A5101469458- Synthesis of Organic Compounds
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Enzyme function and inhibition
- Ferroptosis and cancer prognosis
- Synthesis and biological activity
Shandong First Medical University
2021
Southwest Medical University
2021
Shandong Tumor Hospital
2021
Alnustone, a diarylheptane compound, exhibits potent growth inhibition against hepatocellular carcinoma (HCC) BEL-7402 cells. However, the underlying mechanisms associated with its anticancer activity remain unknown. In present study, we evaluated effect of alnustone several human cancers focused on HCC and possible mechanisms. The results showed that significantly inhibited cancer cells by CCK-8 assay. Alnustone markedly induced apoptosis decreased mitochondrial membrane potential in HepG2...
e20519 Background: Immune checkpoint inhibitors have revolutionized the patterns of tumor treatment with significantly improved survival. However, it’s worth noting that objective response rate PD-1/PD-L1 monotherapy is just 20% in non-small cell lung cancer (NSCLC) patients, and biomarkers for prognosis patients receiving are urgently needed. LILRB2 (ILT4) known as an immunosuppressive molecule promotes development progression NSCLC. relationship between expression immune microenvironment...