A5036162806- Microplastics and Plastic Pollution
- biodegradable polymer synthesis and properties
- Recycling and Waste Management Techniques
- Electrospun Nanofibers in Biomedical Applications
- Effects and risks of endocrine disrupting chemicals
- Dementia and Cognitive Impairment Research
- Marine Biology and Environmental Chemistry
- Polymer Surface Interaction Studies
- Toxic Organic Pollutants Impact
- Cellular Mechanics and Interactions
- Oil Spill Detection and Mitigation
- Bone Tissue Engineering Materials
- Diet and metabolism studies
- Biomedical Ethics and Regulation
- Nutritional Studies and Diet
- Polymer Foaming and Composites
- Collagen: Extraction and Characterization
- RNA Interference and Gene Delivery
- Coastal and Marine Management
- Silk-based biomaterials and applications
- Sustainable Supply Chain Management
- Frailty in Older Adults
- Geriatric Care and Nursing Homes
- Diversity and Career in Medicine
- Animal testing and alternatives
Woods Hole Oceanographic Institution
2021-2025
Rush University Medical Center
2022-2025
Northeastern University
2024-2025
Rush University
2021-2025
Universidad del Noreste
2025
Woodwell Climate Research Center
2024
Illinois Institute of Technology
2024
University of Toronto
2019-2022
University of Florida
2012-2021
Diet may reduce Alzheimer dementia risk and slow cognitive decline, but the understanding of relevant neuropathologic mechanisms remains limited. The association dietary patterns with disease (AD) pathology has been suggested using neuroimaging biomarkers. This study examined Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Mediterranean β-amyloid load, phosphorylated tau tangles, global AD in postmortem brain tissue older adults.
Abstract The effect of particle aspect ratio and surface geometry on granular flows is assessed by performing numerical simulations rod-like particles in simple shear using the discrete element method (DEM). explored adopting two types particles: glued-spheres true cylindrical particles. varies from one to six. Compared frictionless spherical particles, smaller stresses are obtained for systems dilute moderately dense due loss translational energy, which partially converted rotational...
In May 2021, the M/V X-Press Pearl cargo ship caught fire 18 km off west coast of Sri Lanka and spilled ∼1680 tons spherical pieces plastic or "nurdles" (∼5 mm; white in color). Nurdles are preproduction used to manufacture a wide range end products. Exposure combustion, heat, chemicals led agglomeration, fragmentation, charring, chemical modification plastic, creating an unprecedented complex spill visibly burnt unburnt nurdles. These span continuum colors, shapes, sizes, densities with...
While plastic pollution threatens ecosystems and human health, the use of products continues to increase. Limiting its harm requires design strategies for informed by threats that plastics pose environment. Thus, we developed a sustainability metric ecodesign with low environmental persistence uncompromised performance. To do this, integrated degradation rate into established material selection strategies, deriving indices persistence. By comparing impact on-the-market proposed alternatives,...
Nonpersistence in natural environments with benign degradation products is a growing design criterion for consumer plastics. However, data on their biodegradation rates and environmental lifetimes the coastal ocean are lacking, limiting informed engineering regulatory decisions. Single-use drinking straws, common marine litter relevant to key stakeholders, exemplify this. To fill this knowledge gap, commercial straws made of cellulose diacetate (CDA), polyhydroxyalkanoates (PHA), paper,...
Abstract INTRODUCTION There is limited evidence about factors related to the timeliness of dementia diagnosis in healthcare settings. METHODS In five prospective cohorts at Rush Alzheimer's Disease Center, we identified participants with incident based on annual assessments and examined timing diagnoses Medicare claims. We assessed sociodemographic, health, psychosocial correlates timely diagnosis. RESULTS Of 710 participants, 385 (or 54%) received a claims within 3 years prior or 1 year...
In May 2021, the M/V X-Press Pearl container ship burned for 2 weeks, leading to largest maritime spill of resin pellets (nurdles). The disaster was exacerbated by leakage other cargo and ship's underway fuel. This affords unique opportunity study a time-stamped, geolocated release plastic under real-world conditions. Field samples collected from beaches in Sri Lanka nearest comprised nurdles exposed heat combustion, burnt pieces (pyroplastic), oil-plastic agglomerates (petroplastic). An...
