A5004062872- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Reactivity of Heterocycles
- Synthesis and Catalytic Reactions
- Signaling Pathways in Disease
- Eicosanoids and Hypertension Pharmacology
- Synthesis and Characterization of Heterocyclic Compounds
- Supramolecular Self-Assembly in Materials
- Oxidative Organic Chemistry Reactions
- Inflammatory mediators and NSAID effects
- Organic Chemistry Cycloaddition Reactions
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Pyrroles
- Molecular Sensors and Ion Detection
Texas State University
2020-2024
Universidad San Marcos
2020
University of Kansas
2015-2018
A reaction of nitroalkanes with heterocycles possessing a 2-hydrazinylpyridine moiety leading to triazole-fused polyheterocyclic systems neuroblastoma differentiation activity was discovered.
Abstract Sphaeropsidins are iso -pimarane diterpenes produced by phytopathogenic fungi that display promising anticancer activities. Sphaeropsidin A, in particular, has been shown to counteract regulatory volume increase, a process used cancer cells avoid apoptosis. This study reports the hemi-synthesis of new lipophilic derivatives obtained modifications C15,C16-alkene moiety. Several these compounds triggered severe ER swelling associated with strong proteasomal inhibition and consequently...
A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition primary and secondary amines across double bond cyclopropene-3-carboxamides, followed by ring-opening resulting donor–acceptor cyclopropanes subsequent <italic>in situ</italic> reduction enamine intermediates.
A strain-release-driven, cation-templated intramolecular nucleophilic addition of tethered alkoxides to prochiral cyclopropenes is described. Employment chiral β- and γ-amino allowed for highly diastereoselective assembly a small series enantiopure cyclopropane-fused oxazepanones. It was shown that the center at C-4 plays crucial role in controlling desymmetrization cyclopropenyl moiety, instigated by profound potassium-templated effect. The preliminary biological activities new medium...
In a search of small molecules active against apoptosis-resistant cancer cells, including glioma, melanoma, and non-small cell lung cancer, we previously prepared α,β- γ,δ-unsaturated ester analogues polygodial ophiobolin A, compounds capable pyrrolylation primary amines demonstrating double-digit micromolar antiproliferative potencies in cells. the current work, synthesized dimeric trimeric variants such an effort to discover that could crosslink biological amine containing targets. We...
An unusual reaction is described, involving a formal intramolecular nucleophilic substitution of bromocyclopropanes with nitrogen ylides generated in situ from N-benzyl carboxamides. It shown that this involves cyclopropene intermediates and allows for the facile expeditious preparation 3-azabicyclo[3.1.0]hexan-2-one scaffolds.
A strain-release-driven, cation-templated nucleophilic 7- and 8-exo-trig-cyclization of tethered Boc-protected amines to cyclopropenes is described. The featured reaction proceeds in diastereo- regioselective fashion allows for preparation the corresponding 2,5-diazabicyclo[5.1.0]octan-6-ones 2,6-diazabicyclo[6.1.0]nonan-7-ones as sole products high yields. Preliminary studies on anticancer activities these novel cyclopropane-fused medium heterocycles were performed.
The tandem addition of an amine and a thiol to aromatic dialdehyde engages selective three-component assembly fluorescent isoindole. While attractive approach for diversity-based fluorophore discovery, isoindoles are typically unstable present considerable challenges their practical utility. We found that introduction electron-withdrawing substituents into the component affords stable isoindole products in one step with acceptable yields high purity.
A pocket-templated Paal–Knorr reaction delivers fluorescent COX-2 probes.
Abstract The title synthesis follows the nucleophilic addition, ring‐opening of resulting cyclopropanes, and in‐situ reduction enamine or imine intermediates sequence.