A5020352950- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Growth Hormone and Insulin-like Growth Factors
- Bone fractures and treatments
- Nutrition and Health in Aging
- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Vitamin D Research Studies
- Diet and metabolism studies
- Parathyroid Disorders and Treatments
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
- Muscle metabolism and nutrition
- Nutritional Studies and Diet
- Estrogen and related hormone effects
- Bone and Dental Protein Studies
- Bone and Joint Diseases
- Periodontal Regeneration and Treatments
- Orthodontics and Dentofacial Orthopedics
- Dental materials and restorations
- Temporomandibular Joint Disorders
- Medical Imaging and Pathology Studies
- Healthcare Systems and Practices
University Hospital of Geneva
2012-2022
University of Geneva
1997-2015
Geneva College
2005-2014
Hôpital Beau-Séjour
2014
World Health Organization
1994-2011
Hôpital Nestlé
2001-2008
World Health Organization - Pakistan
2000
University of Arizona
1999
Global Social Observatory
1999
Weatherford College
1997
Wnt/beta-catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast differentiation and mineralized matrix formation. We show that Dkk1, unlike Dkk2, negatively regulates formation.The co-receptor LRP5 critical regulator of mass. Dickkopf (Dkk) proteins act as natural antagonists by bridging LRP5/6 Kremen, inducing internalization complex. are thus expected regulation However, deficiency results...
To evaluate the role of tumor necrosis factor (TNF alpha) in bone loss resulting from estrogen deficiency, effects ovariectomy were explored six-month-old transgenic mice expressing high blood levels a soluble TNF receptor type I (sTNFR1)-FcIgG3 fusion protein, which neutralizes alpha, and their nontransgenic littermates used as controls. These identical to control mass (evaluated by mineral density content) strength. 12 weeks after ovariectomy, decrease increase osteocalcin (marker...
Strontium ranelate given to intact rats at doses up 900 mg/kg/day increases bone resistance, cortical and trabecular volume, micro-architecture, mass, total ALP activity, thus indicating a bone-forming activity an improvement of overall tissue quality.Various anti-osteoporotic agents are available for clinical use; however, there is still need drugs able positively influence the coupling between formation resorption increase mass strength. (PROTELOS), new chemical entity containing stable...
Abstract In the design of new strategies for treatment osteoporosis, noninvasive, precise, and sensitive bone mass measurement capable detecting changes over short periods time in small animals is essential. Most models described thus far require sacrifice and/or display low reproducibility. Using a dual-energy x-ray absorptiometer (DEXA; Hologic QDR-1000) an ultrahigh-resolution mode, we measured mineral density (BMD) rats at levels lumbar spine (L1–4), proximal tail (caudal vertebrae...
Beside its influence on determinants of bone strength (geometry, microarchitecture), which is likely to be related a cellular effect, strontium ranelate improves tissue quality as evaluated by nanoindentation, increasing elastic modulus, hardness, and dissipated energy in vertebrae rats treated for 104 wk with daily dose from 0 900 mg/kg.We previously showed that treatment the mechanical properties vertebral body long midshaft intact rats. The increased failure obtained essentially caused an...
Objectives: The aims were to investigate whether the use of platelet-rich fibrin membranes (PRF) for socket filling could improve microarchitecture and intrinsic bone tissue quality alveolar after premolar extraction assess influence surgical procedure before implant placement. Material Methods: Twenty-three patients requiring followed by placement randomized three groups: (1) simple with PRF, (2) mucosal flap (3) controls without filling. Implant was performed at week 8, a biopsy obtained...
Abstract The weightless environment during spaceflight induces site-specific bone loss. 30-day Bion-M1 mission offered a unique opportunity to characterize the skeletal changes after and an 8-day recovery period in mature male C57/BL6 mice. In femur metaphysis, decreased trabecular volume (−64% vs. Habitat Control), dramatically increased resorption (+140% Control) induced marrow adiposity invasion. At diaphysis, cortical thinning associated with periosteal was observed. Flight animal group,...
Bone development is a multistep process that includes patterning of skeletal elements, commitment hematopoietic and/or mesenchymental cells to chondrogenic and osteogenic lineages, further differentiation into three specialized cell types: chondrocytes in cartilage osteoblasts osteoclasts bone. Although PRL has multitude biological actions addition its role the mammary gland, very little known about effect on Mice carrying germline null mutation for receptor gene have been produced our...
Abstract Protein undernutrition is a known factor in the pathogenesis of osteoporotic fracture elderly, but mechanisms bone loss resulting from this deficiency are still poorly understood. We investigated effects four isocaloric diets with varying levels protein content (15, 7.5, 5, and 2.5% casein) on areal mineral density (BMD), ultimate strength, histomorphometry, biochemical markers remodeling, plasma IGF-I, sex hormone status adult female rats. After 16 weeks casein diet, BMD was...
Abstract Mandibular and systemic bone loss are poorly associated. We compared the effect of isocaloric protein undernutrition and/or ovariectomy on BMD microstructure mandibular alveolar proximal tibia sites in adult rats. was significantly less affected. Introduction: Whether axial or peripheral skeleton respond similarly to remains a subject controversy. have previously shown that mechanical loading during mastication influences mass architecture bone. Isocaloric known cause deterioration...
Dietary protein deficiency, common in elderly, is associated with decreased areal bone mineral density and plasma insulin-like growth factor I (IGF-I). To investigate the early adaptation of cells to restriction, 6-month-old female rats were pair-fed isocaloric 15% (control) or 2.5% casein diets for 14 days. Animals then treated daily rhIGF-I/IGFBP-3 (1:4, 2.5 mg IGF-I/kg BW) vehicle 10 After double-labeling, proximal metaphysis mid-diaphysis tibia analyzed histomorphometrically. Plasma...
Abstract Low dietary intake is common in elderly males with low femoral neck areal bone mineral density (BMD). To evaluate the selective influence of a low-protein diet pathogenesis osteoporosis and to uncover early late adaptation cells protein deficiency, 8-month-old male rats were pair-fed control (15% casein) or isocaloric (2.5% for 1 7 months. BMD, ultimate strength, stiffness, absorbed energy measured tibia proximal metaphysis diaphysis. After double-labeling, histomorphometric...