A5073219544- HIV Research and Treatment
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- HIV/AIDS drug development and treatment
- Autophagy in Disease and Therapy
- Multiple Sclerosis Research Studies
- Sirtuins and Resveratrol in Medicine
- Signaling Pathways in Disease
- Cardiovascular Disease and Adiposity
- HIV-related health complications and treatments
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Sleep and related disorders
- Neurogenetic and Muscular Disorders Research
- Bone health and osteoporosis research
- RNA modifications and cancer
- Circular RNAs in diseases
- Health and Lifestyle Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Restless Legs Syndrome Research
- Bone fractures and treatments
- Congenital Anomalies and Fetal Surgery
Universidad de Guadalajara
2013-2023
Sleep disorders are a widespread condition in patients with Parkinson's disease (PD), which has been linked to deregulation of the circadian cycle and therefore clock genes. The aim this study was evaluate effect melatonin (MEL) on PER1 BMAL1 genes PD. A double-blind, cross-over, placebo-controlled randomized clinical trial pilot conducted 26 stage 1-3 PD according Hoehn & Yahr scale, who received either 25 mg MEL or placebo at noon 30 min before bedtime for three months. relative expression...
MicroRNAs (miRNAs/miRs) may serve as therapeutic agents or targets in diseases which the expression of proteins plays an important role. The aim present study was to compare levels specific miRNAs, well their correlation with markers response antiretroviral (ARV) therapy, patients human immunodeficiency virus type 1 (HIV-1) infection and without resistance highly active therapy (HAART).miRNA assays were performed on plasma samples obtained from 20 HIV-1-positive patients. A total ten divided...
MicroRNAs are considered as potential biomarkers, agents, or therapeutic targets; few studies have addressed the expression of miRNAs in treatment-naïve patients infected with HIV-1. The aim this study was to assess plasma relative circulating miRNA profiles Mexican HIV/AIDS and healthy individuals using a commercial array. A low CD4+ T cell count high viral load were found all patients. Decreased miRNA-296-5p observed patients; moreover, only that showed differences between two groups....
During the antiretroviral era, individuals living with HIV continue to experience milder forms of HIV-associated neurocognitive disorder (HAND). Viral proteins, including Tat, play a pivotal role in observed alterations within central nervous system (CNS), mitochondrial dysfunction emerging as prominent hallmark. As result, our objective was examine expression genes associated mitophagy and biogenesis brain exposed HIV-1 Tat protein. We achieved this by performing bilateral stereotaxic...
Bone fractures are a worldwide public health concern. Therefore, improving understanding of the bone healing process at molecular level, which could lead to discovery potential therapeutic targets, is important. In present study, model open tibial with hematoma disruption, periosteal rupture and internal fixation in 6-month-old male Wistar rats was established, order identify expression patterns key genes their protein products throughout process. A shaft fracture produced using three‑point...
Antecedentes: Los pacientes con enfermedad de Parkinson (EP) suelen presentar trastornos neuropsiquiátricos, que son síntomas no motores disminuyen su calidad vida como depresión y ansiedad. Objetivo: Analizar el efecto la administración melatonina (MEL) sobre los niveles ansiedad en EP. Métodos: Se realizó un estudio piloto ensayo clínico cruzado, aleatorizado, doble ciego 26 EP estadios 1-3 Hoen Yahr, quienes recibieron 25 mg MEL o placebo al mediodía 30 minutos antes acostarse durante...
Background and aims . It has been suggested that mitochondrial dysfunction is relevant to Alzheimer disease (AD) some haplogroups could be related the risk of AD. Therefore, in this work we have genotyped mtDNA Mexican patients with AD their respective matched controls. Methods: Haplotyping 33 49 healthy control subjects was performed using polymerase chain reaction/digest identification key polymorphic sites genome. Results: Mitochondrial haplogroup A most frequent controls followed by B....