A5072102368- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Computational Drug Discovery Methods
- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Cholinesterase and Neurodegenerative Diseases
- Natural Antidiabetic Agents Studies
- melanin and skin pigmentation
- Histone Deacetylase Inhibitors Research
- Bioactive Compounds and Antitumor Agents
- Phytochemicals and Antioxidant Activities
- Protein Degradation and Inhibitors
- Free Radicals and Antioxidants
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Contact Dermatitis and Allergies
- Phytochemistry and biological activities of Ficus species
- Biochemical Analysis and Sensing Techniques
- Allelopathy and phytotoxic interactions
- Synthetic Organic Chemistry Methods
- Monoclonal and Polyclonal Antibodies Research
- Chemical synthesis and alkaloids
- Work-Family Balance Challenges
Pir Mehr Ali Shah Arid Agriculture University
2023-2025
International Islamic University, Islamabad
2018-2022
Preston University
2022
Bahria University
2019-2022
Islamic University
2021
Quaid-i-Azam University
2010-2020
Pakistan Institute of Engineering and Applied Sciences
2018-2019
Hamdard University
2017
Pakistan Council of Scientific & Industrial Research
2007
Abstract A sequence of new 5‐aryl/heteroaryl‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione derivatives were synthesized by condensing Meldrum's acid and triethyl orthoformate with differently substituted aromatic heteroaromatic amines in good to excellent yields. The chemical structures characterized spectroscopic techniques the entities evaluated for chymotrypsin urease inhibition. Interestingly, among derivatives, compound containing 5‐nitropyridin‐2‐yl ring exhibited dual inhibition activities IC 50...
Leishmaniasis, a neglected tropical disease affecting 0.7 to 1.3 million people annually, has only few toxic therapeutic options. This study describes the synthesis, structural characterization, in silico and vitro assessment of novel thiosemicarbazones coumarin incorporated isatins (6a-6m) as highly potent safe antileishmanial agents. Molecular docking was initially used determine binding these compounds active cavity target protein (Leishmanolysin gp63) Leishmania (L.) tropica. Among all...
In the present study, a new series of 1,2,3-triazole derivatives was synthesized via click one-pot reaction. The compounds were found to be active during molecular docking studies against targeted protein 1T69 by using Molecular Operating Environment (MOE) software. designed and characterized FT-IR, 1H-NMR LC-MS spectra. triazole moieties further screened for their α-amylase α-glucosidase inhibitory activities. preliminary activity analysis revealed that all showed good inhibition activity,...
In the present study, five 4-aminophenol derivatives (4-chloro-2-(((4-hydroxyphenyl)imino)methyl)phenol(S-1), 4-((4-(dimethylamino)benzylidene)amino)phenol(S-2), 4-((3-nitrobenzylidene)amino)phenol(S-3), 4-((thiophen-2-ylmethylene)amino)phenol(S-4) and 4-(((E)-3-phenylallylidene)amino)phenol(S-5)) were synthesized characterized by FT-IR, 1H-NMR, 13C-NMR elemental analyses. The compounds tested for their antimicrobial (Gram-positive Gram-negative bacteria Saccharomyces cervesea fungus)...
Alzheimer's disease, known to be associated with the gradual loss of memory, is characterized by low concentration acetylcholine in hippocampus and cortex part brain. Inhibition acetylcholinesterase has successfully been used as a drug target treat disease but resistance shown butyrylcholinesterase remains matter concern treating disease. Apart from many other reasons for its association genesis fibrils β-amyloid plaques closely related increased activity butyrylcholinesterase. Although few...
The current investigation employed rosuvastatin for evaluation as an antiarthritic agent by in vitro and vivo studies. In studies comprised egg albumin bovine serum protein denaturation assays along with membrane stabilization assays, while formaldehyde complete Freund's adjuvant (CFA)-provoked arthritis. antioxidant potential was estimated via DPPH free radical scavenging ferric reducing assays. Rosuvastatin significantly inhibited heat-provoked of a concentration-dependent way the highest...
In continuation to our efforts in finding potential therapeutic agents, a variety of biologically significant semicarbazones were synthesized by the reaction different carbonyl compounds with phenyl semicarbazides through microwave irradiation. Initially, 18 studied for their antimicrobial, antitumor, and antioxidant potential. None tested showed any antibacterial activity; however, some antifungal activity. Interestingly, all antitumor activity when against tumors grown on potato discs....
Thermally stable, high performance sulfonated copolyimide adsorbents [OBM (ODPA+BDSA·TEA+MDA) and FBM (6FDA+BDSA·TEA+MDA)] having excellent adsorption ability were prepared via a two-step thermal imidization reaction. By the introduction of hydrophilic sulfonic acid groups into polyimide backbone, material's hydrophilicity was improved. The anionic sulfonate group bears strong affinity toward heavy metal ions. Improvement in polymer enhances ion capacity due to feasible access sites. Atomic...
Various N- and S-containing 5-membered heterocycles such as imidazole-2-thiones, thiazolidinones thiazolidin-2-imines are among the most eminent biologically active organic present in many marketed drugs. In view of their synthetic biological significance, an efficient synthesis two novel thiazolidine-2-imines (4a-b) utilizing a three-component one-pot approach starting from aldimine, alkyne isothiocyanates has been developed. The reaction proceeded via 5-exo digonal (5-exo dig) cyclization...
Molecular docking procedure is well known for the investigation of small molecules; however, macromolecules, it has attained limited success so far. Thus, in an attempt, a series poly (azomethine) esters was synthesized laboratory, and their model oligomer units were studied by computer-aided computational MOE software package to investigate, specifically, binding modes that could influence anticancer activities. Poly ester (PAME) prepared solution phase polycondensation preformed Schiff...
Synthesis and characterization of novel copper complexes metronidazole benzoate (MTZ Benz), (MTZ) in the presence another ligand; dichloroacetic acid (DCA) were compared reported present work. Different bacterial fungus strains ascertained to evaluate biological potency synthesized complexes, that is, Escherichia coli, Bordetella bronceptica, Staphylococcus epidermidis, Baccilus pumilus, aureus yeast strain Saccharomyces cerevisiae. Agar diffusion method was employed investigate vitro...
Histone deacetylases have emerged as an important therapeutic target for the treatment of cancer. Genome-wide histone hypoacetylation causes many cancers. Recently, inhibitors (HDAC) class anticancer agents. Various side effects like myocardium damage and bone marrow depression even leading to cell death been observed in caner cells using HDAC inhibitors. The discovery development type-specific is both research clinical interests. Ligand based pharmacophore modelling playing a key role...
Type 2 diabetes is a metabolic disorder, characterised by hyperglycemia and glucose intolerance. Natural products its derived active compounds may be achievable alternatives for the treatment of type diabetes. In present study we investigated antidiabetic potential Ficus microcarpa isolated bioactive i.e. Plectranthoic acid A (PA-A) 3,4,5,7-Flavantetrol (FL). Anti-hyperglycemic was evaluated via α-glucosidase, α-amylase dipeptidyl peptidase 4 (DPP-4) assays. 5′AMP-activated kinase (AMPK)...