A5091885017- Protein Structure and Dynamics
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Advanced Chemical Sensor Technologies
- Metabolism, Diabetes, and Cancer
- Olfactory and Sensory Function Studies
- Enzyme Structure and Function
- NF-κB Signaling Pathways
- Chemical Synthesis and Analysis
- Diabetes Treatment and Management
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Hippo pathway signaling and YAP/TAZ
- Angiogenesis and VEGF in Cancer
- Protein Kinase Regulation and GTPase Signaling
- Nitric Oxide and Endothelin Effects
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Studies on Chitinases and Chitosanases
- Neurobiology and Insect Physiology Research
- Bacteriophages and microbial interactions
- Eicosanoids and Hypertension Pharmacology
- Biochemical and Structural Characterization
- Aldose Reductase and Taurine
Harbin Medical University
2025
Fourth Affiliated Hospital of Harbin Medical University
2025
Anhui Medical University
2013-2020
Xiangya Hospital Central South University
2020
Central South University
2020
Changhai Hospital
2019
Second Military Medical University
2019
University of Kentucky
2011-2015
Sun Yat-sen University
2010-2013
University of South Carolina
2013
Inflammatory mediators, many of which activate the signaling nuclear factor kappa B (NFκB), have received increasing attention in field neurogenesis. NFκB regulates neurite outgrowth and neural plasticity as well proliferation/apoptosis terminal differentiation stem cells (NSCs). Early neurogenesis from NSCs produces identical progeny through symmetric division committed daughter asymmetric division. Here, we show that is required for NSC initial differentiation. The canonical IKKβ/IκBα/p65...
Background In order to identify novel chemical classes of β-secretase (BACE-1) inhibitors, an alternative scoring protocol, Principal Component Analysis (PCA), was proposed summarize most the information from original functions and re-rank results virtual screening against BACE-1. Method Given a training set (50 BACE-1 inhibitors 9950 inactive diverse compounds), three rank-based methods, individual scoring, conventional consensus PCA, were judged by hit number in top 1% ranked list. The...
Abstract Background The inhibition of the activity β-secretase (BACE-1) is a potentially important approach for treatment Alzheimer disease. To explore mechanism inhibition, we describe use 46 X-ray crystallographic BACE-1/inhibitor complexes to derive quantitative structure-activity relationship (QSAR) models. inhibitors were aligned by superimposing complexes, and gCOMBINE software was used perform COMparative BINding Energy (COMBINE) analysis on these minimized . major advantage COMBINE...
A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) strategy generating inhibitors interactions demonstrated that it can be used optimize fragment alternatives key determinants, combine these an effective way, this was achieved compounds cyclin-dependent kinase 2 (CDK2) substrate recruitment site on cyclin...
Abstract Aims/Introduction To assess the efficacy and safety of metformin/sitagliptin‐based dual/triple therapy in elderly Chinese patients with type 2 diabetes mellitus. Materials Methods This subgroup analysis included individuals aged ≥65 years from STRATEGY study, a two‐stage study which mellitus unsatisfactory glycemic control on metformin were first treated dual combination sitagliptin for 16 weeks ( n = 681), then, if had not been achieved, third add‐on oral antihyperglycemic drug...
Olfactory sense remains elusive regarding the primary reception mechanism. Some studies suggest that olfaction is a spectral sense, olfactory event triggered by electron transfer (ET) across odorants at active sites of odorant receptors (ORs). Herein we present Donor-Bridge-Acceptor model, proposing ET process can be viewed as an hopping from donor molecule to (Bridge), then off acceptor molecule, making electronic state change along with vibrations (vibronic transition). The specific...
As Multi-modal Large Language Models (MLLMs) evolve, expanding beyond single-domain capabilities is essential to meet the demands for more versatile and efficient AI. However, previous omni-models have insufficiently explored speech, neglecting its integration with multi-modality. We introduce Lyra, an MLLM that enhances multimodal abilities, including advanced long-speech comprehension, sound understanding, cross-modality efficiency, seamless speech interaction. To achieve efficiency...
Objectives: Sepsis is characterized by a severe inflammatory response to infection, and its complications, including hypotension, can be fatal. It has long believed that hypotension in sepsis occur as result of failure the vascular smooth muscle cells (VSMC) constrict. However, molecular mechanism links inflammation decreases vasoconstriction largely unknown. Approaches Results: CPI-17, key regulator vasoconstriction, was markedly decreased mesentery arteries (MA) mice injected with...
The blood pressure circadian rhythm was believed to be primarily controlled by the central pacemaker suprachiasmatic nucleus (SCN). This dogma challenged discoveries that each of clock genes present in SCN are also expressed and function peripheral tissues. But whether, if so how, involved remains uncertain. current study investigates role Bmal1, an obligatory core gene, plays smooth muscle regulation using a specific BMAL1 knockout mouse model (SM-Bmal1-KO). results show: 1) Smooth deletion...
Despite increasing prevalence of T2D in older Chinese people, no studies have evaluated the efficacy and safety DPP-4 inhibitor-based combination therapy this population. In STRATEGY Study (a multicenter, randomized, active-controlled, open-label clinical trial people with T2D), patients were treated for 20 weeks a SITA metformin (MET) (Phase 1). Those A1C ≥7.0% ≤10.0% at Week 16 randomly assigned to 1 4 additional AHAs continued treatment another 24 2). Here we report 681 aged ≥65 year. At...
Abstract Olfactory sense remains elusive regarding the primary reception mechanism. Some studies suggest that olfaction is a spectral sense, olfactory event triggered by electron transfer (ET) across odorants at active sites of odorant receptors (ORs). Herein we present Donor-Bridge-Acceptor model, proposing ET process can be viewed as an hopping from donor molecule to (Bridge), then off acceptor molecule, making electronic state change along with vibrations (vibronic transition). The...