A5028693815- Genetics, Aging, and Longevity in Model Organisms
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Calcium signaling and nucleotide metabolism
- Cervical Cancer and HPV Research
- RNA regulation and disease
- Virus-based gene therapy research
- Telomeres, Telomerase, and Senescence
- Immune responses and vaccinations
- Herpesvirus Infections and Treatments
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
- Frailty in Older Adults
- Endoplasmic Reticulum Stress and Disease
- Animal Virus Infections Studies
- Phagocytosis and Immune Regulation
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Ion Channels and Receptors
- Heat shock proteins research
- Sleep and related disorders
Buck Institute for Research on Aging
2006-2024
UCSF Helen Diller Family Comprehensive Cancer Center
2003
University of California, San Francisco
2003
Regenerative therapies are limited by unfavorable environments in aging and diseased tissues. A promising strategy to improve success is balance inflammatory anti-inflammatory signals enhance endogenous tissue repair mechanisms. Here, we identified a conserved immune modulatory mechanism that governs the interaction between damaged retinal cells promote repair. In retina of flies mice, platelet-derived growth factor (PDGF)-like signaling induced mesencephalic astrocyte-derived neurotrophic...
Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic relative (epigenetic acceleration) connected aging-associated pathologies, and changes linked canonical aging hallmarks. However, rely training data from bulk tissues whose cellular composition with Here, we found human naive CD8+ T cells, which decrease frequency during aging, exhibit an 15–20 years younger...
Evidence suggests that neuronal dysfunction in Huntington's disease (HD) striatum involves deficits mitochondrial function and Ca 2+ handling. However, the relationship between mitochondria handling has been incompletely studied intact HD striatal cells. Treatment with histone deacetylase (HDAC) inhibitors reduces cell death models, but effects of this promising therapy on cellular are mostly unknown. Here, we use real-time functional imaging intracellular membrane potential to explore role...
The mitochondrial unfolded protein response (UPRmt) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental stress activates UPRmt reporters and extends lifespan. We show that similar is necessary sufficient to extend Drosophila lifespan, identify Phosphoglycerate Mutase 5 (PGAM5) as a mediator of this response. Developmental leads activation FoxO, via Apoptosis Signal-regulating Kinase 1 (ASK1) Jun-N-terminal (JNK). This persists into adulthood...
Abstract Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic relative (epigenetic acceleration) connected aging-associated pathologies, and changes linked canonical aging hallmarks. However, rely training data from bulk tissues whose cellular composition with We found human naive CD8 + T cells, which decrease during aging, exhibit an 15–20 years younger than...
Abstract The decline in early life mortality since the 1950s has resulted dramatic demographic shift towards aged population. Aging manifests as a health, multiple organ dysfunction and increased vulnerability to diseases, which degrades quality of life. A verity genetic pharmacological interventions, mostly from non-vertebrate models, have been identified that can enhance lifespan. Whether these interventions extend healthspan, disease free functional period life, only sometimes tested is...
<title>Abstract</title> Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG methylation values to predict chronological or biological age. Increases in predicted epigenetic relative (epigenetic acceleration) connected aging-associated pathologies, and changes linked canonical aging hallmarks. However, rely training data from bulk tissues whose cellular composition with We found human naive CD8<sup>+</sup> T cells, which decrease during aging, exhibit an...
Summary Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of are unclear. Here, we show that CD38, consuming enzyme, expressed extrafollicular space, primarily immune cells, its levels increase age. Reproductively young mice lacking CD38 exhibit larger primordial follicle pools, elevated levels, increased fecundity relative to wild type controls....
Abstract Gene drives are genetic modifications designed to propagate efficiently through a population. Most applications rely on homologous recombination during sexual reproduction in diploid organisms such as insects, but we recently developed gene drive herpesviruses that relies co-infection of cells by wild-type and engineered viruses. Here, viral against human herpes simplex virus 1 (HSV-1) showed it propagated vitro HSV-1 infection mice. We observed high levels drive-mediated neuronal...
Abstract The post-translational modification, lysine succinylation is implicated in the regulation of various metabolic pathways. However, its biological relevance remains uncertain due to methodological difficulties determining high-impact sites. In present study, using stable isotope labeling and data-independent acquisition mass spectrometry, we quantified stoichiometries mouse livers. Despite low overall stoichiometry succinylation, several high sites were identified, especially upon...