A5012951447- Cell death mechanisms and regulation
- Retinal Development and Disorders
- PARP inhibition in cancer therapy
- Retinal Diseases and Treatments
- Dialysis and Renal Disease Management
- interferon and immune responses
- DNA Repair Mechanisms
- Coenzyme Q10 studies and effects
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Autophagy in Disease and Therapy
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Chronic Kidney Disease and Diabetes
- Genetic Associations and Epidemiology
- Erythropoietin and Anemia Treatment
- Phytochemistry and Biological Activities
- Mitochondrial Function and Pathology
- Intraocular Surgery and Lenses
Ludwig-Maximilians-Universität München
2011-2020
Friedrich-Alexander-Universität Erlangen-Nürnberg
2014
Age-related macular degeneration (AMD) is one of the leading causes blindness. Degeneration retinal pigment epithelium (RPE) pathognomonic for disease, and oxidative stress plays an important role in pathogenesis this disease. This study investigates potential antiapoptotic cytoprotective effects idebenone on cultured RPE cells (ARPE-19) under conditions stress.ARPE-19 were treated with 1-100 µ<smlcap>M</smlcap> idebenone. Cell viability (MTT assay), induction intracellular reactive oxygen...
Significant association signals from genome-wide studies (GWAS) point to genomic regions of interest. However, for most loci the causative genetic variant remains undefined. Determining expression quantitative trait (eQTL) in a disease relevant tissue is an excellent approach zoom on disease- or trait-associated and hitherto mechanisms. To this end, we explored regulation gene healthy retina (n = 311) generated largest cis-eQTL data set available date. Genotype- RNA-Seq underwent rigorous...
Age-related macular degeneration (AMD) is the leading cause of blindness among white caucasians over age 50 years with a prevalence rate expected to increase markedly an anticipated in life span world population. To further expand our knowledge genetic architecture disease, we pursued candidate gene approach assessing 25 genes and total 109 variants. Of these, synonymous single nucleotide polymorphism (SNP) rs17810398 located death-associated protein-like 1 (DAPL1) was found be associated...
Purpose: Oxidative stress plays an important role in the pathogenesis of several neurodegenerative diseases including glaucoma. Astrocytes are supposed to play a glaucoma pathogenesis. This study investigates antiapoptotic and cytoprotective effects idebenone on optic nerve head astrocytes (ONHA) under oxidative stress. Methods: ONHA were treated with 1 150 µM idebenone. Cell viability (MTT assay live-dead assay), induction intracellular reactive oxygen species, senescence-associated...
To evaluate optical-coherence-tomography (OCT)-morphological and clinical parameters three years after primary rhegmatogenous retinal detachment (RRD) repair surgery the role of postoperative foveal bulge sign.
Background Cardiovascular morbidity and mortality is very important in patients with chronic renal failure. This occurs even mild impairment of function may be related to oxidative stress inflammation. The nephrectomized apo E knockout mouse an accepted model for evaluating atherosclerosis dysfunction. Erythropoietin derivates showed anti-oxidative anti-inflammatory effects. Therefore, this study evaluates the effects Darbepoetin on markers inflammation atherosclerotic lesions mice Methods...
Purpose: To evaluate the effects of current hygiene standards for enucleation postmortem eyes by investigating number microorganisms during subsequent steps decontamination and tissue processing.Materials methods: This prospective, non-randomized cohort study includes 184 92 human donors. Enucleation was performed, according to an ophthalmic surgical procedure. Two groups were generated as follows: right allocated group A, left B. In a mucosal disinfectant used accessorily. Conjunctival...
Abstract Purpose Age related macular degeneration is one of the leading causes blindness. Oxidative stress plays an important role in pathogenesis this disease. This study investigates possible anti‐apoptotic and cytoprotective effects idebenone on retinal pigmentepithelial cells (ARPE19) under oxidative stress. Methods ARPE19 were treated with 1 to 100 µM idebenone. Cell viability (tetrazolium dye‐reduction assay live‐dead assay) expression BAX Bcl‐2, two key modulators apoptosis, their...