A5103209386- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Metallurgical Processes and Thermodynamics
- Synthesis and Biological Evaluation
- Particle Dynamics in Fluid Flows
- Algebraic Geometry and Number Theory
- Fluid Dynamics and Heat Transfer
- Polynomial and algebraic computation
- Commutative Algebra and Its Applications
- Soil and Water Nutrient Dynamics
- Soil Carbon and Nitrogen Dynamics
- Glycosylation and Glycoproteins Research
- Geometric and Algebraic Topology
- Advanced Differential Equations and Dynamical Systems
- Carbohydrate Chemistry and Synthesis
- Phosphorus and nutrient management
- Aerosol Filtration and Electrostatic Precipitation
- Agriculture, Soil, Plant Science
- Plant Molecular Biology Research
- Cassava research and cyanide
- Solidification and crystal growth phenomena
- Homotopy and Cohomology in Algebraic Topology
- Virology and Viral Diseases
- Geometric Analysis and Curvature Flows
- Peptidase Inhibition and Analysis
TU Bergakademie Freiberg
2016-2024
Kiel University
2024
Roche (Switzerland)
2017
CS Diagnostics
2013
Roche Pharma AG (Germany)
2013
University of Freiburg
2009-2010
We developed cergutuzumab amunaleukin (CEA-IL2v, RG7813), a novel monomeric CEA-targeted immunocytokine, that comprises single IL-2 variant (IL2v) moiety with abolished CD25 binding, fused to the C-terminus of high affinity, bivalent carcinoembryonic antigen (CEA)-specific antibody devoid Fc-mediated effector functions. Its molecular design aims (i) avoid preferential activation regulatory T-cells vs. immune cells by removing binding; (ii) increase therapeutic index therapy (a) retention at...
Effective nitrogen (N) management is essential for minimizing fertilizer nutrient losses and maximizing N use efficiency. This study, conducted over two years on permanent grassland sites in Schleswig-Holstein, Germany, explored the effects of urea treatment with a urease inhibitor digestate acidification N-cycling yield performance temperate maritime context. Micro plots within these grasslands received varying rates via acidified (with sulphuric acid) or non-acidified (biogas residues),...
Herein, the increase in cleanliness of steel melt is researched using an industrial‐scale prototypical tundish. State‐of‐the‐art alumina‐coated, carbon‐bonded ceramic foam hybrid filters are used, which combine different filtration strategies for removal nonmetallic inclusions (NMI) melts. Reactive cleaning reduces a high amount by means flotation because carbon monoxide bubbles. Their formation based on reaction between dissolved from filter and oxygen melt. The direct deposition NMI at...
The free falling liquid steel jet behavior is numerically investigated using implicit large eddy simulations (ILES) and the volume of fluid (VOF) approach. research focused on primary breakup phenomena near nozzle standard open‐source computational dynamics library OpenFOAM. To quantify influence process constructional parameters exclusively for structure a jet, several central conditions are explored. calculations concentrate disturbances at inlet due to adverse inflow conditions. caused by...
The SARS-CoV-2 pandemic has forced choirs to pause or at least restrict rehearsals and concerts. Nevertheless, an uncertainty about the risks of infection while singing remains, especially with regard distances, duration singing, number singers their positions in room, size room as well ventilation strategies. Based on assumption that CO
Abstract Introduction: IL-2 therapy can lead to durable responses in a modest proportion of cancer patients, but the treatment is associated with significant toxicity. Over last decades, various IL-2-based immunocytokines have been generated by fusing tumor-targeting antibodies. However, none these molecules progressed beyond Phase II trials and they are hampered liabilities: 1) High functional affinity (low pM) for IL-2Rabg on immune cells pulmonary vascular endothelium (Krieg et al., PNAS,...
Zariski chambers provide a natural decomposition of the big cone an algebraic surface into rational locally polyhedral subcones that are interesting from point view linear series. In present paper we algorithm allows to effectively determine when negative curves on known. We show how can be used compute number Del Pezzo surfaces.
In this short note we study foliations on surfaces with rationally connected leaves. Our main result is that a surface there exists polarisation such the Harder-Narasimhan filtration of tangent bundle respect to yields maximal quotient surface.
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
<p>Assessment of binding CEA TCB to human and cynomolgus monkey CEA- CD3-expressing cells, internalization ADCC, CDC activity.</p>
<p>Pharmacokinetic profiles of CEA TCB in mice, additional information on CD3 signaling, T cell activation, tumor lysis and cytokine release upon untargeted control treatment.</p>
<p>Detection of tumor targeting by in vivo imaging (fluorescent intensity, FLI)of CEA TCB formats having bivalent or monovalent binding to and directly labeled with Alexa647.</p>
<p>Correlation between CEA TCB response and genetic data</p>
<p>Pharmacokinetic profiles of CEA TCB in mice, additional information on CD3 signaling, T cell activation, tumor lysis and cytokine release upon untargeted control treatment.</p>
<p>Representative videos of intravital two-photon (2P) microscopy tumors treated with CEA TCB. Tumor cells red, T green.</p>