A5082708421- Dialysis and Renal Disease Management
- Physiological and biochemical adaptations
- Turtle Biology and Conservation
- Antimicrobial Peptides and Activities
- Insect and Pesticide Research
- Crystallization and Solubility Studies
- Insect and Arachnid Ecology and Behavior
- Organic Light-Emitting Diodes Research
- Lung Cancer Research Studies
- Organic Electronics and Photovoltaics
- Bird parasitology and diseases
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Chalcogenide Semiconductor Thin Films
- Blood transfusion and management
- Radioactive element chemistry and processing
- BRCA gene mutations in cancer
- Calcium Carbonate Crystallization and Inhibition
- Geological and Geochemical Analysis
- Blood donation and transfusion practices
- Insect Resistance and Genetics
- RNA modifications and cancer
- Molecular Junctions and Nanostructures
- Chemical Synthesis and Characterization
The University of Tokyo
2018-2025
Keio University
2021-2025
Tohoku University
2024
Tokyo Women's Medical University
2014-2024
Saku Central Hospital
2023
Hyogo Medical University
2021
University Kebangsaan Malaysia Medical Centre
2021
Kindai University
2017-2020
Kyushu Dental University
2018
Yamagata University
2015-2017
Modified uridine containing taurine, 5-taurinomethyluridine (τm5U), is found at the anticodon first position of mitochondrial (mt-)transfer RNAs (tRNAs). Previously, we reported that τm5U absent in mt-tRNAs with pathogenic mutations associated diseases. However, biogenesis and physiological role remained elusive. Here, elucidated by confirming 5,10-methylene-tetrahydrofolate taurine are metabolic substrates for formation catalyzed MTO1 GTPBP3. GTPBP3-knockout cells exhibited respiratory...
Singlet fission of thienoquinoid compounds in organic photovoltaics is demonstrated. The escalation the length realizes a suitable packing structure and energy levels for singlet fission. magnetic-field dependence photocurrent external quantum efficiency devices reveal dissociation triplet excitons into charges.
Abstract Background Companion diagnostic tests play a crucial role in guiding treatment decisions for patients with non‐small cell lung cancer (NSCLC). The Oncomine Dx Target Test (ODxTT) Multi‐CDx System has emerged as prominent companion method. However, its efficacy detecting driver gene mutations, particularly rare warrants investigation. Aims This study aimed to assess the performance of ODxTT mutations NSCLC patients. Specifically, we evaluate sensitivity epidermal growth factor...
Calcite is a ubiquitous mineral in nature. Heavy alkaline-earth elements with large ionic radii such as Sr2+ and Ba2+ are highly incompatible to calcite. Our previous study clarified that ions can be structurally incorporated into calcite through crystallization from amorphous calcium carbonate (ACC). In this study, we synthesized Sr-doped Sr/(Sr + Ca) up 30.7 ± 0.6 mol% Ba-doped Ba/(Ba 68.6 1.8 mol%. The obtained samples Ba concentration higher than Ca interpreted Ca-containing barium...
Measuring the heart rate of sea turtles is important for understanding their physiological adaptations to environment. Non-invasive methods measure electrocardiogram (ECG) have been developed by attaching electrodes carapace. However, this method has only applicable with sparse keratin on shell surfaces, such as loggerhead turtles, and it difficult detect heartbeats in dense keratinous scutes, including green turtles. Here, we explored electrode placements plastron that can be applied ECG...
Although EGFR tyrosine kinase inhibitors (EGFR-TKIs) are effective for EGFR-mutant lung adenocarcinoma (LUAD), resistance inevitably develops through diverse mechanisms, including secondary genetic mutations, amplifications and as-yet undefined processes. To comprehensively unravel the mechanisms of EGFR-TKI resistance, we establish a biobank patient-derived cancer organoids, encompassing cases previously treated with EGFR-TKIs. Through comprehensive molecular profiling single-cell analysis,...
