Abstract Background This study aims to develop a diagnostic model help physicians determine whether thyroid nodules categorized as atypia of undetermined significance (AUS) in category III the Bethesda system are benign or malignant preoperatively. To create for predicting nodules' with AUS cytology based on clinical, ultrasonographic, and cytopathological findings. Methods is retrospective cohort involving patients (>19) at risk cancer who had thyroidectomy after an cytology. The dataset...

High-grade serous carcinoma is categorized based on p53 mutation status. A relationship known to exist between mutations and immunoexpression patterns, including overexpression, complete absence, cytoplasmic, wild-type patterns. The ubiquitin ligases WWP1 PARC, regulate activation, are hypothesized influence the pathogenesis of ovarian tumors. This retrospective study examined 7 low-grade carcinomas, 38 high-grade 15 cystadenomas, with immunohistochemical analyses performed for WWP1, p53....

In the etiopathogenesis of vitiligo, role suppressor cytokines, such as transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), associated with regulatory T-cells (Treg) is not completely known. this study, Treg-cell functions in skin patients nonsegmental vitiligo was investigated. Lesional nonlesional samples from 30 adult volunteers ranging age 18 to 36 years were compared normal area excision specimens benign melanocytic nevus cases controls. All evaluated staining for forkhead...

Aquagenic palmar wrinkling (APW) is an uncommon dermatological condition, which manifests as asymptomatic or tender papules and may cause discomfort manual functional limitations during its flares. Despite some studies implying a relationship between cystic fibrosis (CF) APW, there are also reports of APW cases without accompanying CF. In this report we describe 19-year-old ankylosing spondylitis patient, who developed lesions after the start combined salazopyrin indomethacin treatment. His...

AIM:To evaluate the interobserver variability in determining number of mitoses 10 high-power field (HPF) and thus tumor grade, to investigate how reduce grade discordance between observers most useful method identify patients who would receive an additional treatment. MATERIAL METHODS:Two hundred seventy cases with meningioma were re-evaluated by three experienced pathologists five senior residents.They determined mitotic figures HPF each slide.Re-evaluation cases, which found different...

Hypoxia is an important microenvironmental factor significantly affecting tumor proliferation and progression. The importance of hypoxia is, however, not well known in oncogenesis malignant melanoma.To evaluate the difference hypoxic gene expression signatures primary melanoma cell lines metastatic to find changes hypoxia-related genes at experimental conditions.Cell study.The mRNA levels conditions were evaluated by using real-time polymerase chain reaction. Depending on data, we focused...

Nuclei detection is a critical step in cytopathology for pleural cancer diagnosis. Because nuclei provide quantitative information about malignancy of cancer. It known that Convolutional Neural Networks (CNNs) considerable performance on object detection. We proposed convolutional detector, YOLOv3, to detect effusion (PE) images. The experiments were conducted 80 PE images containing 11157 nuclei. method achieved precision %94.10, recall %98.98, and F-measure %96.48. most important...

Serous effusions are common in clinical practice and they frequently encountered specimen type cytopathological assessment. Since this assessment is subjective, time-consuming cause intra- inter-observer variability, the need for an automated system arised. Identification of cancer cells serous effusion cytology allows early diagnosis also staging, prognosis monitoring these cells. The detection cell nuclei seen as corner stone diagnostic purposes automatic analysis images. Nuclei yield...

Serous effusion is frequently encountered specimen type in (cyto)pathological assessment. However, this assessment time-consuming and leads to variability among pathologists. The cell nuclei seen as the corner stone for diagnostic purposes automatic analysis of cytopathological images. In paper, a stacked sparse autoencoder (SSAE) proposed detection serous cytology. SSAE an unsupervised deep learning method which learns high-level features from just pixel intensities alone order identify...

The histopathological assessment of Oral Lichen Planus (OLP) and oral lichenoid lesions is relatively subjective. distinguishing criteria established by WHO effectively reproducible when all selection were fulfilling but sometimes fail to provide a reliable diagnosis. aim the present study was evaluate mast cell counts their distribution among OLP lesions. density localization cells examined in 22 patients with diagnosis (11 patients) or reactions c-kit/CD117 immunohistochemical toluidine...

The effects of L-theanine on hepatic microcirculation during ischemia-reperfusion injury have not yet been investigated. aim this study was to investigate the influence in rats.

The aim of this study is to investigate the methotrexate (MTX) in rat embryonal implantation and its association with Glycodelin A (GdA) Mucin-1 (MUC-1) expression. For purpose, 32 pregnant rats were divided into four equal groups: non-pregnant group I (n = 8, control) III 8) injected intraperitoneal single dose normal saline, II IV given 0.2 mg i.m. injection MTX before three months pregnancy. dams killed on 5th day gestation uterine horn samples removed. Following dissection routine...

Objective: Prostate cancer (PCa) patients suffer severe side effects of standard treatment beside the resistance to castration. PCa cells shows increased lipogenesis. Thymoquinone (TQ) inhibits cell proliferation, metastasis, and invasion. However, there was no study on effect TQ levels NEDDL4, PLA2G7, UCP2 lipid droplets (LD) related proteins. Hence, aims investigate impact UCP2, NEDD4L proteins DU145 PC3 lines.
 Materials Methods: Cells were cultured treated with a IC50 60 µM 80 for...

Light microscopic systems have the limited depth of field. The objects into focus only appear in-focus. When samples observed at microscope are thicker than focus, it is seen that some regions on images out and a whole completely in one single image can't be obtained. In this study, aimed to prevent problem produce an with optimal systems. literature, process was achieved extended using taken random along Z axis. proposed optimum focusing provided number series used obtained model. This...

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