A5101792180- Pharmacology and Obesity Treatment
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Dental Anxiety and Anesthesia Techniques
- Click Chemistry and Applications
- Anesthesia and Pain Management
- Enzyme Catalysis and Immobilization
- Peripheral Nerve Disorders
- Synthesis and biological activity
- Ionic liquids properties and applications
- Anesthesia and Sedative Agents
- Moringa oleifera research and applications
- Pregnancy-related medical research
- Natural Antidiabetic Agents Studies
- Pharmacogenetics and Drug Metabolism
- Bioactive Compounds and Antitumor Agents
- Chemistry and Chemical Engineering
- Nerve Injury and Rehabilitation
- Organ Donation and Transplantation
- Hip disorders and treatments
- Autophagy in Disease and Therapy
- Pediatric Pain Management Techniques
- Phytochemistry and Biological Activities
- Renal function and acid-base balance
- Orthopedic Surgery and Rehabilitation
Central Drug Research Institute
2013-2025
Academy of Scientific and Innovative Research
2025
Birla Institute of Technology and Science, Pilani
2020-2025
All India Institute of Medical Sciences Raipur
2025
All India Institute of Medical Sciences
2025
All India Institute of Medical Sciences Bhopal
2025
Adesh University
2020-2024
Amity University
2023-2024
Jai Prakash Vishwavidyalaya
2023
Parul University
2023
ABSTRACT A set of coumarin‐3‐carboxamide analogues were designed, synthesized, and evaluated for their ability to impede pancreatic lipase (PL) activity. Out all the analogues, 5dh 5de demonstrated promising inhibitory activity against PL, as indicated by respective IC 50 values 9.20 11.4 μM, compared Orlistat (IC = 0.97 μM). It was found that analogue inhibited PL in a competitive manner with an inhibition constant ( K i ) 4.504 μM. Additionally, docking analysis validated interactions...
A series of new 2,5-disubstituted arylidene derivatives thiazolidinedione (16a-e, 17a-d, 18a-c) designed using molecular hybridization approach were synthesized, structurally characterized, and explored for their anti-obesity potential via inhibition Pancreatic Lipase (PL). Compound 18a presented the most potent PL inhibitory activity with IC50 = 2.71 ± 0.31 µM, as compared to standard drug, Orlistat (IC50 0.99 µM). Kinetic study revealed reversible competitive mode enzyme by compound an...
Several new coumarin and chromene prototype derivatives have been synthesised evaluated for their ERα ERβ selective activity. Coumarin compounds 18 & 19 were found to be the most active, exhibiting potential antiproliferative activity against both ER +ve −ve breast cancer cell lines. The surprise finding of series, however, are novel III chromenes 45 46, with aroyl substitution at 6th position. Both shown potent lines, promote alkaline phosphatase activity, enhance osteoblast mineralization...
Abstract A series of 1,1′‐biphenyl‐3‐carboxamide and furan‐phenyl‐carboxamide analogs were synthesized using an optimized scheme confirmed by 1 H 13 C nuclear magnetic resonance high‐resolution mass spectrometry techniques. The peptidomimetics screened in vitro to understand the inhibitory potential pancreatic lipase (PL). Analogs assessed for PL activity based on interactions, geometric complementarity, docking score. Among analogs, 9 , 29 24 found have most potent with IC 50 values 3.87,...
WHO holding the hands of scientific commune and trying to repurpose drugs against SARS-CoV-2. The robust data has illustrated probable mechanistic path SARS-CoV-2 entry action in damaging cells. Which further demonstrated Hydroxychloroquine (HCQ; antimalarial drug) as promising drug therapeutic; apart from certain setbacks be an excellent agent treating COVID-19. In present study, we have explored derivatives HCQ, conjugated with bioactive agents by virtue sustainably modified clicked...
