A5062452095- Parkinson's Disease Mechanisms and Treatments
- Opioid Use Disorder Treatment
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Nerve injury and regeneration
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Renal Diseases and Glomerulopathies
- Substance Abuse Treatment and Outcomes
- Obesity, Physical Activity, Diet
- Restless Legs Syndrome Research
- Pharmaceutical Practices and Patient Outcomes
- Consumer Packaging Perceptions and Trends
- Bariatric Surgery and Outcomes
- Connective tissue disorders research
- Biochemical Analysis and Sensing Techniques
- Bacteriophages and microbial interactions
- Health disparities and outcomes
- Pulmonary Hypertension Research and Treatments
- Telomeres, Telomerase, and Senescence
- Lung Cancer Research Studies
- Mast cells and histamine
- Prenatal Substance Exposure Effects
- Dysphagia Assessment and Management
- Consumer Attitudes and Food Labeling
Xi'an Jiaotong University
2016-2025
Tongde Hospital of Zhejiang Province
2021-2025
Nanjing Medical University
2017-2024
Jiangsu Province Hospital
2019-2024
China Pharmaceutical University
2024
University of Kentucky
2021-2023
West China Hospital of Sichuan University
2022-2023
Sichuan University
2022-2023
Nanjing University of Chinese Medicine
2019
Wuhan University
2019
Increasing evidence suggests that patients with Parkinson's disease (PD) present peripheral autonomic dysfunction (AutD) even precedes motor deficits, through which α-synuclein can spread to the central nervous system. However, pathological mechanisms underlying AutD in prodromal PD remain unclear. Here, we investigated role of and its interplay activation Schwann cells (SCs) vagus nerve AutD.Rats were subjected injection adeno-associated viruses containing human mutated A53T gene (AAV-A53T)...
Abstract Despite the significant frequency of autonomic dysfunction (AutD) in Parkinson’s disease (PD) patients, its pathogenesis and diagnosis are challenging. Here, we aimed to further explore mechanism phosphorylated α-synuclein (p-α-syn) deposited vagus nerve Schwann cells (SCs) causing SCs damage PD AutD. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg) was administrated C57BL/6 mice twice a week for 35 days. Following final injection, locomotor functions, gastrointestinal...
To explore the extent and nature of television food advertising especially unhealthy to primary school children in Xi'an, China.Television data were recorded for 2 weekdays weekend days between 6:00 22:00 during May June 2012 from a total five channels most popular with Xi'an. Pearson χ (2) tests logistic regression applied determine differences proportion healthy food, miscellaneous advertisements different channels, programs, dates, viewing periods use persuasive marketing tactics.Of 5527...
Cardiac hypertrophy initially serves as an adaptive response to physiological and pathological stimuli. Sustained progress cardiac hypertrophy, fibrosis ultimately lead heart failure, one of the leading medical causes mortality worldwide. Intervention can effectively reduce occurrence failure. Abundant factors, such adrenergic, angiotensin, endothelin (ET-1) receptors, have been shown participate in regulation hypertrophy. Recently, increasing number studies indicated that circRNA...
Objective The process of glycolysis from blood collection to centrifugation impacts the diagnosis gestational diabetes mellitus (GDM). However, specific characteristics working environment in China and its influence on GDM still need be clarified.
ABSTRACT Maternal adiposity has been identified as a predictor of child overweight/obesity; however, it remains unclear whether the association changes ages. We aimed to examine associations between maternal weight status during pregnancy and offspring physical growth from birth early adolescence using data cohort study in rural western China. measurements first, second third trimesters were used calculate body mass index (BMI) gestational gain (GWG) rate, then classified following Institute...
Cardiac fibrosis is a pathological process underlying myocardial remodeling and characterized by excessive deposition of the extracellular matrix. Long noncoding RNAs (lncRNAs) have emerged as critical regulators various biological processes. In this study, we investigated role novel lncRNA, Gm41724, in cardiac induced pressure overload. High-throughput whole transcriptome sequencing analysis was performed to detect differentially expressed lncRNAs fibroblasts (CFs) with or without TGF-β1...
