A5078544202- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Therapeutic Uses of Natural Elements
- Chronic Lymphocytic Leukemia Research
- Retinoids in leukemia and cellular processes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Complement system in diseases
- Prenatal Screening and Diagnostics
- Hematopoietic Stem Cell Transplantation
- Dermatological and COVID-19 studies
- Erythrocyte Function and Pathophysiology
- Parvovirus B19 Infection Studies
- Inflammatory Biomarkers in Disease Prognosis
- Immune Cell Function and Interaction
- Blood properties and coagulation
- Bone and Joint Diseases
- Platelet Disorders and Treatments
- Toxin Mechanisms and Immunotoxins
- Hemoglobinopathies and Related Disorders
- Global Cancer Incidence and Screening
- Immunodeficiency and Autoimmune Disorders
University of the Free State
2018-2025
National Health Laboratory Service
2018-2025
Hairy cell leukaemia (HCL) is a rare B-cell lymphoproliferative disorder characterised by medium-sized villous lymphocytes ('hairy cells') and monocytopenia in the peripheral blood. Automated full blood count (FBC) haematology analysers may spuriously 'hairy cells' as monocytes, resulting pseudomonocytosis. A 72-year-old woman presented with symptomatic anaemia massive splenomegaly to regional hospital North West province, South Africa, June 2023. An FBC differential count, performed on...
An HIV positive, early adolescent girl from rural Southern Africa required multiple hospital admissions for severe normocytic anaemia. As she was virologically suppressed on antiretrovirals, the initial anaemia workup focused nutritional deficiencies and excluding chronic haemolysis. A lack of readily available expertise resources contributed to a delay in investigations, during which treated symptomatically with blood transfusions. She later transferred tertiary where diagnosed parvovirus...
An HIV-negative South African woman in her 50s presented to hospital with fatigue. She had no medical history and is a Jehovah’s Witness. Her full blood count revealed macrocytic anaemia severe thrombocytopenia. On smear review, there were ±66% blasts lineage discerning morphological features. Peripheral flow cytometry blast population that expressed B-cell (CD19 dim, cCD79a CD10 CD22 moderate), T/NK-cell (CD7) myeloid markers (HLA-DR, CD33, CD117). However, antigen combinations did not...
Background: Leukaemias are haematological malignancies resulting from the abnormal clonal proliferation of haematopoietic precursors. Their incidence is influenced by various environmental and genetic factors.Aim: With this retrospective descriptive study, authors aimed to explore possible influence seasonality on type number acute leukaemia (AL) diagnoses made at Universitas Academic Hospital (UAH) National Health Laboratory Service (NHLS) 01 January 2018 31 December 2021.Setting: Hospital,...
Recognition of molecular abnormalities in acute myeloid leukaemia (AML) has improved our understanding its biology. NPM1 and FLT3-ITD mutations are recurrent AML clinically significant. associated with a favourable prognosis, while an independent poor prognostic factor AML.This study described the prevalence characteristics newly diagnosed patient cohort central South Africa.The included 40 de novo patients. An multiplex polymerase chain reaction assay was optimised to screen patients for...
Background: Targeted therapies combined with anthracycline chemotherapy have improved the survival of patients acute promyelocytic leukaemia (APL). High short-term mortality has been demonstrated in low- and upper-middle-income countries, limited local data.Aim: This study aimed to describe demographic variables, clinical characteristics laboratory features associated APL.Setting: The Division Clinical Haematology, Universitas Academic Hospital (UAH), Bloemfontein, South Africa.Methods:...
Background: Bone marrow aspirates and trephine biopsies (BMATs) form an important part of staging to detect bone metastases both haematological nonhaematological neoplasms.Aim: The study’s primary aim was determine whether it is necessary perform bilateral BMATs on paediatric cancer patients as opposed unilateral for the solid tumours.Setting: Paediatric Oncology Unit at Universitas Academic Hospital (UAH) in Bloemfontein, Free State, South Africa.Methods: A retrospective descriptive study...
Background: Targeted therapies combined with anthracycline chemotherapy have improved the survival of patients acute promyelocytic leukaemia (APL). High short-term mortality has been demonstrated in low- and upper-middle-income countries, limited local data. Aim: This study aimed to describe demographic variables, clinical characteristics laboratory features associated APL. Setting: The Division Clinical Haematology, Universitas Academic Hospital (UAH), Bloemfontein, South Africa. Methods:...