A5043679357- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Wnt/β-catenin signaling in development and cancer
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Genetics and Neurodevelopmental Disorders
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Neuroscience and Neural Engineering
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Antimicrobial Peptides and Activities
- Photoreceptor and optogenetics research
- Helicobacter pylori-related gastroenterology studies
- Chemical Synthesis and Analysis
- Cancer-related gene regulation
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Galectins and Cancer Biology
- Knee injuries and reconstruction techniques
- Circular RNAs in diseases
- Pharmacological Receptor Mechanisms and Effects
- Neural dynamics and brain function
University of Isfahan
2014-2024
Morehouse School of Medicine
2024
University Kebangsaan Malaysia Medical Centre
2014-2022
National University of Malaysia
2014-2018
Aptamers developed using in vitro Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technology are single-stranded nucleic acids 10–100 nucleotides length. Their targets, often with specificity and high affinity, range from ions small molecules to proteins other biological as well larger systems, including cells, tissues, animals. rival conventional antibodies improved performance, due aptamers’ unique biophysical biochemical properties, size, synthetic accessibility, facile...
Abstract Long non-coding RNAs (lncRNAs) are biomarkers for diagnosis and treatment of Parkinson’s disease (PD). Since dopaminergic cell transplantation is a clinical method to treat PD, this study investigated the effects therapy on expression some lncRNAs genes related PD. In study, Twenty-eight rats were randomly assigned four experimental groups. The control group (Sal group) received saline injections. Par was PD rat model with 6-hydroxydopamine (6-OHDA) injection in right striatum (ST)....
There is increasing evidence pointing toward the role of inflammatory processes in epileptic seizures, and reciprocally, prolonged seizures induce more inflammation brain. In this regard, effective strategies to control epilepsy resulting from neuroinflammation could be targeted. Based on available data, preconditioning (PC) with low dose lipopolysaccharide (LPS) through regulation TLR4 signaling pathway provides neuroprotection against subsequent challenge injury To test this, we examined...
Abstract N-methyl-D-aspartate receptors (NMDAR) play a central role in epileptogensis and NMDAR antagonists have been shown to antiepileptic effects animals humans. Despite significant progress the development of therapies over previous 3 decades, need still exists for novel therapies. We screened an in-house library small molecules targeting NMDA receptor. A indolyl compound, 2-(1,1-Dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde, (DDBM) showed best binding with receptor...
The production of short anticancer peptides in recombinant form is an alternative method for costly chemical manufacturing. However, the limitations host toxicity, bioactivity and column purification have impaired mass quantities. In this study, cationic were produced aggregated inclusion bodies by double fusion with a central protein that has anti-cancer activity. Tachiplicin I (TACH) Latarcin 1 (LATA) fused N- C-terminus MAP30 protein, respectively. We successfully TACH-MAP30-LATA alone E....
To identify and study the epidemiology of Leishmania species isolated from patients with leishmaniasis by PCR method in Sabzevar, Khorasan Razavi Province, Iran. Aspirated samples lesions 86 confirmed used for direct smear preparation. The are prepared cultured Novy-MacNeal-Nicolle Roswell Park Memorial Institute-1640 culture mediums. After extraction DNA using phenol-chloroform, parasite kintoplast gene amplification was done PCR. electrophoresis pattern each compared standard tropica (L....
Event Abstract Back to Effects of lipopolysaccharide preconditioning on pentylenetetrazol-induced seizure in rat model epilepsy Elham Amini1*, Mojtaba Golpich1, Zahurin Mohamed2, Raymond Azman Ali1, Abolhassan Ahmadiani3 and Norlinah Mohamed Ibrahim1 1 UKM Medical Centre (HUKM), Department Medicine, Faculty Medicine , Malaysia 2 University Malaya, Pharmacology, 3 Shahid Beheshti Sciences, Neuroscience Research Center, Iran Epilepsy is considered as one the oldest neurological conditions...
Parkinson’s disease (PD) is a chronic neurodegenerative movement disorder characterized by the progressive and massive loss of dopaminergic neurons neuronal apoptosis in substantia nigra pars compacta depletion dopamine striatum, which lead to pathological clinical abnormalities. A numerous cellular processes including oxidative stress, mitochondrial dysfunction, accumulation α-synuclein aggregates are considered contribute pathogenesis disease. further understanding molecular mechanisms...