A5085019268- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Analytical Methods in Pharmaceuticals
- RNA Interference and Gene Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Protein purification and stability
- Nanoplatforms for cancer theranostics
- Berberine and alkaloids research
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- Dermatology and Skin Diseases
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Ocular Surface and Contact Lens
- Innovative Microfluidic and Catalytic Techniques Innovation
- COVID-19 and Mental Health
- Plant-based Medicinal Research
- Enzyme function and inhibition
- Natural Antidiabetic Agents Studies
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
Northern Border University
2016-2025
American Pharmacists Association
2017-2021
Hamdard University
2011-2014
Introduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. Thus, this study aimed develop rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) improve Methods: The RL-SNEDDS was prepared by titration method eucalyptus oil (oil phase), tween 80 (surfactant), PEG 400 (co-surfactant) optimization performed 3 2 factorial design. optimized...
Tenofovir (TNF) is a common component of many antiretroviral therapy regimens, but it associated with poor membrane permeability and low oral bioavailability. To improve its bioavailability permeability, self-emulsifying drug delivery system (SEDDS) was developed characterized, relative compared to the marketed tablets (Tenof). Based on solubility ternary phase diagram analysis, eucalyptus oil selected as an phase, Kolliphor EL, Kollisolv MCT 70 were chosen surfactant cosurfactant,...
This research work aimed to develop and evaluate proniosomes for the oral delivery of lipophilic drug Irbesartan (IRB) improve its solubility bioavailability. Proniosomes were formulated using a lipid, surfactant, carrier by slurry method. Based on prepared preliminary trial batches their evaluation, formulation was optimized employing Box–Behnken design (BBD) in which concentrations span 60 (X1), cholesterol (X2), mannitol (X3) used as three independent variables vesicular size (VS) (Y1), %...
Etoricoxib (ETB) is a nonsteroidal anti-inflammatory therapeutic agent. It poorly soluble and has various gastrointestinal side effects such as bleeding ulcers after oral administration. The present research aimed to develop an ETB-loaded mesoporous silica nanoparticle-laden gel (ETB-MSNPs) for transdermal delivery improve efficacy. ETB-MSNPs were synthesized using precipitation solvent evaporation technique their optimization was performed Box-Behnken design. optimized incorporated into...
Aim: The optimisation and evaluation of ethosomal nanogel (NGs) for topical delivery in skin cancer.Methods: formulations were optimised by employing 3-factor, 3-level Box Behnken design responses vesicle size, fluxes. They characterised vitro evaluated drug release, permeation retention, penetration ethosome, electron microscopy, texture analysis, cytotoxicity.Results: formulation exhibited z-average 125.67 ± 10.43 nm, apparent zeta potential –17.1 2.61 mV, average flux loaded ethosome...
The phytogenous alkaloid berberine (BBR) has become a potential drug for the treatment of diabetes, hyperlipidemia, and cancer. However, its therapeutic is limited because ofpoor intestinal absorption due to efflux by P-gp expressed in lumen. Therefore, we aimed design fabricate nanoparticulate system delivery BBR employing naturally derived biodegradable biocompatible polymers, mainly chitosan alginate, enhance oral bioavailability BBR. A chitosan-alginate nanoparticle loaded with (BNPs)...
The novel human coronavirus disease (COVID-19) is the major pandemic throughout globe and its occurrence due to presence of severe acute respiratory syndrome (SARS-CoV2). That began from Wuhan, Hubei province China in late 2019 afterward drastically spread worldwide. It effects around 213 countries territories have reported a total 8,128,490 confirmed cases COVID-19. As an unprecedented global it sweeps planet affects each every being either physically, mentally or economically. most common...
The aim of this study was to prepare and evaluate α-mangostin-loaded polymeric nanoparticle gel (α-MNG-PLGA) formulation enhance α-mangostin delivery in an epidermal carcinoma. poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were developed using the emulsion–diffusion–evaporation technique with a 3-level 3-factor Box–Behnken design. NPs characterized evaluated for particle size distribution, zeta potential (mV), drug release, skin permeation. formulated PLGA converted into...
This study aimed to develop and optimize karanjin-loaded ethosomal nanogel formulation evaluate its efficacy in alleviating symptoms of psoriasis an animal model induced by imiquimod. These nanogel, were formulated enhance drug penetration into the skin epidermal retention. Karanjin was taken formulate ethosomes due potential ani-psoriatic activity. Ethosomes using cold method 3
Abstract Anterior uveitis is one of the most prevalent forms ocular inflammation caused by infections, trauma, and other idiopathic conditions if not treated properly, it can cause complete blindness. Therefore, this study aimed to formulate evaluate dexamethasone sodium phosphate (DSP) loaded polyelectrolyte complex (PEC) nanoparticles (NPs) for treatment anterior uveitis. DSP-loaded PEC-NPs were formed through coacervation mixing low molecular weight chitosan anionic polymer carboxy methyl...
A lipid-based nanocarrier system is a novel technique for the delivery of poorly soluble drugs through topical delivery. This study developed dual-drug (luliconazole: LZ, and niacinamide: NM) loaded lipid (LN)-laden gel treatment vaginal candidiasis. The LNs were prepared using cholesterol soya-α-lecithin thin-film hydration technique. average vesicle size, polydispersity index, zeta potential optimized LZNMLNs 126.40 ± 1.30 nm, 0.276, -34.6 0.8 mV, respectively, formulation showed sustained...
Among primary brain tumors, glioma has one of the highest fatality rates. Routine chemotherapy often faces off-target drug loss and sub-optimal availability at tissue. The present study aims development transferrin-conjugated gemcitabine loaded poly (lactic co glycolic acid) nanoparticles (Tf-GB-PLGA-NPs) targeted strategy for cancer cell. GB-PLGA-NPs were prepared using solvent evaporation nanoprecipitation method then conjugated with Tf. formulation was characterized physicochemical...
Postmenopausal women frequently experience urinary incontinence (UI), a condition often overlooked due to social stigma and lack of awareness. This study aimed assess the risk factors that contribute development in postmenopausal women. Objective: To determine associated with Methods: is cross-sectional conducted at Uro-Gynae Unit Ayub Teaching Hospital, Abbottabad, on 126 patients, following approval from Ethical Committee using non-probability consecutive sampling technique. Data was...
Introduction: Escitalopram oxalate (ESCI) is a biopharmaceutical classification system (BCS) class II antidepressant drug, that suffers limited oral bioavailability due to extensive hepatic metabolism. Therefore, this study aimed develop and evaluate chitosan nanoparticles (CSNPs) embedded in an situ gel for intranasal (i.n) drug delivery. Methods: ESCl-loaded CSNPs were prepared by the ionic gelation method optimized using 32 factorial design. The incorporated into pH-sensitive composed of...