A5000303136- Multiple Sclerosis Research Studies
- Genetic Associations and Epidemiology
- Peripheral Neuropathies and Disorders
- Cancer-related molecular mechanisms research
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Leadership, Courage, and Heroism Studies
- Systemic Lupus Erythematosus Research
- COVID-19 and Mental Health
- Empathy and Medical Education
- Pregnancy and preeclampsia studies
- Bariatric Surgery and Outcomes
- Gestational Diabetes Research and Management
- Acute Lymphoblastic Leukemia research
- Heme Oxygenase-1 and Carbon Monoxide
- Mindfulness and Compassion Interventions
- Diversity and Career in Medicine
- Innovations in Medical Education
- Phytochemical Studies and Bioactivities
- Resilience and Mental Health
- Clinical Reasoning and Diagnostic Skills
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Psychological Well-being and Life Satisfaction
Queen Mary University of London
2021-2024
Barts Health NHS Trust
2024
Royal London Hospital
2024
University of Cambridge
2018-2023
Whipps Cross University Hospital
2020
Auckland University of Technology
2014
Abstract Aim Excessive gestational weight gain increases risk of diabetes mellitus ( GDM ) but it remains unclear whether control after diagnosis improves outcomes. We assessed whether: (1) total during pregnancy (0–36 weeks); (2) early (0–28 weeks, before diagnosis); or (3) late (28–36 diagnosis) are associated with maternal–fetal Methods Some 546 women who delivered viable singleton infants at a single UK obstetric centre (October 2014 to March 2017) were included in this retrospective...
Higher body mass index (BMI) during early life is thought to be a causal risk factor for multiple sclerosis (MS). We used longitudinal Mendelian randomisation (MR) determine whether there critical window which BMI influences MS risk.
Background Aquaporin-4 (AQP4) antibody associated neuromyelitis optica (NMOSD) requires long-term immunosuppression. Rituximab is increasingly used worldwide, however the optimal regime not established. Methods We retrospectively examined different rituximab regimens in AQP4-NMOSD. Standard monotherapy (SM; 6 monthly infusions), SM plus oral steroids (SM+S), extended interval dosing (EID; guided by CD19 repopulation) and EID with (EID+S) were compared. The primary outcome was time to first...
Nitrous oxide (N2O), often known as "laughing gas," ranks a widely used recreational drug among young people in the UK, with 3.9 % of adults aged 16–24 reporting its use 2021–2022. Besides neurological risks, there is emerging evidence linking N2O misuse to serious haematological issues, including arterial and venous thrombosis. The project aimed elucidate prevalence usage (18–35 years) unprovoked thromboembolism (VTE) between January 2021 July 2023. Patient records from three East London...
Abstract Objective Higher Body Mass Index (BMI) during early life is thought to be a causal risk factor for Multiple Sclerosis (MS). We used longitudinal mendelian randomisation (MR) determine whether there critical window which BMI influences MS risk. Methods Summary statistics childhood and susceptibility were obtained from recent large GWAS. generated exposure instruments four non-overlapping epochs (< 3 months, months-1.5 years, 2-5 7-8 years) performed MR using the inverse-variance...
<b>Introduction:</b> NICE UK guidelines state that we should measure spirometry on all patients admitted with an exacerbation of COPD prior to discharge. The 2017/18 national audit showed only 40.5% had a result recorded. <b>Aims and Objectives:</b> aim this study was establish our current practice at Whipps Cross Hospital, London, as well what measures could be introduced improve this. <b>Methods:</b> We reviewed the notes in January 2020 recorded whether available admission and/or...
Background Aquaporin-4 (AQP4) antibody associated neuromyelitis optica spectrum disorder (NMOSD) requires long-term immunomodulation. In refractory cases rituximab can be used, however the optimal regime is not established. Methods We retrospectively examined different regimes in AQP4-NMOSD. Standard mono- therapy (SM; 6 monthly infusions), SM plus oral steroids (SM+S), extended interval dosing (EID; with retreat- ment at CD19 >1%) and EID (EID+S) were compared. The primary outcome was...