Presumed germline pathogenic variants (PGPVs) are occasionally detected in thoracic cancer and their frequency functional significance remain underexplored. We investigated the prevalence biological of PGPVs identified comprehensive genomic profiling (CGP) panels patients with cancer. Between January 2021 August 2023, 204 were included this study. A somatic profile system-FoundationOne CDx or an in-house system (Rapid-Neo)-was used for next-generation sequencing-based gene panel tests....
9,9′-Bifluorenylidene (BFN) derivatives, in which the two fluorene moieties are connected <italic>via</italic> a CC double bond at 9-position, expected to show singlet fission (SF) character organic photovoltaics (OPVs).
ABSTRACT Air-breathing vertebrates exhibit cardiovascular responses to diving including heart rate reduction (diving bradycardia). Field studies on aquatic mammals and birds have shown that the intensity of bradycardia can vary depending behaviour, such as depth dives dive duration. However, in reptiles, variation during deep under natural conditions has not been fully investigated. In this study, we released five loggerhead sea turtles (Caretta caretta) outfitted with recorders into...
The quick sequential organ failure assessment (qSOFA) was widely used to estimate the risks of sepsis in patients with suspected infection prehospital and emergency department (ED) settings. Due insufficient sensitivity qSOFA on arrival at ED (ED qSOFA), Surviving Sepsis Campaign 2021 recommended against using as a single screening tool for sepsis. However, it remains unclear whether combined use improves its identifying higher risk ED.We retrospectively analyzed data from tertiary medical...
A highly sensitive method is proposed for obtaining the Raman spectra of low-concentration proteins and nucleic acids in an aqueous solution using liquid–liquid phase separation.
Donor-type and acceptor-type 9,9′-bifluorenylidene derivatives, MOBF CNBF, were synthesized. Suitable energy levels on the excited states of compounds for singlet fission revealed by density functional theory calculation. Thermal optoelectronic properties investigated, OPV devices with donor-type CNBF fabricated. showed large dependence photocurrent magnetic field, suggesting behavior in device. On other hand, did not show any field photocurrent, probably because poor morphology.
Uncertainty for elemental and isotopic measurements in calcite by LA‐ICP‐MS is largely controlled the homogeneity of reference materials (RMs) used calibration validation. In order to produce RMs with homogeneous compositions, we incorporated elements including U, Pb rare earth into through heat‐ pressure‐induced crystallisation from amorphous calcium carbonate that was precipitated element‐doped reagent solution. X‐ray absorption spectra showed U present as U(VI) synthesised calcite,...
Heart rate measurement is an essential method for evaluating the physiological status of air-breathing diving animals. However, owing to technical difficulties, many marine animals require invasive approach record electrocardiogram (ECG) in water, limiting application this a wide range Recently, non-invasive system was reported measure ECG hard-shelled sea turtles by pasting electrodes on dorsal side shell, although obtained from moving turtle contains noise produced muscle contraction....
Diving bradycardia is a reduction in the heart rate mediated by parasympathetic system during diving. Although diving pronounced aquatic mammals and birds, existence of this response reptiles, including sea turtles, remains under debate. Using blocker atropine, we evaluated involvement nervous loggerhead turtles (Caretta caretta) voluntary tanks. The control group dropped 40-60% from pre-dive value at onset diving; however, administration atropine significantly inhibited (P<0.001). Our...
Background: Left ventricular hypertrophy (LVH) is a common cardiovascular complication and an independent risk factor for death in hemodialysis (HD) patients. Previous studies have shown that fibroblast growth 23 (FGF23), which has important role phosphate metabolism, elevated HD Objectives: The aim of this study was to determine the association FGF23 LVH prognostic value serum level One hundred seven patients were evaluated by echocardiography. Serum levels measured using commercial...
ABSTRACT Heart rates of air-breathing diving animals can change on a short time scale due to the response during submergence. rate is used frequently as proxy for indirectly estimating metabolic fine scale. However, most studies date have been conducted endothermic animals, and relationships between heart in ectothermic not well studied. Sea turtles are unique model organisms ectotherms because they spend their life ocean perform deep and/or long dives. In this study, we examined...