A5001306221- Celiac Disease Research and Management
- Microscopic Colitis
- Eosinophilic Esophagitis
- Genetic Neurodegenerative Diseases
- Digestive system and related health
- Dementia and Cognitive Impairment Research
- Viral Infections and Immunology Research
- Iron Metabolism and Disorders
- Down syndrome and intellectual disability research
- Intestinal Malrotation and Obstruction Disorders
- Glutathione Transferases and Polymorphisms
- Frailty in Older Adults
- Trace Elements in Health
- Intracerebral and Subarachnoid Hemorrhage Research
- Folate and B Vitamins Research
- ATP Synthase and ATPases Research
- Epilepsy research and treatment
- Anesthesia and Pain Management
- Epigenetics and DNA Methylation
- Cardiac Health and Mental Health
- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Olfactory and Sensory Function Studies
- Gastrointestinal disorders and treatments
- Metabolism and Genetic Disorders
Päijät-Hämeen Keskussairaala
2005-2022
University of Helsinki
2011
Helsinki University Hospital
2011
Imaging Center
2011
Tampere University
2001
Tampere University Hospital
2001
Neurology, Inc
1999
Abstract Background Celiac disease may emerge at any age, but little is known of its appearance in elderly people. We evaluated the prevalence condition individuals over 55 years and determined incidence biopsy-proven celiac (CDb) including seropositive subjects for anti-tissue transglutaminase antibodies (CDb+s). Methods The study based on figures 2815 randomly selected who had undergone a clinical examination serologic screening 2002. A second same population was carried out 2005,...
<b>Objectives:</b> A body of evidence shows that coeliac disease is associated with protean manifestations outside the intestine, and neurological disorders are well recognised. However, it remains obscure whether there signs clinical or subclinical nervous system involvement even in patients adopting an adequate gluten free diet. The aim this study was to assess a controlled treated carry increased risk for neuropathy characterise type possible neuropathy. <b>Methods:</b>...
Abstract Background The utility of serologic screening for celiac disease is still debatable. Evidence suggests that the disorder remains undetected even in older population. It obscure whether makes good or harm subjects with long-standing gluten ingestion. We evaluated benefit from active detection and subsequent free dietary treatment disease. Methods Thirty-five biopsy-proven patients aged over 50 years had been detected by mass screening. examined history, compliance, symptoms, quality...
Summary Background The revised paediatric criteria for coeliac disease allow omission of duodenal biopsies in symptomatic children who have specific serology and disease‐associated genetics. It remains unclear whether this approach is also applicable adults with various clinical presentations. Aim To evaluate the accuracy serology‐based variable pre‐test probabilities disease. Methods Three study cohorts comprised high‐risk suspicion (n = 421), moderate‐risk family members patients 2357),...
It is well known that coeliac disease may be associated with various neurological manifestations. We have had a high index of suspicion during recent years in our clinic. As result 10 (7%) out 144 new patients were detected because symptoms. The most common manifestations neuropathy, memory impairment and cerebellar ataxia. In these patient groups screening for serological antibody tests helps to find who suffer from this disease.
Objective: Mitochondrial DNA polymerase γ ( POLG1 ) mutations in children often manifest as Alpers syndrome, whereas adults, a common manifestation is mitochondrial recessive ataxia syndrome (MIRAS) with severe epilepsy. Because some patients MIRAS have presented or epilepsy already childhood, we searched for neurologic manifestations childhood. Methods: We investigated 136 children, all clinically suspected to disease, one more of the following: ataxia, axonal neuropathy, without known...
BACKGROUND. Neurological symptoms of unknown origin are common in coeliac disease (CD). Evidence suggests that CD may also contribute to the development idiopathic late-onset ataxia.AIM. To evaluate frequency patients with cerebellar ataxia origin.METHODS. The medical files adult diagnosis (n = 44) were evaluated. Serum gliadin, endomysial, and serum tissue transglutaminase antibodies used as screening tests for CD. Subjects positive results referred small-bowel biopsy.RESULTS. was high 9.1%...
Objective. Antigliadin antibodies (AGA) show good sensitivity but low specificity for celiac disease and can also be found in healthy individuals. However, data suggest that AGA positivity might related to distinct entities such as allergy gluten ataxia. Our aim here is explore the clinical relevance of positive elderly population. Material methods. Serum IgA- IgG-class IgA-class tissue transglutaminase (tTGA) were determined 2815 individuals aged 52–74 years. Equal numbers AGA-...
