A5078721181- Radiopharmaceutical Chemistry and Applications
- HER2/EGFR in Cancer Research
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Mining Techniques and Economics
- Peptidase Inhibition and Analysis
- Origins and Evolution of Life
- Mineral Processing and Grinding
- Protein Structure and Dynamics
- Belt Conveyor Systems Engineering
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Photoreceptor and optogenetics research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Intramuscular injections and effects
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- Blood transfusion and management
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemoglobin structure and function
- Blood disorders and treatments
- Neonatal Health and Biochemistry
- Adipose Tissue and Metabolism
- Parasites and Host Interactions
Mersana Therapeutics (United States)
2018-2023
New York City College of Technology
2021
Virginia Tech
2010
McMaster University
1998-2007
Queen's University
2000-2007
Tufts University
2007
The University of Melbourne
2007
University of Alabama at Birmingham
2004-2005
University of South Australia
2005
University of Alabama
2003
Based on our previous observation that heparin-induced thrombocytopenia (HIT) sera can generate platelet microparticles from washed platelets in a heparin-dependent fashion, we developed test for HIT using flow-cytometry to measure microparticle formation. During the developmental phase of assay optimal physical conditions generation were defined. 133 then evaluated and serotonin release determine threshold defining positive result gave sensitivity specificity. The was prospectively against...
Antibody-drug conjugates (ADC) achieve targeted drug delivery to a tumor and have demonstrated clinical success in many types. The activity safety profile of an ADC depends on its construction: antibody, payload, linker, conjugation method, as well the number payload drugs per antibody [drug-to-antibody ratio (DAR)]. To allow for optimization given target antigen, we developed Dolasynthen (DS), novel platform based auristatin hydroxypropylamide, that enables precise DAR-ranging site-specific...
Abstract A 32‐residue α‐helical peptide with a sequence similiar to that of the GCN4 leucine zipper region is shown catalyze its own formation by accelerating amide bond 17‐residue peptide, preactivated as thiobenzyl ester, and 15‐residue N ‐terminal cysteine. The self‐replication process displays parabolic growth characteristics revealed detailed kinetic analysis. Control reactions single‐mutant peptides strongly support mechanism in which ternary and/or quaternary complex product both...
There is great interest in the structure of adiponectin as its oligomeric state may specify biological activities. It occurs a trimer, hexamer and high molecular weight complex. Epidemiological data indicate that form significant with low serum levels type 2 diabetics but to date, has not been well‐defined. To resolve this issue, characterization oligomer from bovine 3T3‐L1 adipocytes by sedimentation equilibrium centrifugation gel electrophoresis respectively, was carried out, revealing it...
Make a mistake (produce mutant peptide) and this simple nonlinear chemical network counteracts the error by upregulating reproduction of native sequence. The reacts to these spontaneously occurring errors subjugating peptides T9a T26a for catalyzing condensation peptide fragments E N produce replicator T. This mechanism dynamic correction could be significance stabilization genomic information.
Abstract: Engineers are increasingly expected to consider several influential criteria when selecting a single best management practice (BMP) for stormwater management. These include site physical characteristics; local, state, and federal pollution control ordinances; stakeholder input, BMP implementation long‐term maintenance costs. This paper discusses the development of software‐aided approach based on Analytic Hierarchy Process (AHP) as decision‐making tool BMPs. Supported with input...
A 33-residue de novo designed peptide ligase is reported which catalyzes the template-directed condensation of suitably activated short peptides with catalytic efficiencies in excess 105 ([kcat/Km]/kuncat). The peptide, derived from natural and α-helical coiled-coil proteins, presents a surface for substrate assembly via formation hydrophobic core at interface. Charged residues flanking provide additional binding specificity through electrostatic complementarity. Addition template to an...
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Abstract Key defining attributes of an antibody–drug conjugate (ADC) include the choice targeting antibody, linker, payload, and drug-to-antibody ratio (DAR). Historically, most ADC platforms have used same DAR for all targets, regardless target characteristics. However, recent studies modeling suggest that optimal can depend on expression level intratumoral heterogeneity, internalization trafficking, characteristics linker payload. An platform enables optimization could improve success rate...