A5035290017- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Ocular Surface and Contact Lens
- Gastrointestinal motility and disorders
- Inflammatory mediators and NSAID effects
- Glaucoma and retinal disorders
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Biochemical and Structural Characterization
- Pesticide Residue Analysis and Safety
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Nonlinear Optical Materials Research
- Proteoglycans and glycosaminoglycans research
- Synthesis of β-Lactam Compounds
- Colorectal Cancer Treatments and Studies
- Nitric Oxide and Endothelin Effects
- Pharmaceutical Quality and Counterfeiting
- Antibiotics Pharmacokinetics and Efficacy
- Ocular Infections and Treatments
- Natural Antidiabetic Agents Studies
- Advancements in Transdermal Drug Delivery
Lupin Pharmaceuticals (India)
2011-2023
Birla Institute of Technology and Science, Pilani
2000-2011
Controlled release preparations have been reported to reduce the gastro irritant and ulcerogenic effects of non steroidal antiinflammatory drugs. In present study, an attempt was made develop matrix tablet-based controlled formulations ibuprofen, using ethyl cellulose as rate-controlling polymer. order prevent initial drug in acidic environment stomach, acetate phthalate incorporated varying amounts. It found that with increasing proportion matrix, extended for 14-16 h. Incorporation...
The purpose of the present study was to investigate effect incorporating pH-responsive polymers Eudragit (L100 or S100) in matrix bases composed hydrophilic polycarbophil and carbopol design oral controlled release formulations with sigmoidal profile for colon-specific delivery. Matrix tablets were prepared by wet granulation technique using indomethacin as model drug characterized physical parameters, vitro release, kinetics, stability on storage. gastrointestinal (GI) transit selected also...
The aim of this study was to design and develop microspheres indomethacin with pH transit time dependent release properties for achieving targeted delivery the colon. Microspheres containing varying proportions ethyl cellulose Eudragit (L100 or S100) either alone in combination were prepared using an oil-in-oil emulsion-based solvent evaporation technique. System comprising acetone (internal phase) liquid paraffin (external ratio 1 : 9 yielded good physical (spherical discrete), high drug...
Two simple and accurate ultraviolet (UV) spectrophotometric methods with better detection range for estimation of nimesulide in pure form solid dosage were developed the present studies using 50% v/v 100% acetonitrile as solvent system. The linearity both was found to be 10–50 μg/ml at a λmax 300 nm. linear regression equations obtained by least-square method are Abs = 1.33 × 10−1. Conc + 1.89 10−1 1.05 1.14 acetonitrile. limit per error propagation theory 0.46 1.04 μg/ml, respectively,...
In this study new, rapid and sensitive spectrofluorimetric methods for the quantitative estimation of celecoxib flurbiprofen in pure form their pharmaceutical dosage forms were developed. The solvent systems, wavelengths detection (excitation emission) optimized order to maximize sensitivity minimize cost analysis both drugs. No extraction procedure was employed these compounds formulation matrix, which reduced time sample preparation. excitation emission found be 256 nm 403 respectively...
The objective of this study was to develop controlled release matrix embedded formulations celecoxib (CCX) as candidate drug using hydroxy propyl methyl cellulose (HPMC) and ethyl (EC), either alone or in combination, optimization techniques like polynomial method composite design. This would enable development with predictable better characteristics lesser number trials. Controlled tablets CCX were prepared by wet granulation method. vitro rate studies carried out USP dissolution apparatus...
The primary objective of the study was to develop a pH and transit time controlled sigmoidal release polymeric matrix for colon-specific delivery indomethacin. Tablet matrices were prepared using combination hydrophilic polymers (polycarbophil or carbopol) having sensitive swelling properties with hydrophobic polymer ethyl cellulose. characterized physical in vitro kinetics. presence cellulose resulted drug pattern negligible very low initial phase (0-6 h) followed by 14-16 h. retardation...
The primary objective of the study was to develop a pH and transit time controlled sigmoidal release polymeric matrix for colon-specific delivery indomethacin. Tablet matrices were prepared using combination hydrophilic polymers (polycarbophil or carbopol) having pH-sensitive swelling properties with hydrophobic polymer ethyl cellulose. characterized physical in vitro kinetics. presence cellulose resulted drug pattern negligible-to-very low initial phase (0–6 h) followed by 14–16 h....
Abstract A new, simple, and rapid, sensitive reversed phase liquid chromatographic method was developed for the estimation of nimesulide in blood serum using a 60:40 mixture acetonitrile orthophosphoric acid (pH 3.0) as mobile at 230 nm. The other conditions were optimized to minimize interference from matrix same time provide sufficient sensitivity be adopted vivo studies oral formulations nimesulide. Acetonitrile used precipitate proteins during sample preparation. Detector response found...
Abstract New reversed-phase liquid chromatographic methods, with UV detection, were developed for the quantitative estimation of flurbiprofen in rabbit blood serum and aqueous humor. The mobile phase other conditions optimized to minimize interference from biological matrix at same time provide sufficient sensitivity method be adopted vivo studies ophthalmic formulations flurbiprofen. Acetonitrile was used precipitate proteins or humor during sample preparation. A methanol: acetonitrile:...