A5038050777- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Organ Transplantation Techniques and Outcomes
- Aortic Disease and Treatment Approaches
- Liver physiology and pathology
- Infective Endocarditis Diagnosis and Management
- Congenital heart defects research
- Cardiovascular Issues in Pregnancy
- Cardiomyopathy and Myosin Studies
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Viral Infections and Immunology Research
- Tissue Engineering and Regenerative Medicine
- Coronary Artery Anomalies
- Electrospun Nanofibers in Biomedical Applications
- Myasthenia Gravis and Thymoma
- Transplantation: Methods and Outcomes
- Pancreatic function and diabetes
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Function and Risk Factors
- Vascular anomalies and interventions
UC Davis Children's Hospital
2024
The University of Texas Southwestern Medical Center
2017-2022
Children's Medical Center
2017-2021
Southwestern Medical Center
2018
Lucile Packard Children's Hospital
2012
Stanford University
2010
California University of Pennsylvania
2005-2006
University of Pennsylvania
2002-2004
RELX Group (Netherlands)
2004
Hy-Line (United States)
2004
Cellular therapy for myocardial injury has improved ventricular function in both animal and clinical studies, though the mechanism of benefit is unclear. This study was undertaken to examine effects cellular injection after infarction on elasticity. Coronary artery ligation Lewis rats followed by direct human mesenchymal stem cells (MSCs) into acutely ischemic myocardium. Two weeks postinfarct, elasticity mapped atomic force microscopy. MSC-injected hearts near infarct region were twofold...
Apelin has been shown ex vivo to be a potent cardiac inotrope. This study was undertaken evaluate the in effects of apelin on function native and ischemic cardiomyopathic rat hearts using novel combination perivascular flow probe conductance catheter.Native rats (n =32) heart failure 6 weeks after left anterior descending coronary artery ligation =22) underwent median sternotomy with placement around ascending aorta pressure volume catheter into ventricle. Compared sham-operated rats,...
Background— Despite advances in surgical and percutaneous coronary revascularization, ongoing ischemia that is not amenable to standard revascularization techniques a major cause of morbidity mortality. Hepatocyte Growth Factor (HGF) has potent angiogenic anti-apoptotic activities, this study evaluated the functional biochemical effects HGF gene transfer rat model postinfarction heart failure. Methods Results— Lewis rats underwent ligation left anterior descending artery with direct...
Apoptosis secondary to acute ischemia and chronic remodeling is implicated as a mediator of heart failure. This study was designed assess the effect in vivo viral gene transfer anti-apoptotic factor Bcl-2 block apoptosis preserve ventricular geometry function.In rabbit model regional followed by reperfusion, an experimental group treated with adeno-Bcl-2 compared control receiving empty vector adeno-null. Function assessed echocardiography, sonomicrometry border zone normal left ventricle...
Heart failure following myocardial infarction (MI) is a significant cause of morbidity and mortality remains difficult therapeutic challenge. Hepatocyte growth factor (HGF) potent angiogenic anti-apoptotic protein whose receptor upregulated MI. This study was designed to investigate the ability HGF prevent heart in rat model experimental MI.The rats underwent direct intramyocardial injection with replication-deficient adenovirus encoding (n = 7) or null virus as control 3 weeks ligation left...
Mesothelial inclusion cysts are rare and even more when encountered in around the pericardium. This case report highlights postoperative management of a patient with this disease, combination development chylothorax after mitral valve surgery undefined relationship between two disease processes setting cardiofaciocutaneous syndrome.
Enhanced activity of matrix metalloproteinases (MMPs) has been associated with extracellular degradation and ischemic heart failure in animal models human patients. This study evaluated the effects MMP inhibition by gene transfer TIMP-1 a rat model cardiomyopathy.Rats underwent ligation left anterior descending coronary artery direct intramyocardial injection replication-deficient adenovirus encoding (n=8) or null virus as control vector (n=8), animals were analyzed after 6 weeks. Both...
Abstract Significant inter‐ and intra‐center practice variability is present in pediatric donor heart acceptability. This may contribute to variation the refusal rate impact waitlist time, morbidity, mortality, transplant rates. In order reduce variability, our center developed implemented a comprehensive strategy regarding acceptance September 2017. The aim of this study was assess on time outcomes as well early post‐transplant outcomes. We performed single‐center, retrospective analysis...
Impacted pediatric tracheobronchial thrombus is an uncommon diagnosis. There are no clearly proven therapeutic options for airway casts due to a similar process, plastic bronchitis. Cryotherapy, specifically cryoextraction, has shown potential as option in adults with and cast. We describe the novel application of this method complex patient.
22q11.2 deletion syndrome (22q11.2DS) is the most common human chromosomal microdeletion, causing developmentally linked congenital malformations, thymic hypoplasia, hypoparathyroidism, and/or cardiac defects. Thymic hypoplasia leads to T cell lymphopenia, which often results in mild SCID. Despite decades of research, molecular underpinnings leading 22q11.2DS remain unknown. Comparison embryonic thymuses from mouse models (Tbx1neo2/neo2) revealed proportions mesenchymal, epithelial, and...
•IVSH is a rare complication after cardiac procedures.•It results from myocardial infarction, coronary intervention, and/or direct trauma.•It associated with morbidity, mortality, and extracorporeal membrane oxygenation support.•Echocardiography aids in diagnosis follow-up of IVSH.•Spontaneous fistula between the septal hematoma RV led to decompression recovery.
Injury to vital structures posterior the sternum is a complication associated with redo sternotomy in congenital cardiac surgery. The goal of our study was novel evaluation real-time cine cardiovascular magnetic resonance (CMR) predict presence significant retrosternal adhesions and vascular prior patients heart disease.
Paraganglioma is a rare extra-adrenal tumor of the paraganglia often found in association with sympathetic and parasympathetic nerves. The case presented 10-year-old boy hemoptysis who was to have an obstructive bronchial mass. He underwent surgical resection biopsy confirmed primary pulmonary paraganglioma. subsequently associated genetic syndrome. This first report describing paraganglioma child.