A series of novel indole-thiazolidinedione hybrid analogues (7a to 7 u) were synthesised, characterised and evaluated for their potential Pancreatic Lipase (PL) inhibition. Amongst the screened analogues, 7r was found be most active PL inhibitor with an IC50 2.67 µM. Furthermore, enzyme inhibition kinetics study revealed a competitive mode by analogues. This fact confirmed via fluorescence spectroscopy which further suggested presence one binding site synthesized Molecular docking performed...
Aim: To study the Central Macular Thickness (CMT) and Retinal nerve fiber layer (RNFL) thickness (RNFLT) using Optical Coherence Tomography (OCT) in cases of amblyopia. Methods Material: The was conducted on 30 patients unilateral amblyopia having vision less than 6/12 (30 amblyopic eyes fellow eyes) age matched normal controls aged between 5-30 years. Vision, Refraction ophthalmological examination done. OCT changes macula RNFL were evaluated both each patient controls. data statistically...
Abstract Owing to its ability induce cellular senescence, inhibit PCNA, and arrest cell division cycle by negatively regulating CDKs as well being a primary target of p53, p21 is traditionally considered tumor suppressor. Nonetheless, several reports in recent years demonstrated pro-oncogenic activities such apoptosis inhibition cytosolic p21, stimulation motility, promoting assembly cyclin D-CDK4/6 complex. These opposing effects on proliferation, supported the observations inconsistent...
Methanol and hexane extracts of leaves Moringa oleifera aerial parts Alternanthera sessilis were screened for the presence different classes phytoconstituents. Phytochemical screening revealed alkaloids, flavonoids, carbohydrates, terpenoids, polyphenols, glycosides, coumarins in methanol extracts. Volatile oils, quinines, phytosterols absent all saponins present The biological activity was tested by performing brine shrimp bioassay. All except extract found to be cytotoxic against nauplii....
Background The carpal tunnel is a groove that spans the palm as 'U.' ulnar and radial sides of wrist are made up scaphoid tubercle trapezium while palmar aspect bones. Our study aimed to see whether there were differences in size between men women. Material methods was conducted on 65 healthy adults, 13 (20%) males 52 (80%) females (both non-pregnant pregnant). Inclusion criteria adults bilaterally symmetrical limbs. Exclusion chronic disease, diabetes, hypertension, immunological disorders,...
Obesity is a multifactorial metabolic disorder, growing in an alarming rate across the world. Amongst numerous targets explored for obesity management, inhibition of pancreatic lipase (PL) considered as one promising approaches. Orlistat only PL inhibitory drug approved long term treatment obesity. However, it reported to possess hepatotoxicity and nephrotoxicity. Thus, novel candidates that act through are hour's need. Based on this aim, series quinazolinone hybrid analogues have been...
It has been seen that very less attention given to the oral health of geriatric population residing in old age homes and as mucosal lesions are a matter concern for this growing population. Therefore, study was done with objective finding prevalence distribution among 65-74 year residents Delhi, India.A cross sectional on group elders Delhi. A total 464 subjects participated study. Oral Health Assessment Form, WHO used assessing mucosa. Clinical examination performed using two mouth mirrors...
Trans–5–hydroxypipecolic acid has been identified by NMR of 13C in the leaves Xylia xylocarpa. This iminoacid is a powerful inhibitor platelet aggregation induced serotonin and thus, it probably involved biological effects plant extracts.
Background: An appropriate scale to assess the dental anxiety of Hindi speaking population is lacking. This study, therefore, aims evaluate psychometric properties version one oldest scale, Corah's Dental Anxiety Scale (CDAS) in Indian adults. Methods: A total 348 subjects from outpatient department a hospital India participated this cross-sectional study. The was cross-culturally adapted by forward and backward translation, committee review pretesting method. construct validity translated...
Introduction: Tracheal anatomy is useful for clinicians to select correct size of endotracheal tube. The study can be done by both invasive and non-invasive techniques like cadaveric dissection(CD), Computed Tomography (CT) scan. In present we measured diameter, length, cross sectional area, volume human trachea on CT scan images the data was compared with that other studies. Method: this prospective normal chest 110 cases (69 males 41 females) were studied. Chest scans performed 64 slice...