A5079602501- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Adrenal Hormones and Disorders
- Epilepsy research and treatment
- Cerebrospinal fluid and hydrocephalus
- Vestibular and auditory disorders
- Intracranial Aneurysms: Treatment and Complications
- Neurological disorders and treatments
- Diet and metabolism studies
- Stress Responses and Cortisol
- Infectious Diseases and Tuberculosis
- Animal testing and alternatives
- Thermoregulation and physiological responses
- IgG4-Related and Inflammatory Diseases
- Diverticular Disease and Complications
- Growth Hormone and Insulin-like Growth Factors
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmacological Effects and Toxicity Studies
- Genetic Neurodegenerative Diseases
- Sleep and Wakefulness Research
- Heart Rate Variability and Autonomic Control
- Metabolism and Genetic Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
Cornell University
2014-2024
Presbyterian Hospital
2016-2024
NewYork–Presbyterian Hospital
2014-2024
New York Hospital Queens
2016-2024
American Academy of Neurology
2022
Penn Presbyterian Medical Center
2022
Weill Cornell Medicine
2018-2021
Ovid Therapeutics (United States)
2021
Rockefeller University
2013-2020
MIND Research Institute
2014-2020
Standard clinical characterization of patients with disorders consciousness (DOC) relies on observation motor output and may therefore lead to the misdiagnosis vegetative state or minimally conscious in preserved cognition. We used conventional electroencephalographic (EEG) measures assess a cohort DOC without functional magnetic resonance imaging (fMRI)-based evidence command-following, correlated findings standard behavioral evaluation brain metabolic activity.We enrolled 44 severe injury....
See Boly and Laureys (doi:10.1093/brain/awy080) for a scientific commentary on this article.Patients with severe brain injury are difficult to assess frequently subject misdiagnosis. 'Cognitive motor dissociation' is term used describe subset of such patients preserved cognition as detected neuroimaging methods but not evident in behavioural assessments. Unlike the locked-in state, cognitive dissociation after prominently marked by concomitant injuries across cerebrum addition limited or no...
Recognition of potential for neurological recovery in patients who remain comatose after cardiac arrest is challenging and strains clinical decision making. Here, we utilize an approach that based on physiological principles underlying consciousness show correlation with acute anoxic brain injury.A cohort study 54 admitted to Intensive Care Unit underwent standardized bedside behavioral testing (Coma Recovery Scale - Revised [CRS-R]) during EEG monitoring. Blinded all variables,...
We reviewed the records of 70 consecutive adult patients with meningitis after a neurosurgical procedure, to determine characteristics that might help distinguish sterile postoperative chemical from bacterial infection. The spinal fluid profiles in and are similar. exceptions white blood cell count > 7500/microL (7500 x 10(6)/L) glucose level < 10 mg/dL were not found any case meningitis. clinical setting manifestations distinct enough no antibiotic was administered lumbar puncture 30 (43%)...
FORGACSwas normally placed and extremely dilated with immense thickening of the myocardium endocardium" but relationship great veins to atria or ventricles main arteries is not described.Generally in these cases there are complicated defects an accurate diagnosis notoriously difficult.Our attempt discover a common pattern has succeeded only partially they can be divided into two groups.In first superior vena cava venous atrium follow abdominal viscera transposed, which obviously leads...
Objective Survivors of prolonged (>2 weeks) post–cardiac arrest (CA) coma are expected to remain permanently disabled. We aimed investigate 3 outlier patients who ultimately achieved independent functional outcomes after post‐CA identify electroencephalographic (EEG) markers their recovery potential. For validation purposes, we also evaluate these in an cohort patients. Methods identified with late from (17–37 days) following CA recovered functionally behavioral levels. performed spectral...
The two cases reported illustrate an uncommon type of partial inversion the viscera, in which abdominal organs alone are transposed while heart remains its normal position.Both were suffering from congenital disease, and a subsequent search brought to light several further reports cardiac malformation associated with similar transposition viscera.This combination cannot, therefore, be regarded as fortuitous, and, fact, well-recognized relationship exists between disease another variety...