To examine the prevalence and effect of cognitive impairment on treatment outcomes in elderly patients undergoing arthroplasty to describe feasibility tests.The participants were 52 with a mean age 78 years 11 months (SD: 3.3), waiting for primary arthroplasty. We translated Montreal Cognitive Assessment (MoCA) into Finnish compared it Mini-Mental State Examination (MMSE), Mini-Cog, clock-drawing tests prior 3 after surgery. The ability perform activities daily living, depression, quality...
Patients with epilepsy and posterior cerebral calcifications have an increased risk of coeliac disease (CD). The occurrence this syndrome the overall CD remain still poorly understood. This study presents prevalence CD, brain atrophy, in patients unknown aetiology. medical records 900 consecutive adult diagnosis were reviewed. living aetiology (n = 199) was investigated; all without previously known asked for serological screening verified small bowel biopsy. presence occipital atrophy...
Venous thromboembolism (VTE) after primary intracerebral hemorrhage (ICH) worsens patient prognosis. Administering low-molecular weight heparins (LMWH) to prevent VTE early (24 h) may increase the risk of hematoma enlargement, whereas administering late (72 onset decrease its effect on prevention. The authors investigated when it is safe and effective start LMWH in ICH patients.In setting double blinded, placebo controlled randomization, patients >18 years age with paretic lower extremity,...
Alemtuzumab is an effective disease-modifying therapy (DMT) for highly active multiple sclerosis (MS). However, safety concerns limit its use in clinical practice.To evaluate the of alemtuzumab a nationwide cohort Finnish MS patients.In this retrospective case series study, we analyzed data all but two patients who had received Finland until 2019. Data were systematically collected from patient files.Altogether 121 identified, most whom previous DMTs (82.6%). Median follow-up time after...
Abstract Background Low ferritin without anaemia has been linked to adverse health effects. Objectives To investigate the prevalence and clinical significance of low in screen‐detected coeliac disease. Methods Seventy‐six disease patients were enrolled prospective collection comprehensive clinical, laboratory histological data at diagnosis after 1–2 years on a gluten‐free diet (GFD). All variables compared between with different levels. Results At diagnosis, six had anaemia. Of 70 nonanaemic...
ABSTRACT We describe an adult man with biopsy‐proven Rasmussen's encephalitis and intractable epilepsy, who underwent excellent recovery. To our knowledge, this is the first report of a patient has become completely symptomless, at least for three years, on enhanced antiepileptic immunological medication.
Objectives A variety of neurological and psychiatric disorders have recently been linked to coeliac disease gluten sensitivity. We here explored whether persistently positive gliadin antibodies (AGA) coeliac-type HLA increase the risk sensitivity-related manifestations. The study was carried out in an older population who had consumed for decades but no previous diagnosis. Materials Methods original comprised 4272 randomly selected individuals, whom 2089 AGA transglutaminase 2 (antiTG2)...
To explore if anti-gliadin antibody (AGA) positivity is associated with overall mortality or morbidity and especially the development of coeliac disease during long-term gluten exposure.The study population comprised 130 persistently AGA-positive but transglutaminase-2 (anti- TG2) -negative 52 AGA- anti-TG2 subjects aged 64-88 years. HLA-typing for DQ2 DQ8 (coeliac-type HLA) was performed on AGA-positives. The medical records were reviewed to compare a follow-up 12-13 years since initial...
In 1988, we assessed the adaptive skills of 45 adults with Down syndrome ( DS ) (21 women and 24 men, age 20–58) Portage scale. Since then, have followed them also screened for signs clinical dementia Present Psychiatric State – Learning Disabilities assessment. The mean AA study group decreased increasing age; 35 being turning point in course . was 4.4 years between ages 20 34, 3.4 49, 2.4 50 66. Inter‐individual variation was, however, large. Between 25, subjects ranged from 2.3 to 6...
The aim of this study was to determine the clinical utility Finnish version MoCA test for screening Alzheimer’s disease and MCI. purpose examine ability (sensitivity specificity) distinguish patients with AD MCI from cognitively normal controls. population consists three participant groups: (n=25), meeting criteria (n=18), controls (NC) (n=39). group subjects very mild (CDR= 0.5, n=12), (CDR=1, moderate (CDR=2, n=1) dementia, they were given a diagnosis dementia by using revised NINCDS-ARDRA...