A5071214551- Colorectal Cancer Surgical Treatments
- Appendicitis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Microscopic Colitis
- Genetic factors in colorectal cancer
- Gallbladder and Bile Duct Disorders
- Anorectal Disease Treatments and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Minimally Invasive Surgical Techniques
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Hernia repair and management
- Bariatric Surgery and Outcomes
- Pelvic floor disorders treatments
- Venous Thromboembolism Diagnosis and Management
- Intestinal Malrotation and Obstruction Disorders
- Biliary and Gastrointestinal Fistulas
- Epigenetics and DNA Methylation
- Adenosine and Purinergic Signaling
St. Vincent's University Hospital
2016-2025
University College Dublin
2013-2024
Pennsylvania State University
2024
Hospital Universitario Virgen del Rocío
2023
Karolinska University Hospital
2023
University of Alabama at Birmingham
2013-2021
St Michael’s Hospital
2021
Royal Derby Hospital
2021
University of Nottingham
2021
Queen Elizabeth Hospital
2016
Ileal pouch anal anastomosis (IPAA) is the treatment of choice for chronic, medically refractory mucosal ulcerative colitis, indeterminate familial adenomatous polyposis (FAP), and a select group patients with Crohn's disease.: We report outcomes, complications, quality life (QOL) in cohort 3707 treated at our institution from January 1984 to March 2010.Data were collected prospectively maintained database chart review consecutive primary IPAA cases. Patient demographics, postoperative...
Inclusion of the mesentery during resection for colorectal cancer is associated with improved outcomes but has yet to be evaluated in Crohn's disease. This study aimed determine rate surgical recurrence after inclusion ileocolic disease.Surgical rates were compared between two cohorts. Cohort A [n = 30] underwent conventional where was divided flush intestine. B 34] which included excision mesentery. The relationship mesenteric disease severity and determined a separate cohort 94]. activity...
Lynch syndrome is one of the most common cancer susceptibility syndromes. Individuals with have a 50%–70% lifetime risk colorectal cancer, 40%–60% endometrial and increased risks several other malignancies. It caused by germline mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2. In subset patients, 3' end deletions EPCAM gene, which can lead to epigenetic silencing closely linked MSH2. Relying solely on age family history based criteria inaccurately identifies eligibility for...
Pyogenic hepatic abscesses are relatively rare, though untreated uniformly fatal. A recent paradigm shift in the management of liver abscesses, facilitated by advances diagnostic and interventional radiology, has decreased mortality rates. The aim this study was to review our experience managing pyogenic abscess, literature field, propose guidelines aid current complex disease.Demographic clinical details all patients admitted a single institution with abscess over 5 year period were...
Organ preservation has been proposed as an alternative to radical surgery for rectal cancer reduce morbidity and mortality, improve functional outcome.Locally advanced non-metastatic cancers were identified from a prospective database. Patients staged ⩾T3 or any stage N+ referred neoadjuvant chemoradiotherapy (CRT) (50-54 Gy 5-fluorouracil), reassessed 6-8 weeks post treatment. An active surveillance programme ('watch wait') was offered patients who found have complete endoluminal response....
Identifying hospitalized patients with acute severe ulcerative colitis (ASUC) who will be refractory to corticosteroid therapy and require rescue remains difficult. Hypoalbuminemia worsens time during hospitalization is associated rapid clearance of reduced response infliximab (IFX) rescue. Early use may therefore more effective. Simple clinical laboratory predictors responsiveness would facilitate earlier therapy.Retrospective study a prospectively maintained database 3600 attending single...
Abstract Background The incidence of rectal cancer among adults aged less than 50 years is rising. Survival data are limited and conflicting, the oncological benefit standard neoadjuvant adjuvant therapies unclear. Methods Disease-specific outcomes patients diagnosed with undergoing surgical resection curative intent between 2006 2016 were analysed. Results A total 797 identified, whom 685 had surgery intent. Seventy younger 615 or more. Clinical stage did not differ two age groups. Patients...
Background Akkermansia muciniphila and Desulfovibrio spp. are commensal microbes colonising the mucus gel layer of colon. Both species have capacity to utilise colonic mucin as a substrate. A. degrades mucin, while metabolise sulfate moiety sulfated mucins. Altered abundances these microorganisms been reported in ulcerative colitis (UC). However their bind human whether this binding is affected by changes associated with UC, remain be defined. Methods Mucin was isolated from resected colon...
To evaluate whether changes in expression of CD39 by regulatory T lymphocytes (Treg) impact treatment response inflammatory bowel disease. then define the biological role on Treg an animal model colitis.A prospective study consecutive patients commencing anti-tumor necrosis factor therapy with infliximab (IFX) or adalimumab (ADA), who were followed for 12 months. Treatment responses defined both symptomatically and endoscopy showing mucosal healing. Peripheral blood Tregs quantified flow...
Tumour budding (TB) is a marker of tumour aggressiveness which, when measured in rectal cancer resection specimens, predicts worse outcomes and response to neoadjuvant therapy. We investigated the utility TB assessment setting treatment.
Serial analysis of gene expression (SAGE) is a powerful tool for the discovery novel tumor markers. The publicly available on-line SAGE libraries normal and neoplastic tissues (http://www.ncbi.nlm.nih.gov/SAGE/) have recently been expanded; in addition, more complete annotation human genome better biocomputational techniques substantially improved assignment differentially expressed "tags" to genes. These improvements provided us with an opportunity re-evaluate global pancreatic cancer using...
Hedgehog pathway overactivity has been implicated in the development of a variety human cancers. The Human interacting protein (HHIP), negative regulator hedgehog signaling, shown to be underexpressed pancreatic In this study we determined if HHIP gene is target for genetic and epigenetic alterations. While no mutations were identified, found complete methylation promoter CpG island three cancer cell lines, partial hypermethylation 13/17 (80%) 35/75 (46%) primary cancers 14/18 (78%)...