A5085434309- Cardiac electrophysiology and arrhythmias
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-induced cardiotoxicity and mitigation
- HER2/EGFR in Cancer Research
- Heart Failure Treatment and Management
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Drug-Induced Adverse Reactions
- Cardiovascular and exercise physiology
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Pharmacological Receptor Mechanisms and Effects
- Potassium and Related Disorders
- Hormonal Regulation and Hypertension
- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Anesthesia and Sedative Agents
- Cardiac Arrhythmias and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
Université de Caen Normandie
2018-2025
Centre Hospitalier Universitaire de Caen Normandie
2018-2023
London School of Hygiene & Tropical Medicine
1980
Limited information is available on the safety of a rechallenge with an immune checkpoint inhibitor (ICI) after immune-related adverse event (irAE).To identify recurrence rate same irAE that prompted discontinuation ICI therapy in patients cancer and to clinical features associated such recurrences.This observational, cross-sectional, pharmacovigilance cohort study examined individual case reports from World Health Organization database VigiBase, which contains more than 130 countries. Case...
Background Immune checkpoint inhibitor (ICI)-associated early cardiac adverse events (CAEs), mostly acute and fulminant myocarditis, have been well characterized mainly occur during the first 90 days after ICI therapy initiation. ICI-associated late CAEs (occurring of treatment) not yet described. Methods First, we compared characteristics a cohort involving (defined as CAE time to onset (TTO) <90 initiation) TTO ≥90 consecutive cases who were referred three French cardio-oncology units....
The explosion of novel anticancer therapies has meant emergence cardiotoxicity signals including atrial fibrillation (AF). Reliable data concerning the liability drugs in inducing AF are scarce. Using World Health Organization individual case safety report database, VigiBase®, we aimed to determine association between and AF.A disproportionality analysis evaluating multivariable-adjusted reporting odds ratios for with their 99.97% confidence intervals was performed 176 U.S. Food Drug...
The incidence of atrial fibrillation (AF) associated with anticancer drugs in cancer patients remains incompletely defined.The primary outcome was the annualized rate AF reporting exposure to 1 19 used as monotherapy clinical trials. authors also report reported placebo arms these trials.The systematically searched ClinicalTrials.gov for phase 2 and 3 trials studying different interest monotherapy, up September 18, 2020. performed a random-effects meta-analysis compute summary its 95% CI...
Postoperative atrial fibrillation (POAF) is associated with poor outcomes after coronary artery bypass graft (CABG) surgery. We aimed to assess the additional value of preoperative plasma aldosterone levels, a biomarker promoting proarrhythmic and profibrotic pathways, for predicting POAF CABG.We conducted prospective cohort study involving consecutive patients left ventricular ejection fraction (LVEF) more than 50% requiring elective CABG in our university hospital. Plasma two-dimensional...
Therapeutic advancements have significantly enhanced cancer patient survival rates, yet concomitantly increased the prevalence of associated toxicities, such as therapy-related cardiac dysfunction (CTRCD), either symptomatic (heart failure) or not. Using World Health Organization's VigiBase® individual case safety report database, aim was to establish association between anticancer drugs and CTRCD reporting. This study a disproportionality analysis conducted in from initial any drug until...
Whether oral anticoagulants, vitamin K antagonists (VKAs), and nonvitamin anticoagulant (NOACs) frequently prescribed to atrial fibrillation (AF) patients, do themselves have a pro- or anti-arrhythmic effect never been addressed. Transmembrane action potentials were recorded in an acute rabbit model of superfused pulmonary veins (PVs) sleeves preparations using standard microelectrode technique. Fluindione 10 μm (n = 6) increased the AP (action potential) duration (APD), induced...
This report describes the case of a 48-year-old man whose electrocardiogram after cardiopulmonary resuscitation showed up-sloping ST-segment depression at J point in precordial leads combined with tall symmetrical T waves. electrocardiographic pattern corresponded to de Winter syndrome and is related proximal left anterior descending coronary artery occlusion. (Level Difficulty: Beginner.)
Conference Abstract| September 01 1980 Fitness and the Respiratory Response to Exercise R. B. Douglas; Douglas 1London School of Hygiene Tropical Medicine, London Search for other works by this author on: This Site PubMed Google Scholar S. Brittain; Brittain 2London P. T. Brooks; Brooks 3London Carson; Carson 4London J. Farrow; Farrow 5London L. Holve; Holve 6London A. D. Hughes; Hughes 7London I. Kong; Kong 8London Mead; Mead 9London Plane; Plane 10London E. Robinson; Robinson 11London...