A5053400500- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Trauma Management and Diagnosis
- Trauma and Emergency Care Studies
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Thermal Regulation in Medicine
- Restraint-Related Deaths
- Anesthesia and Sedative Agents
- Tracheal and airway disorders
- Disaster Response and Management
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Biomedical and Chemical Research
- Sepsis Diagnosis and Treatment
- Health and Medical Research Impacts
- Diversity and Career in Medicine
- Esophageal and GI Pathology
- Healthcare Technology and Patient Monitoring
- Hemophilia Treatment and Research
- Hemodynamic Monitoring and Therapy
- Abdominal Surgery and Complications
- Neonatal Respiratory Health Research
University Hospital Cologne
2015-2025
University of Cologne
2015-2023
Pan Am Clinic
2021-2023
Paracelsus Medical University
2023
LVR-Klinik Köln
2023
Kantonsspital St. Gallen
2022
Hospital of the Brothers of St. John of God
2022
Poliklinik für Endokrinologie, Diabetologie und Präventivmedizin
2014-2021
Orthopädische Praxis
2020
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2015
Objective Epinephrine is widely used for treatment of life-threatening hypotension, although new vasopressor drugs may merit evaluation. The purpose this study was to determine the effects vasopressin vs. epinephrine saline placebo on hemodynamic variables, regional blood flow, and short-term survival in an animal model uncontrolled hemorrhagic shock delayed fluid resuscitation. Design Prospective, randomized, laboratory investigation that a porcine measurement variables abdominal organ...
In Brief a porcine model of uncontrolled hemorrhagic shock, we evaluated the effects vasopressin versus an equal volume saline placebo fluid resuscitation on hemodynamic variables and short-term survival. Twenty-one anesthetized pigs were subjected to severe liver injury. When mean arterial blood pressure was <20 mm Hg heart rate decreased, randomly received either IV (0.4 U/kg; n = 7), (n or (1000 mL each lactated Ringer's solution hetastarch; 7). Thirty minutes after intervention,...
Summary Nitrous oxide continues to be used frequently and the possibility of inadvertent fatal hypoxaemia resulting from technical errors with its administration still exists. A Medline analysis revealed only a few case reports over last 30 years, closed claim reported ‘claims involving oxygen supply lines’ predating 1990. The aim this study was assess frequency nitrous oxide‐related catastrophes during general anaesthesia in Germany, Austria, Switzerland. As casualties are rare but...
During normothermic cardiac arrest, a combination of active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) with the inspiratory threshold valve (ITV) significantly improves vital organ blood flow, but this technique has not been studied during hypothermic arrest. Accordingly, we evaluated hemodynamic effects ACD + ITV CPR before, and after, administration vasopressin in porcine model Pigs were surface-cooled until their body core temperature was 26°C. After 10 min...
Background Patients in hemorrhagic shock often require emergent airway management. Clinical experience suggests that oxygen desaturation occurs rapidly these patients; however, data are scant. The hypothesis of this study was increasing levels shock, varying fraction inspired (Fio2) for preoxygenation, and fluid resuscitation significantly affect the duration until critical occurs. Methods Fifteen pigs were studied a model with controlled hemorrhage (15, 30, 45 ml/kg blood loss) randomized...
Contribution of the small intestine to systemic inflammation after cardiac arrest (CA) is poorly understood. The objective was evaluate whether an in vivo rat model 6 min CA suitable initiate intestinal ischaemia-reperfusion-injury and histomorphological changes inflammatory processes mucosa resp. sera. Adult male Wistar rats were subjected followed by cardio-pulmonary resuscitation. Proximal jejunum serum collected at h, 24 72 h 7 d post return spontaneous circulation (ROSC) from a control...
To investigate the effect of different ventilation settings on hemodynamic stability in severe controlled hemorrhagic shock.Prospective, randomized, animal study.Research laboratory a university hospital.Approximately 35-45 kg domestic pigs.Twenty-four pigs were bled 45 mL/kg (estimated 65% their calculated blood volume) and then ventilated with either 0 cm H2O positive end-expiratory pressure respiratory rate 14 ventilations/min (positive 14), or 5 pressure, 28 ventilations/min, tidal...
Peri-operative critical events are still a major problem in paediatric anaesthesia care. Access to more experienced healthcare teams might reduce the adverse event rate and improve outcomes.The current study analysed incidences of peri-operative cardiac arrest before after implementation specialised team training programme.Retrospective cohort with before-and-after analysis.Department Anaesthesiology Intensive Care Medicine, University Hospital Cologne, Germany.A total 36 243 anaesthetics (0...
Hypothermia is a severe, unpleasant side effect during general anesthesia. Thus, temperature surveillance prerequisite in anesthesia settings experimental surgeries. The gold standard to measure the core body (Tcore) placement of Swan-Ganz catheter pulmonary artery, which highly invasive procedure. Therefore, Tcore commonly examined urine bladder and rectum. However, these procedures are known for their inaccuracy delayed record temperatures. Zero-heat-flux (ZHF) thermometry an alternative,...
Abstract Background Endotracheal intubation continues to be the gold standard for securing airway in emergency situations. Difficult is still a dreadful situation when airway. Objective To compare VieScope with Glidescope and conventional Macintosh laryngoscopy (MAC) simulated difficult situation. Methods In this randomized controlled simulation trial, 35 anesthesiologists performed endotracheal using VieScope, GlideScope MAC order on certified manikin Results For primary endpoint of correct...
Abstract Background Failed airway management is the major contributor for anaesthesia-related morbidity and mortality. Cannot-intubate-cannot-ventilate scenarios are most critical emergency in management, belong to worst imaginable an anaesthetist’s life. In such situations, apnoeic oxygenation might be useful avoid hypoxaemia. Anaesthesia guidelines recommend careful preoxygenation application of high flow oxygen difficult intubation prevent episodes deoxygenation. this study, we evaluated...