A5032154233- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS oral health manifestations
- Immune Cell Function and Interaction
- HIV, Drug Use, Sexual Risk
- Diverse Scientific Research Studies
- Blood groups and transfusion
- HIV/AIDS Impact and Responses
- Diverse Approaches in Healthcare and Education Studies
- Adolescent Sexual and Reproductive Health
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Advanced Biosensing Techniques and Applications
- Energy and Environment Impacts
- Pneumonia and Respiratory Infections
- Pregnancy and preeclampsia studies
- Mycobacterium research and diagnosis
- Pregnancy and Medication Impact
- Pharmacological Effects and Toxicity Studies
- Molecular Biology Techniques and Applications
- Malaria Research and Control
Dire Dawa University
2025
Ethiopian Public Health Institute
2001-2019
Objective: To study the association between clinical axis of World Health Organization (WHO) staging system HIV infection and disease laboratory markers in HIV-infected Ethiopians. Design: Cross-sectional study. Methods: Clinical manifestations stage HIV-positive individuals participating a cohort progression, patients hospitalized with suspicion AIDS, were compared to CD4+ T-cell count viral load. Results: Of 86 participants study, 53 (62%), 16 (19%), one (1.2%) 1, 2, 3 4, respectively....
We investigated the development and maintenance of proliferative antibody responses to apical membrane antigen-1 (AMA-1) epitopes in a holoendemic area western Kenya. Young children (< 10 years), older (10-17 adults (> or = 18 years) were followed longitudinally for T-cell at 3 time points with an interval 3-4 months. The against AMA-1 T (PL171, PL172, PL173, PL186, PL191, PL192) not stable during follow-up; however, response mycobacterial antigen PPD was highly stable. responder...
Background: Adequate gestational weight gain affects birth outcomes and increases the risk of non-communicable diseases later in life. Weight pregnant Ethiopian women with hyperemesis gravidarum has not been investigated comprehensively. Objective: To assess determinants gravida Dire Dawa Administration, Eastern Ethiopia. Design: Unmatched case-control study Methods: Pregnant who visited health facilities for ante-natal care were recruited into this using random sampling techniques. The...
Background: Treatment failure (TF) among patients receiving antiretroviral therapy (ART) against human immunodeficiency virus (HIV) impacts on treatment outcome and is becoming a public health concern globally. However, magnitude of TF factors leading to it are poorly defined in the context Ethiopia. Thus, aim this study was determine assess its determinants HIV-infected ART Methods: A prospective retrospective conducted from March 2016 2017. Retrospective clinical laboratory data were...
The present study monitored the changes in human immunodeficiency virus (HIV) viral load using a reverse transcriptase (RT) assay and an HIV-1 RNA based assay, relates these data to dynamics of CD4 cell counts. samples examined originate from prospective subtype C infected, untreated Ethiopians followed twice yearly over period up 5 years. ExaVir Load test, version 1, was used for isolation quantitation RT plasma. activities recovered were compared copy numbers, which had been determined...
Early diagnosis of infants infected with HIV (EID) and early initiation treatment significantly reduces the rate disease progression mortality. One challenges to identification HIV-1-infected is availability and/or access quality molecular laboratory facilities which perform virologic assays suitable for accurate status infants.We conducted a joint site assessment designed laboratories expansion DNA polymerase chain reaction (PCR) testing based on dried blood spot (DBS) EID in six regions...
Abstract Background Although treatment failure (TF) among population on antiretroviral therapy (ART) become a major public health threat, its magnitude of and factors leading to it are poorly defined. Hence, we aimed estimate the TF determinants in Ethiopia. Methods A follow-up study was conducted from March 2016 2017. Clinical laboratory data were captured paticipants’ medical record. Socio-demographics explanatory variables collected using structured questionnaire. Participants with...
408 non-selected samples were obtained from healthy, adult individuals donating blood at the Ethiopian Red Cross Society-National Blood Transfusion Service. All screened for HIV using Vironostika Ag/Ab test, Amplicor DNA PCR and examined presence of reverse transcriptase (RT) ExaVir Load test (version 2). A panel supplementary tests was used to evaluate status discordant confirm positivity. One aim assess an RT based screening in comparison with other more conventional tests. An...
Background: Tuberculosis is one of the leading causes mortality and morbidity worldwide. Polymorphisms in TLR-2 gene have a diverse influence on innate immune response may result susceptibility active pulmonary tuberculosis diseases among particular families, ethnicities, races. However, genetic variation TLR2 to PTB our population has not been previously investigated. Thus, this study assesses association polymorphisms with Northwest Ethiopian population.
We studied HIV-1 clade C Gag-specific T-cell responses in five HIV-infected Ethiopians with a relatively slow (< 15 cells/μl per year) and fast (> 45 CD4 decline longitudinally. Six study subjects had directed to one or more Gag peptides. The persistence of strong broad anti-Gag cytotoxic T-lymphocyte was associated rate human leukocyte antigen alleles from the B27 supertype.
Purpose: Genetic diversities in different countries affect the performance of HIV test kits. Therefore, WHO recommends evaluation every kit countries’ context before its use. this study aimed to evaluate Genscreen ULTRA Ag–Ab and Bioelisa. Materials methods: The had used 400 characterized plasma samples obtained from CDC Atlanta bio-bank derived Africa, USA, Thailand. Results: Diagnostic both kits under was assessed at 95% CI. sensitivity negative predictive value 99.5% [95% CI, 97.2–99.9]...