A5077227816- Synthetic Organic Chemistry Methods
- Various Chemistry Research Topics
- Innovative Teaching and Learning Methods
- Asymmetric Synthesis and Catalysis
- Protein Structure and Dynamics
- Experimental Learning in Engineering
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Hemoglobin structure and function
- Chemical synthesis and alkaloids
- Autism Spectrum Disorder Research
- Higher Education Learning Practices
- Synthesis and biological activity
- Science Education and Pedagogy
- Histone Deacetylase Inhibitors Research
- Oxidative Organic Chemistry Reactions
- Research in Social Sciences
- Disability Education and Employment
- Educational Strategies and Epistemologies
- Academic Writing and Publishing
- Innovative Teaching Methods
- Protein Interaction Studies and Fluorescence Analysis
- Peptidase Inhibition and Analysis
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Reactions
Hobart and William Smith Colleges
2015-2020
Durham University
2009
University of North Carolina at Chapel Hill
2006
Indazoles are unselectively protected under strongly basic conditions to give a mixture at N-1 and N-2. Under mildly acidic conditions, regioselective protection N-2 takes place. Thermodynamic lead N-1. This trend applies various substituted indazoles. Protected 5-bromoindazoles participate in Buchwald reactions with range of amines generate novel derivatives.
The enantioselective synthesis of the carbon skeleton 6-deoxyerythronolide B has been achieved in 23 linear steps from propionaldehyde. relies on an iterative approach employing asymmetric acyl-thiazolidinethione propionate aldol reaction to establish eight nine stereogenic centers. remaining center at C6 was set through a Myers alkylation complex alkyl iodide.
To understand the consequences of macromolecular crowding, studies have largely employed in vitro experiments with synthetic polymers assumed to be both pure and "inert". These alter enzyme kinetics by excluding volume that would otherwise available enzymes, substrates, products. Presented here is evidence other factors, addition excluded volume, must considered interpretation crowding polymers. Dextran has a weaker effect on Michaelis-Menten kinetic parameters yeast alcohol dehydrogenase...
A 10 week project in the organic chemistry laboratory provided opportunity to require students write four drafts of an introduction. Student understanding what a good introduction entails was transformed by their fourth draft, as evidenced higher citation counts and inclusion more better figures, which reveals greater student engagement with primary literature. In initial implementation project, writing subsections final report throughout semester had unfortunate effect creating loosely...
The first-semester introductory organic chemistry laboratory has been adapted to include mini postlab assignments that students must complete correctly, through as many attempts prove be necessary. use of multiple drafts writing is a standard approach improving writing, so the system was designed require for involve calculations, NMR interpretation, creation good figures, and other nonwriting forms analysis. created pay attention faculty feedback review their own work. Scores on written lab...
We describe the synthesis of Xyzidepsin, a depsipeptidic analogue HDAC inhibitor Romidepsin (FK228), using solid-phase strategy. Our latent thioester linker was synthesized in 92% yield (three steps). Chemoselective conditions unmasked functionality and cyclized macrocycle. An IC50 value 0.50 μM ± 0.05 obtained for U937 cells. This synthetic route, well-suited to SAR, represents generalizable route toward all manner analogues, including structures with acidic basic amino acids.
Classroom behavior problems can be lessened or eliminated by the use of effective cuing.
AbstractAfter a grueling grading campaign, chemist asked writing and rhetoric specialist for help improving formal reports in the introductory organic chemistry lab. Together, we realized that very best student employ many persuasive moves combined results discussion subsection, whereas weaker papers omit language. To make students aware of need language throughout their reports, then developed reworked assignment prompt lab-period-long workshop, which highlight by walking through three key...
Teachers of the learning disabled must consider many different factors to minimize transition difficulties.