Phoma minutella, a dematiaceous hyphomycete, was isolated to the exclusion of all other fungi from subcutaneous inflammatory process on foot farmer undergoing corticosteroid therapy for myasthenia gravis. Isolation achieved several nutrient media. Examination stained smears and sections revealed fungal elements consistent with mold. This is first reported association P. minutella human infection only second case involving sp. as etiologic agent infection.
Loss of organized sleep electrophysiology is a characteristic finding following severe brain injury. The return structured elements architecture has been associated with positive prognosis across injury etiologies, suggesting role for dynamics as biomarkers wakeful neuronal circuit function. In continuing study one minimally conscious state patient studied over the course approximately 8½ years, we sought to investigate whether changes in daytime activation induced by central thalamic deep...
To assess the potential biologic significance of variations in burst-suppression patterns (BSPs) after cardiac arrest relation to recovery consciousness. In context recent theoretical models BSP, bursting frequency may be representative underlying network dynamics; discontinuous activation membrane during impaired cellular energetics promote neuronal rescue.We reviewed a database 73 comatose post-cardiac patients who underwent therapeutic hypothermia for presence BSP and clinical outcomes....
Here, we present the first description of an isolation syndrome in a patient who suffered prolonged cardiac arrest and underwent standard therapeutic hypothermia protocol. Two years after arrest, demonstrated no motor responses to commands, communication capabilities or visual tracking at bedside. However, resting neuronal metabolism electrical activity across entire anterior forebrain was found be normal despite severe structural injuries primary motor, parietal occipital cortices. In...
Purpose: To investigate the effects of ketamine on patients with refractory status epilepticus after cardiac arrest. Methods: In this retrospective cohort, selected EEG segments from arrest were classified into different patterns (based background continuity and burden epileptiform discharges) spectral profiles presence frequency components). For who received ketamine, data compared before, during, infusion; for no-ketamine group, at three separated time points during recording. Ketamine...
Our objective was to determine perisaccadic gamma range oscillations in the EEG during voluntary saccades humans. We evaluated occipital activity both presence and absence of visual input, when observer blindfolded. quantified power time periods before, during, after horizontal saccades. The corresponding for individual wavelet transformed averaged each window, without averaging first. found that, dark light, parietal increased saccade peaked prior reaching new fixation. show that this is...
Journal Article A Case of Ureaplasma urealyticum Septic Arthritis in a Patient with Hypogammaglobulinemia Get access Pierre Forgacs, Forgacs From the Section Infectious Diseases and Departments Orthopedic Surgery Anatomic Pathology, Lahey Clinic Medical Center, Burlington; Epidemiology Medicine, Brigham Women's Hospital, Boston, Massachusetts Reprints or correspondence: Dr. Diseases, 41 Mall Road, Burlington, 01805. Search for other works by this author on: Oxford Academic PubMed Google...
To characterize the efficacy and safety of soticlestat (TAK-935/OV935) in children with Dravet syndrome (DS) Lennox-Gastaut (LGS) ELEKTRA study (NCT03650452).
Abstract Effective treatment options for patients with life-threatening neurological disorders are limited. To address this unmet need, high-impact translational research is essential the advancement and development of novel therapeutic approaches in neurocritical care. “The Neurotherapeutics Symposium 2019—Neurological Emergencies” conference, held Rochester, New York, June 2019, was designed to accelerate translation care via transdisciplinary team science diversity enhancement. Diversity...
Most preparations of corticotrophin (ACTH) contain melanophore expanding hormone (MEH) in proportion to their ACTH activity (Sprague et al., 1950, Johnsson 1952, Sulman, 1952). These two activities are also demonstrable any part the hypophysis, this being a result close functional interrelationship between lobes gland. However, whilst most is produced by anterior, MEH posterior and intermediate (Miahle-Voloss, 1953, Reinhardt In presence pituitary hyperfunction, level both increases, blood...
A routine aerobic culture of purulent material from a draining sinus tract patient with chronic lymphadenitis yielded growth fastidious gram-negative coccobacillus later identified as Brucella suis biotype 1. The responded to administration antibacterial drugs and surgical drainage.