A5112247524- Monoclonal and Polyclonal Antibodies Research
- Parkinson's Disease Mechanisms and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cancer-related gene regulation
- Nuclear Receptors and Signaling
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
Michigan United
2020
Korea Institute of Radiological and Medical Sciences
2018
Konkuk University
2017-2018
Monoclonal antibodies against TNFα, including infliximab, adalimumab, golimumab, and certolizumab pegol, are widely used for the treatment of inflammatory diseases such as rheumatoid arthritis bowel disease. Recently, crystal structures in complex with Fab fragments infliximab have revealed molecular mechanisms these antibody drugs. Here, we report structure TNFα fragment pegol to clarify precise antigen-antibody interactions structural basis neutralization by this therapeutic antibody. The...