Katarzyna Łepeta

ORCID: 0000-0002-6870-0009
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About
Contact & Profiles
Research Areas
  • Neuroscience and Neuropharmacology Research
  • Signaling Pathways in Disease
  • Cellular transport and secretion
  • Photoreceptor and optogenetics research
  • Cellular Mechanics and Interactions
  • Genetics and Neurodevelopmental Disorders
  • Viral Infectious Diseases and Gene Expression in Insects
  • Monoclonal and Polyclonal Antibodies Research
  • Virus-based gene therapy research
  • Retinal Development and Disorders
  • Microtubule and mitosis dynamics
  • Protease and Inhibitor Mechanisms
  • Light effects on plants
  • Neural dynamics and brain function
  • Hippo pathway signaling and YAP/TAZ
  • Celiac Disease Research and Management
  • Protist diversity and phylogeny
  • Alzheimer's disease research and treatments
  • Cancer Research and Treatments
  • CRISPR and Genetic Engineering
  • Peptidase Inhibition and Analysis
  • Nutrition and Health Studies
  • Autism Spectrum Disorder Research

University of Basel
2021-2025

Polish Academy of Sciences
2016-2017

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2016-2017

University of Warsaw
2010-2012

Abstract Matrix metalloproteinase 9 ( MMP ‐9) has recently emerged as a molecule that contributes to pathological synaptic plasticity in schizophrenia, but explanation of the underlying mechanisms been missing. In present study, we performed phenotype‐based genetic association study PGAS ) > 1,000 schizophrenia patients from Göttingen Research Association for Schizophrenia GRAS data collection and found an between ‐9 rs20544 C/T single‐nucleotide polymorphism SNP located 3′untranslated...

10.15252/emmm.201707723 article EN cc-by EMBO Molecular Medicine 2017-06-16

Abstract Post-translational modifications (PTMs) are indispensable modulators of protein activity. Most cellular behaviours, from cell division to cytoskeletal organization, controlled by PTMs, their mis-regulation being associated with a plethora human diseases. Traditionally, the role PTMs has been studied employing biochemical techniques. However, these approaches fall short when studying PTM dynamics in vivo. In recent years, functionalized binders have allowed post-translational...

10.1093/g3journal/jkaf073 article EN cc-by G3 Genes Genomes Genetics 2025-04-07

Post-translational modifications (PTMs) are indispensable modulators of protein activity. Most cellular behaviours, from cell division to cytoskeletal organization, controlled by PTMs, their miss-regulation being associated with a plethora human diseases. Traditionally, the role PTMs has been studied employing biochemical techniques. However, these approaches fall short when studying PTM dynamics in vivo. In recent years, functionalized binders have allowed post-translational modification...

10.1101/2024.11.27.625702 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-11-27

Reversible protein phosphorylation by kinases controls a plethora of processes essential for the proper development and homeostasis multicellular organisms. One main obstacle in studying role defined kinase–substrate interaction is that form complex signaling networks most often phosphorylate multiple substrates involved various cellular processes. In recent years, several new approaches have been developed to control activity given kinase. However, them fail regulate single target, likely...

10.1083/jcb.202106179 article EN cc-by The Journal of Cell Biology 2022-09-14

Abstract Reversible protein phosphorylation by kinases in extensively used to control a plethora of processes essential for proper development and homeostasis multicellular organisms. One main obstacle studying the role defined kinase-substrate interaction is that form complex signaling networks most often phosphorylate multiple substrates involved various cellular processes. In recent years, several new approaches have been developed activity given kinase. However, them fail regulate single...

10.1101/2021.03.26.433940 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2021-03-27
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