About
Contact & Profiles
A5091591681
Research Areas
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Ion channel regulation and function
Central South University
2020
Xiangya Hospital Central South University
2020
The causative link between focal cortical malformations (FCMs) and epilepsy is well accepted, especially among patients with dysplasia type II (FCDII) tuberous sclerosis complex (TSC). However, the mechanisms underlying seizures remain unclear. Using a mouse model of TSC- FCDII-associated FCM, we showed that FCM neurons were responsible for seizure activity via their unexpected abnormal expression hyperpolarization-activated cyclic nucleotide-gated potassium channel isoform 4 (HCN4), which...
10.1126/scitranslmed.abc1492
article
EN
Science Translational Medicine
2020-11-18
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