A5057450326- Cell death mechanisms and regulation
- T-cell and B-cell Immunology
- Chronic Myeloid Leukemia Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- RNA and protein synthesis mechanisms
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- RNA Interference and Gene Delivery
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Cancer-related gene regulation
- Animal Genetics and Reproduction
- Eosinophilic Disorders and Syndromes
- Bacteriophages and microbial interactions
- CRISPR and Genetic Engineering
- Phagocytosis and Immune Regulation
Walter and Eliza Hall Institute of Medical Research
2014-2024
MRC Laboratory of Molecular Biology
1968-2022
Medical Research Council
1968-2022
University of Geneva
1970-2022
Institute of Molecular Biology and Biophysics
2022
Yale University
2022
The University of Melbourne
1967-2020
Texas A&M University
2017
Australian Academy of Science
2013
The Royal Melbourne Hospital
1994-2007
The biological functions of the BCL2 gene were investigated in transgenic mice harboring human cDNA under control an immunoglobulin heavy chain enhancer (E mu). Mice a representative strain, E mu-bcl-2-22, had great excess B lymphocytes, immunoglobulin-secreting cells, and serum immunoglobulins, attributable to increased longevity B-lineage cells. Pre-B plasma cells as well exhibited prolonged survival culture. Immunized animals produced amplified protracted antibody response. Within first...
In transgenic mice, self-reactive B lymphocytes are eliminated if they encounter membrane-bound self antigens during their development within the bone marrow. We show here that two separate and sequential events, arrested cell death, bring about elimination. Developmental arrest is an early outcome of antigen binding in immature cells, blocks acquisition adhesion molecules receptors important for migration activation, rapidly reversible by removal antigen. Death cells occurs 1 to 3 days can...
Impaired apoptosis is now recognized to be central tumor development. Bcl2, activated by chromosomal translocation in human follicular lymphoma, promotes oncogenesis inhibiting apoptosis. Bim, a distant proapoptotic relative, emerging as major physiologic antagonist of Bcl2. Here, we show that loss Bim oncogenic. protein levels were elevated the apoptosis-prone B lymphoid cells Eμ- Myc -transgenic mice, and -mutant mice had increased numbers IgM-bearing cells. -expressing deficient...