A5109415540- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Chronic Disease Management Strategies
- Medication Adherence and Compliance
- Nerve injury and regeneration
- Health Systems, Economic Evaluations, Quality of Life
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Syncope and Autonomic Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Practices and Rehabilitation
- Cardiovascular Function and Risk Factors
- Autism Spectrum Disorder Research
- Health and Medical Studies
- Obsessive-Compulsive Spectrum Disorders
- Asthma and respiratory diseases
- Neurogenesis and neuroplasticity mechanisms
- Nursing care and research
- Potassium and Related Disorders
- Occupational exposure and asthma
- Cardiac Health and Mental Health
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Adolescent and Pediatric Healthcare
- Cellular transport and secretion
Max Planck Institute for Medical Research
2023
Santhera Pharmaceuticals (Switzerland)
2018
Novartis (Switzerland)
2013-2017
Novartis Institutes for BioMedical Research
2013-2016
Cornell University
2008-2011
Instituto Gulbenkian de Ciência
2010-2011
Institut Pasteur de Lille
2008
Centre National de la Recherche Scientifique
2008
Neurogenesis, the division, migration, and differentiation of new neurons, occurs throughout life. Brain derived neurotrophic factor (BDNF) has been identified as a potential signaling molecule regulating neurogenesis in subventricular zone (SVZ), but its functional consequences vivo have not well defined. We report marked unexpected deficits survival proliferation newly born cells adult knock-in mice containing variant form BDNF [a valine (Val) to methionine (Met) substitution at position...
SH3 and multiple ankyrin repeat domains 3 (SHANK3) haploinsufficiency is causative for the neurological features of Phelan-McDermid syndrome (PMDS), including a high risk autism spectrum disorder (ASD). We used unbiased, quantitative proteomics to identify changes in phosphoproteome Shank3-deficient neurons. Down-regulation protein kinase B (PKB/Akt)-mammalian target rapamycin complex 1 (mTORC1) signaling resulted from enhanced phosphorylation activation serine/threonine phosphatase 2A...
Stone et al. previously reported an association between the TBC1D1 gene variant R125W (rs35859249) and severe obesity in women from US pedigrees. We attempted to replicate this result 9714 French Caucasian individuals, combining family-based general population studies. confirmed with familial (defined as body mass index (BMI) ≥ 97th percentile) 1109 obesity-selected pedigrees (Z-score = 2.70, P 0.008). Analysis of 16 microsatellite markers on chromosome 4 restricted 42 carrying allele also...
Abstract Neurotrophins are a family of growth factors playing key roles in the survival, development, and function neurons. The neurotrophins brain‐derived neurotrophic factor ( BDNF ) NT 4 both bind to activate TrkB receptors, however, they mediate distinct neuronal functions. molecular mechanism how activation by leads diverse outcomes is unknown. Here, we report that lead differential endocytic sorting receptors resulting biological functions cultured cortical Fluorescent microscopy...
Purpose: Family and friends play a pivotal role in caring for patients with heart failure (HF); however, evidence of the impact caregiving is limited. The objectives this study were to describe burden on informal caregivers chronic HF China. Materials methods: A cross-sectional survey cardiologists, their HF, those patients’ was conducted. Patient record forms completed by 150 cardiologists 10 consecutive patients. Caregivers these invited complete questionnaire. Results: Overall, 458...
The accumulation of aggregated mutant huntingtin (mHtt) inclusion bodies is involved in Huntigton's disease (HD) progression. Medium sized-spiny neurons (MSNs) the corpus striatum are highly vulnerable to mHtt aggregate and degeneration, but mechanisms pathways remain elusive. Here we have developed a new model study MSNs degeneration context HD. We produced organotypic cortico-striatal slice cultures (CStS) from HD transgenic mice mimicking specific features then show that induction...
Purpose: Little evidence exists on the burden that chronic heart failure (HF) poses specifically to patients in China. The objective of this study, therefore, was describe HF Materials and methods: A cross-sectional survey cardiologists their with conducted. Patient record forms were completed by 150 for 10 consecutive patients. Patients whom a patient form invited complete questionnaire. Results: Most 933 (mean [SD] age 65.8 [10.2] years; 55% male; 80% retired) included study received care...
Objectives: This study aimed to provide early insights into sacubitril/valsartan (sac/val) prescription patterns and the demographic clinical characteristics of patients prescribed sac/val in primary care cardiology settings Germany.Methods: The used electronic medical records from German IMS® Disease Analyzer database. Patients with ≥1 for during 1 January–31 December 2016 (n = 1643) were identified followed up ≤12 months first prescription. heart failure (HF) diagnosis period, additional...
Purpose: Explore the extent to which heart failure (HF) symptoms and side effects of HF treatment experienced by patients are recognized cardiologists, concordance between patient–cardiologist perceptions severity patients' contributions decision-making. Methods: A multinational, cross-sectional survey cardiologists with was conducted. Patient-record forms (PRFs) were completed for consecutive consulting HF, who a patient self-completion questionnaire (PSC). Responses from PRFs an associated...
Pharmacological studies established a role for AMPARs in the mammalian forebrain spatial memory performance. Here we generated global GluA1/3 double knockout mice (
The objective of this study was to describe the clinical care pathways, management and treatment patterns, hospitalizations for patients with heart failure (HF) in China.A cross-sectional survey cardiologists their HF conducted. Patient record forms were completed by 150 10 consecutive patients. Patients whom a patient form invited complete self-completion questionnaire.Most 1,500 (mean [SD] age 66 [10] years; 55% male) included received tier-2 -3 hospitals large cities. Cardiologists...
The real-world characteristics of Pulmonary Hypertension with Lung Disease and/or Hypoxia (PH-LD) and PH Interstitial (PH-ILD) remain largely unknown. This study's objective is to characterize the epidemiology, treatment patterns, burden PH-LD PH-ILD, patterns Arterial (PAH). Retrospective longitudinal cohort study using claims data from France (PMSI, SNDS), Germany (SHI Funds), electronic medical records (EMR) UK (CPRD/HES) Jan-2015 Dec-2021. Two algorithms identify patients PAH were...
Pulmonary Hypertension with Lung Disease and/or Hypoxia (PH-LD) and PH interstitial lung disease (PH-ILD) are life-threatening diseases a high burden. We aimed to estimate the clinical economic burden of PH-LD PH-ILD sub-group using French hospital claims data (PMSI). This retrospective cohort study was conducted between 2015-21. Incident patients minimum 3-month follow-up were selected. All visits (inpatient or outpatient) analyzed during follow-up. The evaluated from healthcare system...
The epidemiology of Pulmonary Hypertension with Lung Disease and/or Hypoxia (PH-LD), including PH Interstitial (PH-ILD), remains unclear in France. This retrospective longitudinal study aims to characterize the prevalence and incidence PH-LD/ILD from French hospital claims database (PMSI). In absence ICD-10 codes identify PH-LD sub-group PH-ILD patients, an algorithm was adapted input six European experts. Patients recorded Jan 2017-Dec 2019, LD up 24 months prior or 60 days after index date...