Sinomenine has been used to treat autoimmune diseases for centuries. However, little is known about its exact mechanisms of action. Whether sinomenine an effect on programmed death‑1 (PD‑1) ligands (PD‑Ls) in vivo remains unclear. The present study aimed determine the expression PD‑L1 and PD‑L2 peripheral blood mononuclear cells (PBMCs). A total 25 patients with mesangial proliferative nephritis (MsPGN) were treated followed up 3 months. was studied by using real‑time RT‑PCR flow cytometric...
// Jun Li 1, * , Shiwei Yang Zhening Pu 2, Juncheng Dai 2 Tao Jiang Fangzhi Du Zhu Yue Cheng Genyin 1 Wang Jirong Qi 3 Liming Cao Xueying Cong Ren Xinli 4 Yuming Qin Department of Cardiology, Children's Hospital Nanjing Medical University, 210008, China Epidemiology and Biostatistics, Jiangsu Key Lab Cancer Biomarkers, Prevention Treatment, Collaborative Innovation Center for Medicine, School Public Health, 211166, Cardiothoracic Surgery, The First Affiliated Hospital, 210029, These authors...
Long non‐coding RNAs (lncRNAs) participate in the development of breast cancer. Genetic variants lncRNAs may be involved their abnormal expressions and associated with cancer risk. In present study, we performed RNA sequencing on five paired tumor adjacent non‐cancerous tissues to obtain differentially expressed lncRNAs. We systematically selected potential regulatory these investigated associations between susceptibility 1486 cases 1519 cancer‐free controls a Chinese population. Eleven were...
BACKGROUND:The clinical association between gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) has been known for many years, but it is still unclear. The present study investigated the experimentally simulated aspiration fibrosis. MATERIAL AND METHODS:A total of 120 male Sprague-Dawley rats were randomly divided into a negative control group, bleomycin 3 groups. group was administered one-time intratracheal injection bleomycin, whereas groups treated either with...
Parental household wealth has been shown to be associated with offspring health conditions, while inconsistent associations were reported among generally healthy population especially in low- and middle- income countries (LMICs). Whether the upward mobility LMICs would confer benefits child remains unknown. We conducted a prospective birth cohort of children born mothers who participated randomized trial antenatal micronutrient supplementation rural western China. Household repeatedly...
Post-operative fatigue syndrome (POFS) is a common complication that prolongs the recovery to normal function and activity after surgery. The aim of present study was explore mechanism central in POFS anti-fatigue effect ginsenoside Rb1.We investigated association between inflammation, indoleamine 2,3-dioxygenase (IDO) enzyme, tryptophan metabolism hippocampus rats. A rat model induced by major small intestinal resection. Rats with resection were administered Rb1 (15 mg/kg) once day from 3...
Background Marfan syndrome (MFS) is an inherited connective tissue disorder affecting the ocular, skeletal and cardiovascular systems. Previous studies of MFS have demonstrated association between genetic defects clinical manifestations. Our purpose was to investigate role novel variants in determining phenotypes. Methods We sequenced whole exome 19 individuals derived from three Han Chinese families. The sequencing data were analyzed by a standard pipeline. Variants further filtered against...
Abstract Background Treatment recommendations for patients with neuroendocrine tumors (NETs) include the use of octreotide long-acting release (LAR) long-term therapy and immediate-release (IR) as rescue to control breakthrough symptoms carcinoid syndrome (CS). High doses LAR are commonly used in clinical practice. This study aimed evaluate real-world utilization preceding IR at prescription patient levels. Methods We an administrative claims database (2009-2018) containing privately insured...
Abstract Purpose The opioid crisis remains a major public health concern in the United States. Naloxone is used to reverse overdoses. This study examined Medicaid expansion on naloxone prescriptions retail pharmacies metropolitan (metro) and nonmetropolitan (nonmetro) areas (2011‐2017). Methods We population average models evaluate association of at state level number dispensed percentage paid by Medicaid, including adjustment for opioid‐related state‐level policy covariates....
To develop a local quality assurance program in cytopathology based on circulation of patient specimens glass slides, with limited resources.A working group was set up for design and running the program. Participation is laboratory basis. The scope frequency testing are defined. Well-documented cases (including gynecologic, nongynecologic fine needle aspiration cytology) commonly encountered diagnoses collected. Consensus concerning diagnosis, interpretive menu scoring system sought before...