemaker mechanisms, whereas burst generation depends on intact synaptic inputs in particular glutamatergic ones. Tonic release striatum during pacemaking required to maintain motor activity, firing evokes phasic release, necessary...
The neuronal population of the subthalamic nucleus (STN) has ability to prolong incoming cortical excitation. This could result from intra-STN feedback combination inducible genetic fate mapping techniques with in vitro targeted patch-clamp recordings, allowed identifying a new type STN neurons that possess highly collateralized intrinsic axon. time window birth dates was found be narrow (E10.5-E14.5) very few born at E10.5 or E14.5. mapped E11.5-12.5 included 20% profuse axonal branching...
Growth hormone (GH) is the key involved in regulation of growth and metabolism, two functions that are highly modulated during infancy. GH secretion, controlled mainly by releasing (GHRH), has a characteristic pattern postnatal development results peaks blood concentration at birth puberty. A detailed knowledge electrophysiology GHRH neurons necessary to understand mechanisms regulating secretion. Here, we describe unique electrophysiological properties their gonadal hormones. Using...
Although several observations suggest that the constitutive biological, genetic or physiological changes leading to autism spectrum disorders (ASD) start in utero, their early impact on number and density of neurons brain remains unknown. Using fate mapping associated with immunollabeling-enabled three-dimensional imaging solvent-cleared organs (iDISCO) clearing method we identified counted a selective population neocortical hippocampal pyramidal utero valproate (VPA) mouse model autism. We...