A5040459072- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- CAR-T cell therapy research
Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and thought to drive tumor development progression. Characterization of LIF clinical-stage inhibitors would increase our understanding as therapeutic target.We first tested the association expression transcript signatures representing multiple processes regulating Next, we developed MSC-1, high-affinity antibody that potently inhibits signaling it immune competent animal models cancer.LIF...
<p>Supplementary Figure 1. Transcriptomic analysis demonstrates an enrichment of immunological pathways in high LIF tumors. Supplementary 2. transcripts are associated with a panel immunosuppressive macrophage/myeloid signatures across human tumor indications. 3. specifically suppressive macrophage 4. tend to be highly expressed aggressive 5. drives polarization macrophages. 6. RNAseq induced gene sets macrophages predict poor patient outcome and correlate 7. Structural MSC-1 reveals...
<div>AbstractPurpose:<p>Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and thought to drive tumor development progression. Characterization of LIF clinical-stage inhibitors would increase our understanding as therapeutic target.</p>Experimental Design:<p>We first tested the association expression transcript signatures representing multiple processes regulating Next, we developed MSC-1, high-affinity antibody that...
<div>AbstractPurpose:<p>Leukemia inhibitory factor (LIF) is a multifunctional cytokine with numerous reported roles in cancer and thought to drive tumor development progression. Characterization of LIF clinical-stage inhibitors would increase our understanding as therapeutic target.</p>Experimental Design:<p>We first tested the association expression transcript signatures representing multiple processes regulating Next, we developed MSC-1, high-affinity antibody that...
<p>Supplementary Figure 1. Transcriptomic analysis demonstrates an enrichment of immunological pathways in high LIF tumors. Supplementary 2. transcripts are associated with a panel immunosuppressive macrophage/myeloid signatures across human tumor indications. 3. specifically suppressive macrophage 4. tend to be highly expressed aggressive 5. drives polarization macrophages. 6. RNAseq induced gene sets macrophages predict poor patient outcome and correlate 7. Structural MSC-1 reveals...