The vascular mechanical microenvironment consists of a mixture spatially and temporally changing forces. This exposes endothelial cells to both hemodynamic forces (fluid flow, cyclic stretching, lateral pressure) vessel (basement membrane topographical properties). is "complex" because these are dynamic interrelated. Endothelial sense through mechanosensory structures transduce them into functional responses via mechanotransduction pathways, culminating in behavior directly affecting health....
Abstract Hydrogels have gained interest for use in tissue regeneration and wound healing because of their absorbing swelling properties as well ability to mimic the natural extracellular matrix. Their specifically may be form a patch or dressing they administered within bed filler, gel situ, promote healing. Thiolated hyaluronic acid‐polyethylene diacrylate (tHA‐PEGDA) hydrogels are ideal this purpose due short gelation times at physiological temperature pH. But these alone not enough...
In late May 2021, the M/V X-Press Pearl container ship caught fire while anchored 18 km off coast of Colombo, Sri Lanka and spilled upward 70 billion pieces plastic or "nurdles" (∼1680 tons), littering country's coastline. Exposure to combustion, heat, chemicals, petroleum products led an apparent continuum changes from no obvious effects consistent with previous reports melted burned (pyroplastic) found on beaches. At middle this continuum, nurdles were discolored but appeared retain their...
Sunlight transforms plastic into water-soluble products, the potential toxicity of which remains unresolved, particularly for vertebrate animals. We evaluated acute and gene expression in developing zebrafish larvae after 5 days exposure to photoproduced (P) dark (D) leachates from additive-free polyethylene (PE) film consumer-grade, additive-containing, conventional, recycled PE bags. Using a "worst-case" scenario, with concentrations exceeding those found natural waters, we observed no...
Popularized on social media, hand-moldable plastics are formed by consumers into tools, trinkets, and dental prosthetics. Despite the anticipated dermal oral contact, manufacturers share little information with about these materials, which typically sold as microplastic-sized resin pellets. Inherent to their function, moldable pose a risk of exposure unknown leachable substances. We analyzed 12 advertised for modeling applications determined them be polycaprolactone (PCL) or thermoplastic...
The remarkable underwater adhesion capacity of the invasive freshwater mussel species Dreissena polymorpha (zebra mussel) causes extensive damage each year. adhesive interface between substrate surface and mussels' plaques plays a key role in zebra biofouling. Silicone-oil-infused polydimethylsiloxane (iPDMS), an omniphobic material class liquid-infused slippery surfaces, has been shown to develop uniform, microscale, antifouling oil layer, which we hypothesized would be effective against...
ABSTRACT Background Ambulatory care is critical in delivering interventions for dementia and mild cognitive impairment (MCI), from basic services to novel therapeutics. Yet, little known regarding how community‐dwelling persons with dementia/MCI interact clinicians outpatient ambulatory settings. We assessed associations of evaluation management (E&M) visits. Methods included 2116 participants Rush Alzheimer's Disease Center cohorts, linked fee‐for‐service Medicare claims. Annually 2011...
Abstract INTRODUCTION We investigated the association of neighborhood disadvantage with incidence Alzheimer's disease and related dementias (ADRD) in longitudinal Black Women's Health Study (BWHS). METHODS The study included 10,915 BWHS participants enrolled Medicare for at least 1 year from 2012 to 2020. Area Deprivation Index (ADI) was assigned participant residential block groups over follow‐up. ADRD cases were identified files. RESULTS Age‐ education‐adjusted hazard ratios (HRs)...
Cigarette filters (CFs) are the most littered items on planet, but their fate in coastal ocean is unknown. The results of this study demonstrate that unsmoked cellulose diacetate...
Cellulose diacetate (CDA), a bio-based material widely used in consumer products, is biodegradable the coastal ocean. However, effect of water temperature on biodegradation rates unknown, limiting projections lifetime across space and time. Here, we incubated CDA-based materials (film, foam, straw), paper straws, polyethylene (PE) films, polybutylene adipate terephthalate (PBAT) straws for 28 weeks at 10 20 °C continuous-flow seawater mesocosms. The relative mass loss CDA film, straw...